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1.Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion, antigenicity, HBsAg and viral DNA

作者：Kuan-hui Xiang¹ ; ² ; Eleftherios Michailidis² ; Hai Ding¹ ; Ya-qin Peng¹ ; ³ ; Ming-ze Su¹ ; Yao Li¹ ; Xue-en Liu¹ ; Viet Loan Dao Thi² ; Xian-fang Wu² ; William M. Schneider² ; Charles M. Rice² ; Hui Zhuang¹ ; ^{zhuangbmu@126.com} ; Tong Li¹ ; ^{tongli08@vip.sina.com}

关键词：HBV ; HBsAg mutation ; Virion secretion ; Antigenicity ; &lsquo ; a&rsquo ; determinant ; Hepatitis B surface antigens ; Amino acid substitution ; DNA ; Viral ; Membrane proteins

刊名：Journal of Hepatology

出版年：2017

2.Oral administration of synthetic selenium nanoparticles induced robust Th1 cytokine pattern after HBs antigen vaccination in mouse model

作者：Mehdi Mahdavi^a ; ^b ; ^c ; Faranak Mavandadnejad^d ; Mohammad H. Yazdi^a ; ^e ; Elnaz Faghfuri^d ; Hura Hashemi^d ; Somayeh Homayouni-Oreh^d ; Ramin Farhoudi^f ; Ahmad R. Shahverdi^a ; ^d ; ^{shahverd@sina.tums.ac.ir}

关键词：HBV ; hepatitis B virus ; HBsAg ; hepatitis B surface antigen ; SeNPs ; selenium nanoparticles ; ELISA ; enzyme-linked immunosorbent assay ; PBS ; phosphate buffered saline ; CHB ; chronic hepatitis B ; LC ; liver cirrhosis ; HCC ; hepatocellular carcinoma ; HEPES ; 4-2-hydroxyethylpiperazine-1-2-ethanesulfonic acid ; FBS ; fetal bovine serum ; BrdU ; 10X 5-bromo-2&prime ; -deoxyuridine ; PBS-BSA ; phosphate buffered saline with bovine serum albumin ; PBMCs ; peripheral blood mononuclear cells ; PHA ; phytohaemagglutinin ; N

刊名：Journal of Infection and Public Health

出版年：2017

3.The role of quantitative hepatitis B surface antigen revisited

作者：Markus Cornberg¹ ; Vincent Wai-Sun Wong² ; Stephen Locarnini³ ; Maurizia Brunetto⁴ ; Harry L.A. Janssen⁵ ; Henry Lik-Yuen Chan² ; ^{hlychan@cuhk.edu.hk}

关键词：Hepatitis B ; HBsAg ; Pegylated interferon ; Entecavir ; Tenofovir ; Antiviral treatment

刊名：Journal of Hepatology

出版年：2017

4.Reduction of covalently closed circular DNA with long-term nucleos(t)ide analogue treatment in chronic hepatitis B

作者：Ching-Lung Lai¹ ; ² ; ^&dagger ; ; ^{hrmelcl@hku.hk} ; Danny Wong¹ ; ² ; ^&dagger ; ; ^{dannykhwong@gmail.com} ; Philip Ip³ ; Malgorzata Kopaniszen¹ ; Wai-Kay Seto¹ ; ² ; James Fung¹ ; ² ; Fung-Yu Huang¹ ; Brian Lee⁴ ; Giuseppe Cullaro⁵ ; Chun Kong Chong¹ ; Ringo Wu¹ ; Charles Cheng¹ ; John Yuen¹ ; Vincent Ngai¹ ; Man-Fung Yuen¹ ; ²

关键词：Hepatitis B virus ; Liver biopsy ; Antiviral therapy ; Virus replication ; Circular DNA

刊名：Journal of Hepatology

出版年：2017

5.Higher detection rates of amino acid substitutions in HBV reverse transcriptase/surface protein overlapping sequence is correlated with lower serum HBV DNA and HBsAg levels in HBeAg-positive chronic hepatitis B patients with subgenotype B2

作者：Mingze Su ; Kuanhui Xiang ; Yao Li ; Yutang Li ; Juan Deng ; Xizhan Xu ; Ling Yan ; Hui Zhuang ; ^{zhuangbmu@126.com" class="auth_mail" title="E-mail the corresponding author} ; Tong Li ; ^{tongli08@vip.sina.com" class="auth_mail" title="E-mail the corresponding author}

关键词：AA ; amino acid ; ADV ; adefovir dipivoxil ; CHB ; chronic hepatitis B ; HBeAg ; hepatitis B e antigen ; HBsAg ; hepatitis B surface antigen ; HBV ; hepatitis B virus ; HIV ; human immunodeficiency virus ; HSPGs ; highly sulfated heparan sulfate proteoglycans ; LdT ; telbivudine ; LMV ; lamivudine ; MHR ; major hydrophilic region ; NAs ; nucleos(t)ide analogs ; NAr ; nucleos(t)ide analog resistance ; RT ; reverse transcriptase ; S ; surface

刊名：Infection, Genetics and Evolution

出版年：2016

6.Clinical Significance of Quantitative HBsAg Titres and its Correlation With HBV DNA Levels in the Natural History of Hepatitis B Virus Infection

作者：Vijay K. Karra ; Soumya J. Chowdhury ; Rajesh Ruttala ; Sunil K. Polipalli ; Premashis Kar ; ^{premashishkar@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：HBeAg ; hepatitis B early antigen ; HBV ; hepatitis B virus ; IT ; immune tolerance phase ; IC ; immune clearance phase ; LR ; low-replicative phase

刊名：Journal of Clinical and Experimental Hepatology

出版年：2016

7.Effect of a polysaccharide from Poria cocos on humoral response in mice immunized by H1N1 influenza and HBsAg vaccines

关键词：AAALAC ; Accreditation of Laboratory Animal Care International ; APCs ; antigen presenting cells ; CE ; capillary electrophoresis ; DCs ; dendritic cells ; ELISA ; enzyme linked immunosorbent assays ; FBS ; fetal bovine serum ; HBsAg ; hepatitis B virus surface antigen ; HPGPC ; high performance gel permeation chromatography ; iNOS ; NO synthase ; MPL ; 3-O-desacyl-4&prime ; -monophosphoryl lipid A ; NF-κB ; activating nuclear factor κB ; NK ; natural killer ; NO ; nitric oxide ; OD ; optical density ; TFA ; trifluoroacetic a

刊名：International Journal of Biological Macromolecules

出版年：2016

8.In vivo reduction of hepatitis B virus antigenemia and viremia by antisense oligonucleotides

作者：Gaetan Billioud¹ ; Robert L. Kruse⁴ ; Melissa Carrillo¹ ; Christina Whitten-Bauer¹ ; Dacao Gao² ; Aneeza Kim² ; Leon Chen⁴ ; Michael L. McCaleb² ; Jeffrey R. Crosby² ; Robert Hamatake³ ; Zhi Hong³ ; Urtzi Garaigorta¹ ; Eric Swayze² ; ^{eswayze@ionisph.com" class="auth_mail" title="E-mail the corresponding author} ; Karl-Dimiter Bissig⁴ ; ^{bissig@bcm.edu" class="auth_mail" title="E-mail the corresponding author} ; Stefan Wieland¹ ; ^{swieland@scripps.edu" class="auth_mail" title="E-mail the corresponding author} ; ^{stefan.wieland@unibas.ch" class="auth_mail" title="E-mail the corresponding author}

关键词：HBV ; hepatitis B virus ; ASO ; antisense oligonucleotide ; HBsAg ; hepatitis B surface antigen ; HCC ; hepatocellular carcinoma ; NTCP ; sodium taurocholate cotransporting polypeptide ; cccDNA ; circular covalently closed DNA ; RT ; reverse transcriptase ; HBcAg ; hepatitis B core antigen ; NUC ; nucleos(t)ide analogue ; RNAi ; RNA interference ; MOE ; methoxy-ethyl ; HBeAg ; hepatitis B e antigen ; GAPDH ; Glyceraldehyde 3-phosphate dehydrogenase ; g.e. ; genome equivalent ; ISG ; interferon-stimulated gene ; ETV ; entecavi

刊名：Journal of Hepatology

出版年：2016

9.Treatment of chronic hepatitis D with the entry inhibitor myrcludex B: First results of a phase Ib/IIa study

作者：Pavel Bogomolov¹ ; ² ; Alexander Alexandrov³ ; Natalia Voronkova¹ ; ² ; Maria Macievich¹ ; ² ; Ksenia Kokina¹ ; ² ; Maria Petrachenkova¹ ; ² ; Thorsten Lehr⁴ ; Florian A. Lempp⁵ ; ⁶ ; Heiner Wedemeyer⁷ ; Mathias Haag⁸ ; ⁹ ; ¹⁰ ; Matthias Schwab⁸ ; ⁹ ; ¹⁰ ; ¹¹ ; ¹² ; Walter E. Haefeli⁵ ; ¹³ ; Antje Blank⁵ ; ¹³ ; ^&dagger ; ; ^{antje.blank@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Stephan Urban⁵ ; ⁶ ; ^&dagger ;

关键词：ALT ; alanine aminotransferase ; AST ; aspartate aminotransferase ; BSA ; bovine serum albumin ; blq ; below limit of quantification ; cccDNA ; covalently closed circular deoxyribonucleic acid ; CHB ; chronic hepatitis B ; CHD ; chronic hepatitis D ; d ; hepatocyte death rate ; DNA ; deoxyribonucleic acid ; HBeAg ; HBe antigen ; HBsAg ; HBs antigen ; HBV ; hepatitis B virus ; HDV ; hepatitis D virus ; IFN ; interferon ; lod ; limit of detection ; loq ; limit of quantification ; NOEL ; no observed effect level ; NLME ; non-linear

刊名：Journal of Hepatology

出版年：2016

10.The DNA damage repair protein Ku70 regulates tumor cell and hepatic carcinogenesis by interacting with FOXO4

作者：Tingting Zhang^a ; Xiubing Zhang^b ; Weidong Shi^b ; Jian Xu^b ; Hui Fan^b ; Shusen Zhang^a ; Runzhou Ni^a ;

关键词：Hepatocellular carcinoma ; Ku70 ; p27kip1 ; Cell proliferation ; FOXO4

刊名：Pathology - Research and Practice

出版年：2016

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