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1.Synergistic role of solid lipid and porous silica in improving the oral delivery of weakly basic poorly water soluble drugs

作者：Rokhsana Yasmin ; Shasha Rao ; Kristen Bremmell ; Clive Prestidge ; ^{Clive.Prestidge@unisa.edu.au}

关键词：Oral delivery ; Poorly water soluble drugs ; Solid lipid ; Porous silica ; Solubilization

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

2.Smart composite materials based on chitosan microspheres embedded in thermosensitive hydrogel for controlled delivery of drugs

作者：Marieta Constantin ; Sanda-Maria Bucatariu ; Florica Doroftei ; Gheorghe Fundueanu ; ^{ghefun@icmpp.ro}

关键词：Smart composite hydrogel ; Thermoresponsive polymer ; Chitosan ; Microsphere ; Drug release

刊名：Carbohydrate Polymers

出版年：2017

3.Insomnia From Drug Treatments: Evidence From Meta-analyses of Randomized Trials and Concordance With Prescribing Information

作者：Anthony G. Doufas ; MD ; PhD^a ; ^f ; Orestis A. Panagiotou ; MD ; PhD^g ; ^h ; Periklis Panousis ; MD^a ; Shane Shucheng Wong ; MD^b ; John P.A. Ioannidis ; MD ; DSc^c ; ^d ; ^e ; ⁱ ; ^{jioannid@stanford.edu}

关键词：AE ; adverse event ; CDSR ; Cochrane Database of Systematic Reviews ; COMTI ; catechol-O-methyltransferase inhibitor ; DOPA ; dopamine ; FDA ; Food and Drug Administration ; GABA ; γ-aminobutyric acid ; GnRH ; gonadotropin-releasing hormone ; IQR ; interquartile range ; MAOI ; monoamine oxidase inhibitor ; NA ; number of events is not applicable because the outcome is continuous ; NL ; drug is not listed in the PDR ; NMDA ; N-methyl-d-aspartic acid ; NSAID ; nonsteroidal anti-inflammatory drug ; OR ; odds ratio ; PDR ; Phys

刊名：Mayo Clinic Proceedings

出版年：2017

4.Determination of inosine 5′-monophosphate dehydrogenase activity in red blood cells of thiopurine-treated patients using HPLC

作者：Audrey Beringer^a ; ^b ; Antony Citterio-Quentin^a ; ^b ; Rebeca Obenza Otero^a ; Clé ; mence Gustin^a ; ^b ; Rebecca Clarke^a ; ^c ; Jean-Paul Salvi^a ; Roselyne Boulieu^a ; ^b ; ^{roselyne.boulieu@univ-lyon1.fr}

关键词：6-MeMPN ; 6-methyl mercaptopurine nucleotides ; 6-MP ; 6-mercaptopurine ; 6-TGN ; 6-thioguanine nucleotides ; AZA ; azathioprine ; β-NAD ; β-nicotinamide adenine dinucleotide ; DTT ; dithiothreitol ; IBD ; inflammatory bowel disease ; IMP ; inosine 5&prime ; -monophosphate ; IMPDH ; inosine 5&prime ; -monophosphate dehydrogenase ; ITPA ; inosine triphosphate pyrophosphatase ; meTIMP ; methyl thioinisone 5&prime ; -monophosphate ; MPA ; mycophenolic acid ; RBCs ; red blood cells ; TPMT ; thiopurine S-methyltransferase ; XMP ; xant

刊名：Journal of Chromatography B

出版年：2017

5.Prediction of the precipitation profiles of weak base drugs in the small intestine using a simplified transfer (“dumping”) model coupled with in silico modeling and simulation approach

作者：Atsushi Kambayashi^a ; ^b ; ^{atsushi.kanbayashi@astellas.com" class="auth_mail" title="E-mail the corresponding author} ; Takehiko Yasuji^a ; Jennifer B. Dressman^b

关键词：Weak base drugs ; Precipitation ; In silico modeling and simulation ; Luminal concentration in small intestine

刊名：European Journal of Pharmaceutics and Biopharmaceutics

出版年：2016

6.Novel angiotensin-converting enzyme inhibitory peptides from caseins and whey proteins of goat milk

作者：Hisham R. Ibrahim^a ; ^{hishamri@chem.agri.kagoshima-u.ac.jp} ; ^{k2504042@kadai.jp} ; Ahmed S. Ahmed^b ; Takeshi Miyata^a

关键词：GCP ; goat casein proteins ; GWP ; goat whey proteins ; P-GCP ; pepsin digested-GCP ; P-GWP ; pepsin digested-GWP ; ACE ; angiotensin I-converting enzyme ; HHL ; hippuryl-histidyl-leucine ; HA ; hippuric acid ; HL ; histidyl-leucine ; TNBS ; 24 ; 6-trinitrobenzene sulfonate ; TNP- ; 24 ; 6-trinitrophenyl ; MALDI-TOF/MS ; matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

刊名：Journal of Advanced Research

出版年：2017

7.Bis(N-amidinohydrazones) and N-(amidino)-N′-aryl-bishydrazones: New classes of antibacterial/antifungal agents

作者：Sanjib K. Shrestha^a ; Liliia M. Kril^a ; ^b ; Keith D. Green^a ; Stefan Kwiatkowski^b ; ^d ; Vitaliy M. Sviripa^b ; ^c ; Justin R. Nickell^a ; Linda P. Dwoskin^a ; David S. Watt^b ; ^c ; ^d ; ^{dwatt@uky.edu} ; Sylvie Garneau-Tsodikova^a ; ^{sylviegtsodikova@uky.edu}

关键词：Bishydrazones ; Candida albicans ; Cytotoxicity ; hERG channel ; Resistance ; Staphylococcus aureus

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

8.Improved oral absorption profile of itraconazole in hypochlorhydria by self-micellizing solid dispersion approach

作者：Yoshiki Kojo ; Saori Matsunaga ; Hiroki Suzuki ; Hideyuki Sato ; Yoshiki Seto ; Satomi Onoue ; ^{onoue@u-shizuoka-ken.ac.jp}

关键词：ADI ; acceptable daily intake ; AUC ; area under the curve of blood concentration vs. time ; DLS ; dynamic light scattering ; DMEM ; Dulbecco's modified Eagle's medium ; DMSO ; dimethyl sulfoxide ; DSC ; differential scanning calorimetry ; GI ; gastrointestinal ; IEC6 cell ; intestinal epithelioid cell line No.6 derived from neonatal rat ileum ; ITZ ; itraconazole ; LD50 ; lethal dose 50% ; LDH ; lactate dehydrogenase ; NaPB ; sodium phosphate buffer ; PLM ; polarized light microscopy ; PXRD ; powder X-ray diffraction ; RH

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

9.Connections of the Mouse Orbitofrontal Cortex and Regulation of Goal-Directed Action Selection by Brain-Derived Neurotrophic Factor

作者：Kelsey S. Zimmermann^a ; ^b ; ^c ; ^d ; John A. Yamin^a ; ^c ; Donald G. Rainnie^b ; ^c ; ^d ; Kerry J. Ressler^b ; ^c ; ^d ; ^e ; Shannon L. Gourley^a ; ^b ; ^c ; ^d ; ^{shannon.l.gourley@emory.edu}

关键词：Action ; Amygdala ; Habit ; Orbital ; Outcome ; Striatum

刊名：Biological Psychiatry

出版年：2017

10.Co-delivery of doxorubicin and interleukin-2 via chitosan based nanoparticles for enhanced antitumor efficacy

作者：Jingjing Wu ; Cui Tang ; Chunhua Yin ; ^{chyin@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：NN ; N-trimethyl chitosan ; Doxorubicin ; Recombinant ; human ; interleukin-2 ; pH-sensitive modification ; Antitumor efficacy

刊名：Acta Biomaterialia

出版年：2017

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