作者：Ian J. Constable^a ; ^b ; ^c ; Cora M. Pierce^a ; Chooi-May Lai^a ; ^c ; Aaron L. Magno^a ; Mariapia A. Degli-Esposti^a ; ^c ; Martyn A. French^d ; ^e ; Ian L. McAllister^a ; ^b ; ^c ; Steve Butler^f ; Samuel B. Barone^f ; Steven D. Schwartz^g ; Mark S. Blumenkranz^h ; Elizabeth P. Rakoczy^a ; ^c ; ^{Elizabeth.rakoczy@uwa.edu.au}

关键词：Wet age related macular degeneration ; AAV.sFLT-1 ; Gene therapy ; Clinical trial

刊名：EBioMedicine

出版年：2016

作者：Timothy L. Jackson ; PhD ; FRCOphth¹ ; ² ; ^{t.jackson1@nhs.net" class="auth_mail" title="E-mail the corresponding author} ; Riti Desai ; MPhil ; MSc² ; Andrew Simpson ; MBBS ; FRCOphth¹ ; ² ; James E. Neffendorf ; MA ; MBBS¹ ; ² ; Robert Petrarca ; MD (Res) ; FRCOphth¹ ; ² ; Kelly Smith ; MS³ ; Janet Wittes ; PhD³ ; Cornelius Lewis ; PhD¹ ; ⁴ ; Luke Membrey ; MD ; FRCOphth⁵ ; Richard Haynes ; MD ; FRCOphth⁶ ; Mark Costen ; FRCOphth⁷ ; David H.W. Steel ; FRCOphth⁸ ; Alyson Muldrew ; PhD⁹ ; Usha Chakravarthy ; PhD ; FRCOphth⁹ ; on behalf of the Macular Epiretinal Brachytherapy versus Ranibizumab (Lucentis) Only Treatment (MERLOT) Study Group^&lowast ;

关键词：AMD ; age-related macular degeneration ; BCVA ; best-corrected visual acuity ; CABERNET ; Choroidal Neovascularization Secondary to Age-Related Macular Degeneration Treated with Beta Radiation Epiretinal Therapy ; CNV ; choroidal neovascularization ; EMB ; epimacular brachytherapy ; ETDRS ; Early Treatment of Diabetic Retinopathy Study ; INTREPID ; IRay in Conjunction with Anti-VEGF Treatment for Patients with Wet AMD ; MERITAGE ; Macular Epiretinal Brachytherapy in Treated Age-Related Macular Degeneration ; ME

刊名：Ophthalmology

出版年：2016

作者：Xiying Wang^a ; ¹ ; Hongkuan Yang^b ; ^c ; ¹ ; Daijiro Yanagisawa^c ; Jean-Pierre Bellier^c ; Katsutaro Morino^d ; Shiguang Zhao^b ; Ping Liu^a ; ^{pingliu53@126.com" class="auth_mail" title="E-mail the corresponding author} ; Piers Vigers^c ; Ikuo Tooyama^c ; ^{kinchan@belle.shiga-med.ac.jp" class="auth_mail" title="E-mail the corresponding author}

关键词：Mitochondrial ferritin ; Mitochondria ; Age-related macular degeneration ; HIF-1α ; Neurodegeneration

刊名：Neurobiology of Aging

出版年：2016

作者：James S. Talks ; MRCP ; FRCOphth¹ ; ^{james.talks@nuth.nhs.uk" class="auth_mail" title="E-mail the corresponding author} ; Andrew J. Lotery ; MD ; FRCOphth² ; Faruque Ghanchi ; FRCOphth³ ; Sobha Sivaprasad ; FRCOphth⁴ ; Robert L. Johnston ; FRCOphth⁵ ; Nishal Patel ; MD ; FRCOphth⁶ ; Martin McKibbin ; FRCOphth⁷ ; Clare Bailey ; FRCOphth⁸ ; Sajjad Mahmood ; FRCOphth⁹ ; for the United Kingdom Aflibercept Users GroupAires Lobo ; FRCOphth ; FRCS(Ed) ; Bobby Paul ; FRCOphth ; Qureshi Kashif ; FRCOphth ; Cynthia Santiago ; FRCOphth ; Gavin Walters ; MRCP ; FRCOphth ; Mohamed Tahir ; FRCOphth ; Bushra Mushtaq ; FRCOphth

关键词：EMR ; electronic medical record ; nAMD ; neovascular age-related macular degeneration ; PRN ; pro re nata ; VIEW ; VEGF Trap-Eye ; Investigation of Efficacy and Safety in Wet AMD

刊名：Ophthalmology

出版年：2016

作者：Nathan G. Lambert^a ; ^b ; ¹ ; ^{Nathan.lambert@hsc.utah.edu" class="auth_mail" title="E-mail the corresponding author} ; Hanan ElShelmani^c ; ¹ ; ² ; ^{elshelh@tcd.ie" class="auth_mail" title="E-mail the corresponding author} ; Malkit K. Singh^a ; ^b ; ¹ ; ² ; ^{mona.singh@hsc.utah.edu" class="auth_mail" title="E-mail the corresponding author} ; Fiona C. Mansergh^d ; ¹ ; ^{mansergf@tcd.ie" class="auth_mail" title="E-mail the corresponding author} ; Michael A. Wride^c ; ¹ ; ^{wridem@tcd.ie" class="auth_mail" title="E-mail the corresponding author} ; Maximilian Padilla^a ; ^b ; ¹ ; ^{maximilianrpadilla413@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; David Keegan^e ; ¹ ; ^{djkeegan71@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ruth E. Hogg^f ; ¹ ; ^{r.e.hogg@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Balamurali K. Ambati^a ; ^b ; ¹ ; ^{bala.ambati@utah.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Age-related macular degeneration ; Biomarkers ; Proteomics ; microRNA ; sFlt

刊名：Progress in Retinal and Eye Research

出版年：2016

作者：Sleiman Abou-Ltaif ^{Dr.sleiman@gmail.com}

关键词：Ranibizumab ; Aflibercept ; Age-related macular degeneration

刊名：Saudi Journal of Ophthalmology

出版年：2016

作者：Yao Tong ; M.D.^a ; ^b ; Ya-Li Zhou ; M.D.^a ; Yi-Xiao Wang ; M.D.^a ; Pei-Quan Zhao ; M.D.^b ; Zhao-Yang Wang ; M.D. ; PhD^a ; ^{zhaokekewzy@hotmail.com" class="auth_mail" title="E-mail the corresponding author}

刊名：Medical Hypotheses

出版年：2016

作者：M.R. Moreno^a ; ^{mmoreno@ntu.edu.sg" class="auth_mail" title="E-mail the corresponding author} ; T.S. Tabitha^a ; J. Nirmal^a ; K. Radhakrishnan^a ; C.H. Yee^a ; S. Lim^c ; S. Venkatraman^a ; R. Agrawal^b ; ^{rupesh_agrawal@ttsh.com.sg" class="auth_mail" title="E-mail the corresponding author}

关键词：Anti-vascular endothelial growth factor (VEGF) proteins ; Wet age related macular degeneration (AMD) ; Diabetic macular edema (DME) ; Biophysical characterization ; Stability ; Aggregation state ; Excipients ; Emulsion

刊名：European Journal of Pharmaceutics and Biopharmaceutics

出版年：2016

作者：Zaid Mammo^a ; Michael Guo^b ; David Maberley^a ; ^c ; Joanne Matsubara^a ; Mahyar Etminan^a ; ^b ; ^c ; ^{etminanm@mail.ubc.ca" class="auth_mail" title="E-mail the corresponding author}

刊名：American Journal of Ophthalmology

出版年：2016

作者：Demetrios G. Vavvas ; ^{vavvas@meei.harvard.edu" class="auth_mail" title="E-mail the corresponding author} ; Anthony B. Daniels ; Zoi G. Kapsala ; Jeremy W. Goldfarb ; Emmanuel Ganotakis ; John I. Loewenstein ; Lucy H. Young ; Evangelos S. Gragoudas ; Dean Eliott ; Ivana K. Kim ; Miltiadis K. Tsilimbaris ; Joan W. Miller ; ^{joan_miller@meei.harvard.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：AMD ; Statins ; High-dose ; Reversal ; Soft-drusen ; Vision gain

刊名：EBioMedicine

出版年：2016