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在“Elsevier电子期刊”中，命中：126条，耗时：0.051975 秒

在所有数据库中总计命中：187条

1.Assessment of the Blood-Brain Barrier Permeability of Potential Neuroprotective Aurones in Parallel Artificial Membrane Permeability Assay and Porcine Brain Endothelial Cell Models

作者：Kok-Fui Liew¹ ; Nur Aziah Hanapi² ; Kit-Lam Chan¹ ; Siti R. Yusof² ; Chong-Yew Lee¹ ; ^{chongyew@usm.my}

关键词：blood-brain barrier ; permeability ; in vitro models ; CNS ; drug-like properties ; drug design

刊名：Journal of Pharmaceutical Sciences

出版年：2017

2.In vitro blood-brain barrier permeability predictions for GABA_A receptor modulating piperine analogs

作者：Daniela Elisabeth Eigenmann^a ; Carmen Dü ; rig^a ; Evelyn Andrea Jä ; hne^a ; Martin Smie&scaron ; ko^b ; Maxime Culot^c ; Fabien Gosselet^c ; Romeo Cecchelli^c ; Hans Christian Cederberg Helms^d ; Birger Brodin^d ; Laurin Wimmer^e ; Marko D. Mihovilovic^e ; Matthias Hamburger^a ; Mouhssin Oufir^a ; ^{mouhssin.oufir@unibas.ch" class="auth_mail" title="E-mail the corresponding author}

关键词：BBB ; blood&ndash ; brain barrier ; BLEC ; human brain-like endothelial cells ; BSA ; bovine serum albumin ; CCL ; cell layer capacitance ; CNS ; central nervous system ; CV ; coefficient of variation ; DMEM ; Dulbecco&rsquo ; s Modified Eagle Medium ; ER ; efflux ratio ; FA ; formic acid ; FBS ; fetal bovine serum ; GABAA receptor ; γ-aminobutyric acid type A receptor ; hBMEC ; human brain microvascular endothelial cell line ; I.S. ; internal standard ; LLOQ ; lower limit of quantification ; MRM ; multiple reaction monitoring

刊名：European Journal of Pharmaceutics and Biopharmaceutics

出版年：2016

3.Plasma protein binding limits the blood brain barrier permeation of the pyrethroid insecticide, deltamethrin

作者：Manoj Amaraneni ; Anshika Sharma ; Jing Pang ; Srinivasa Muralidhara ; Brian S. Cummings ; Catherine A. White ; James V. Bruckner ; Jason Zastre ; ^{jzastre@uga.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Blood-Brain barrier ; Insecticide ; Pyrethroid ; P-glycoprotein ; Transport

刊名：Toxicology Letters

出版年：2016

4.Blood-brain barrier transport kinetics of the cyclic depsipeptide mycotoxins beauvericin and enniatins

作者：Lien Taevernier^a ; Nathalie Bracke^a ; Lieselotte Veryser^a ; Evelien Wynendaele^a ; Bert Gevaert^a ; Kathelijne Peremans^b ; Bart De Spiegeleer^a ; ^{Bart.DeSpiegeleer@ugent.be" class="auth_mail" title="E-mail the corresponding author}

关键词：Beauvericin ; Enniatins ; Blood-brain barrier permeability ; Cyclic depsipeptide mycotoxins ; in vivo mice model

刊名：Toxicology Letters

出版年：2016

5.Designing the angiogenic inhibitor for brain tumor via disruption of VEGF and IL17A expression

作者：Md Shamsuddin Sultan Khan^a ; ^{jupitex@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Amin Malik Shah Abdul Majid^a ; ^{aminmalikshah@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Muhammad Adnan Iqbal^b ; Aman Shah Abdul Majid^a ; ^c ; Majed Al-Mansoub^a ; Rosenani S.M. Anwarul Haque^b

关键词：Glioblastoma ; Blood&ndash ; brain-barrier ; IL17A ; VEGF ; P-gp

刊名：European Journal of Pharmaceutical Sciences

出版年：2016

6.Quantitative aspects of drug permeation across in vitro and in vivo barriers

作者：Stefanie D. Krä ; mer ; ^{stefanie.kraemer@pharma.ethz.ch" class="auth_mail" title="E-mail the corresponding author}

关键词：A ; Barrier area ; C ; Concentration ; C(0) ; Concentration at start (t ; = ; 0) ; Cd ; Concentration in the donor compartment ; Ceq ; Concentration at equilibrium ; Cr ; Concentration in the receiver compartment ; CBF ; Cerebral blood flow ; CPF ; Cerebral plasma flow ; CL ; Clearance (Table 1) ; D ; Dose ; E ; Extraction coefficient ; F ; Bioavailability ; Hkt ; Haematocrit ; J ; Flux density of mass (Table 1) ; k ; Rate constant (Table 1) ; K1 ; Clearance from plasma to brain (Table 1) ; kai ; Rate constant of permeati

刊名：European Journal of Pharmaceutical Sciences

出版年：2016

7.A new PAMPA model using an in-house brain lipid extract for screening the blood-brain barrier permeability of drug candidates

作者：Joana Bicker^a ; ^b ; Gilberto Alves^b ; ^c ; Ana Fortuna^a ; ^b ; Patrí ; cio Soares-da-Silva^d ; ^e ; Amí ; lcar Falcã ; o^a ; ^b ; ^{acfalcao@ff.uc.pt" class="auth_mail" title="E-mail the corresponding author} ; ^{acfalcao@uc.pt" class="auth_mail" title="E-mail the corresponding author}

关键词：Entacapone (PubChem CID ; 5281081) ; Eslicarbazepine acetate (PubChem CID ; 179344) ; Etamicastat (PubChem CID ; 10450387) ; S-licarbazepine (PubChem CID ; 114709) ; Nebicapone (PubChem CID ; 9838389) ; Nepicastat hydrochloride (PubChem CID ; 9840545) ; Opicapone (PubChem CID ; 76966913) ; Tolcapone (PubChem CID ; 4659569) ; Zamicastat (PubChem CID ; 25156755)

刊名：International Journal of Pharmaceutics

出版年：2016

8.Design, synthesis and evaluation of novel ferulic acid-memoquin hybrids as potential multifunctional agents for the treatment of Alzheimer’s disease

作者：Wanli Pan^a ; Ke Hu^b ; Ping Bai^c ; Lintao Yu^a ; Qinge Ma^a ; Tao Li^a ; Xu Zhang^a ; Changzhong Chen^a ; Kelin Peng^a ; Wenmin Liu^a ; ^{liuwm1969@163.com" class="auth_mail" title="E-mail the corresponding author} ; Zhipei Sang^a ; ^{sangzhipei@163.com" class="auth_mail" title="E-mail the corresponding author}

关键词：AD ; Alzheimer&rsquo ; s disease ; AChE ; acetylcholinesterase ; BuChE ; butyrylcholinesterase ; Aβ ; β-amyloid peptide ; BBB ; blood&ndash ; brain barrier ; ACh ; acetylcholine ; MTDL ; multitarget-directed ligand ; EeAChE ; electric eel AChE ; CAS ; catalytic anionic site ; PAS ; peripheral anionic site ; ORAC-FL ; Oxygen Radicals Absorbance Capacity by Fluorescence ; ThT ; thioflavin T ; PAMPA-BBB ; parallel artificial membrane permeation assay of the blood&minus ; brain barrier

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

9.Delivery of Copper-chelating Trientine (TETA) to the central nervous system by surface modified liposomes

作者：Robin Tremmel^a ; Philipp Uhl^b ; Frieder Helm^a ; Dominik Wupperfeld^a ; Max Sauter^b ; Walter Mier^b ; Wolfgang Stremmel^b ; Gö ; tz Hofhaus^c ; Gert Fricker^a ; ^{gert.fricker@uni-hd.de" class="auth_mail" title="E-mail the corresponding author}

关键词：Trientine ; Blood brain barrier ; Liposome ; Cationized albumin ; Apolipoprotein E ; Penetratin ; Copper ; TETA

刊名：International Journal of Pharmaceutics

出版年：2016

10.Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer’s disease based on the fusion of donepezil and melatonin

作者：Jin Wang ; Zhi-Min Wang ; Xue-Mei Li ; Fan Li ; Jia-Jia Wu ; Ling-Yi Kong ; ^{cpu_lykong@126.com" class="auth_mail" title="E-mail the corresponding author} ; Xiao-Bing Wang ; ^{xbwang@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：AchE ; Acetylcholinesterase ; BuChE ; Butyrylcholinesterase ; AD ; Alzheimer&rsquo ; s disease ; Aβ ; β-Amyloid ; CAS ; Catalytic anionic site ; PAS ; Peripheral anionic site ; BBB ; Blood&ndash ; brain barrier ; AβOs ; Soluble Aβ oligomers ; CNS ; Central nervous system ; NFTS ; Neurofibrillary tangles ; ChEs ; Cholinesterases ; ChEIs ; Cholinesterase inhibitors ; CDI ; 1 ; 1&prime ; -Carbonyldiimidazole ; ORAC ; Oxygen radical absorbance capacity ; PAMPA ; Parallel artificial membrane permeation assay

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

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