搜索页_ shinkichi.ishikawa@jt.com

常用资源

电子图书

期刊论文

学位会议

在“Elsevier电子期刊”中，命中：96条，耗时：小于0.01 秒

在所有数据库中总计命中：120条

1.Repeated whole cigarette smoke exposure alters cell differentiation and augments secretion of inflammatory mediators in air-liquid interface three-dimensional co-culture model of human bronchial tissue

作者：Shinkichi Ishikawa ; ^{shinkichi.ishikawa@jt.com} ; Shigeaki Ito

关键词：3D ; three-dimensional ; AEGM ; Airway Epithelial Cell Growth Medium ; ALI ; air-liquid interface ; CS ; cigarette smoke ; CSE ; cigarette smoke extract ; COPD ; chronic obstructive pulmonary disease ; CYP ; cytochrome P450 ; FBS ; fetal bovine serum ; HBECs ; human bronchial epithelial cells ; ISO ; International Organization for Standardization ; LDH ; lactate dehydrogenase ; MEM ; minimum essential medium ; OECD ; Organization for Economic Co-operation and Development

刊名：Toxicology in Vitro

出版年：2017

2.1,2,3-Triazolyl ester of Ketorolac: A “Click Chemistry”-based highly potent PAK1-blocking cancer-killer

作者：Binh Cao Quan Nguyen^a ; ^c ; ¹ ; Hideaki Takahashi^b ; ¹ ; Yoshihiro Uto^b ; ; M.d. Shahinozzaman^a ; ^c ; Shinkichi Tawata^a ; Hiroshi Maruta^a ; ^d ; ^{maruta20420@yahoo.co.jp}

关键词：PAK1 ; COX-2 ; Ketorolac ; Click chemistry ; Triazole ring ; Cancer

刊名：European Journal of Medicinal Chemistry

出版年：2017

3.Transcanal endoscopic resection for leiomyoma of the external auditory canal and a review of the literature

作者：Ryoukichi Ikeda^a ; ^{ryoukich@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Masaru Tateda^a ; Akira Okoshi^a ; Shinkichi Morita^a ; Hiroyoshi Suzuki^b ; Sho Hashimoto^a

关键词：Leiomyoma ; External auditory canal ; Transcanal endoscopic ear surgery ; Arrectores pilorum muscles ; Auricular fullness

刊名：Auris Nasus Larynx

出版年：2016

4.Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors

作者：Yasuhiro Imaeda^a ; ^{yasuhiro.imaeda@takeda.com" class="auth_mail" title="E-mail the corresponding author} ; Michiko Tawada^a ; Shinkichi Suzuki^a ; Masaki Tomimoto^a ; Mitsuyo Kondo^a ; Naoki Tarui^a ; Tsukasa Sanada^a ; Ray Kanagawa^a ; Gyorgy Snell^b ; Craig A. Behnke^b ; ^&dagger ; ; Keiji Kubo^a ; Takanobu Kuroita^a

关键词：AcOH ; acetic acid ; Ang I ; angiotensin I ; Ang II ; angiotensin II ; AUC ; area under the blood concentration&ndash ; time curve ; C5min ; concentration in plasma 5 ; min after administration ; CLtotal ; total clearance ; Cmax ; maximum concentration in plasma ; DIEA ; N ; N-diisopropylethylamine ; Et3N ; triethylamine ; EtOAc ; ethyl acetate ; EtOH ; ethanol ; F ; rat bioavailability ; HAC ; heavy atom count ; HOBt ; 1-hydroxybenzotriazole hydrate ; hPRA ; human plasma renin activity ; i-PrOH ; isopropanol ; LE ; ligand effic

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

5.Novel approach of fragment-based lead discovery applied to renin inhibitors

作者：Michiko Tawada^a ; ^{michiko.tawada@takeda.com" class="auth_mail" title="E-mail the corresponding author} ; Shinkichi Suzuki^a ; Yasuhiro Imaeda^a ; Hideyuki Oki^a ; Gyorgy Snell^b ; Craig A. Behnke^b ; ^&dagger ; ; Mitsuyo Kondo^a ; Naoki Tarui^a ; Toshimasa Tanaka^a ; Takanobu Kuroita^a ; Masaki Tomimoto^a

关键词：Fragment-based drug discovery (FBDD) ; High-throughput synthetic chemistry ; Structure-based drug design (SBDD) ; Renin inhibitor ; Crystal structure

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

6.Clinical implications of sarcopenia in patients undergoing complete resection for early non-small cell lung cancer

作者：Yuzo Suzuki ; Tatsuro Okamoto ; MD ; PhD ; ^{tatsuro@surg2.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; ^{tatsuro@surg2.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Takatoshi Fujishita ; Masakazu Katsura ; Takaki Akamine ; Shinkichi Takamori ; Yosuke Morodomi ; Tetsuzo Tagawa ; Fumihiro Shoji ; Yoshihiko Maehara

关键词：Sarcopenia ; Non-small cell lung cancer ; Computed tomography ; Prognosis

刊名：Lung Cancer

出版年：2016

7.Assessing the mutagenic activities of smoke from different cigarettes in direct exposure experiments using the modified Ames Salmonella assay

作者：Shinkichi Ishikawa ; ^{shinkichi.ishikawa@jt.com" class="auth_mail" title="E-mail the corresponding author} ; Yuki Kanemaru ; Hidenori Nara ; Kazuo Erami ; Yasufumi Nagata

关键词：AC ; air-exposed condition ; CC1 ; conventional 1 ; mg tar commercial cigarette ; CS ; cigarette smoke ; df ; dilution factor ; GVP ; gas/vapor phase ; HC ; heated cigarette ; HCI ; Health Canada intensive smoking regimen ; ISO ; International Organization for Standardization smoking regimen ; PP ; particulate phase ; TPM ; total particulate matter

刊名：Mutation Research/Genetic Toxicology and Environmental Mutagenesis

出版年：2016

8.Predictive impact for postoperative recurrence using the preoperative prognostic nutritional index in pathological stage I non-small cell lung cancer

作者：Fumihiro Shoji ; ^{fshoji@surg2.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Yosuke Morodomi ; Takaki Akamine ; Shinkichi Takamori ; Masakazu Katsura ; Kazuki Takada ; Yuzo Suzuki ; Takatoshi Fujishita ; Tatsuro Okamoto ; Yoshihiko Maehara

关键词：AUC ; area under the curve ; BVI ; blood vessel invasion ; CEA ; carcino embryonic antigen ; CT ; computed tomography ; CYFRA ; cytokeratin 19 fragment ; FDG-PET ; fluorodeoxyglucose-positron emission tomography ; LVI ; lymphatic vessel invasion ; MRI ; magnetic resonance imaging ; NCCN ; National Comprehensive Cancer Network ; NSCLC ; non-small-cell lung cancer ; PNI ; prognostic nutritional index ; RFS ; recurrence-free survival ; ROC ; receiver operating characteristics ; RR ; relative risk ; UFT ; uracil-tegafur chemoth

刊名：Lung Cancer

出版年：2016

9.Structure-based discovery of cellular-active allosteric inhibitors of FAK

作者：Naoki Tomita^a ; ^{naoki.tomita@takeda.com} ; Yoko Hayashi^a ; Shinkichi Suzuki^a ; Yoshimasa Oomori^b ; Yoshio Aramaki^a ; Yoshihiro Matsushita^a ; Misa Iwatani^a ; Hidehisa Iwata^a ; Atsutoshi Okabe^a ; Yoshiko Awazu^a ; Osamu Isono^a ; Robert J. Skene^c ; David J. Hosfield^c ; ^&dagger ; ; Hiroshi Miki^a ; Tomohiro Kawamoto^a ; Akira Hori^a ; Atsuo Baba^a

关键词：ISXAVIPPPMJTPN-UHFFFAOYSA-N ; ASUBFYXRDNJNOB-UHFFFAOYSA-N ; LWMFYSSKMYKGNI-UHFFFAOYSA-N ; PXRULJZQXIUNTM-UHFFFAOYSA-N ; RLXHHNOPSKGTDC-UHFFFAOYSA-N ; FADYFQASOSLUAS-UHFFFAOYSA-N ; CVWIHCVTHLIUHE-UHFFFAOYSA-N ; VKHQVZALROIDPM-UHFFFAOYSA-N ; OGZWVPNHAPBIHM-UHFFFAOY

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2013

10.Disruption of aldehyde dehydrogenase 2 gene results in altered cortical bone structure and increased cortical bone mineral density in the femoral diaphysis of mice

作者：Takuto Tsuchiya^a ; ^{t_takuto67@yahoo.co.jp} ; Akinori Sakai^a ; ^{a-sakai@med.uoeh-u.ac.jp} ; Kunitaka Menuki^a ; ^{menuki@med.uoeh-u.ac.jp} ; Toshiharu Mori^a ; ^{shunyou@med.uoeh-u.ac.jp} ; Yoshinori Takeuchi^a ; ^{ytakeuchi1978@gmail.com} ; Shinkichi Kanoh^a ; ^{k_shinkichi@hotmail.com} ; Hajime Utsunomiya^a ; ^{hajime_utsu@hotmail.com} ; Teppei Murai^a ; ^{t-murai@med.uoeh-u.ac.jp} ; Toyohi Isse^b ; ^{isse@med.uoeh-u.ac.jp} ; Toshihiro Kawamoto^b ; ^{kawamott@med.uoeh-u.ac.jp} ; Toshitaka Nakamura^a ; ^{toshinak@med.uoeh-u.ac.jp}

关键词：ALDH2 ; aldehyde dehydrogenase 2 ; aldh2+/+ mice ; wild-type mice ; aldh2&minus ; /&minus ; mice ; aldh2 ; knockout mice ; BMD ; bone mineral density ; pQCT ; peripheral quantitative computed tomography ; sLS ; single-labeled surface ; dLS ; double-labeled surface ; MAR

刊名：Bone

出版年：2013

按检索点细分(96)

题名(1)

作者(95)

按出版年细分(96)

2017年(2)

2016年(6)

2013年(3)

2012年(1)

2011年(5)

2010年(2)

2009年(4)

2008年(3)

2007年(4)

2006年(4)

2005年(6)

2004年(4)

2003年(3)

2002年(8)

2001年(5)

2000年(7)

2000年及以前(29)

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700