搜索页_ ¦Ã-Secretase inhibitor

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在“Elsevier电子期刊”中，命中：49条，耗时：0.0219887 秒

1.The ¦Ã-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl) amino]ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates A¦Â_1-42 seeding and short-term memory deficits in the A¦Â_25-35 mouse model of Alzhei

作者：Johann Meunier^a ; Vanessa Villard^a ; Laurent Givalois^b ; ^c ; ^d ; Tangui Maurice^b ; ^c ; ^d ; ^{maurice@univ-montp2.fr}

关键词：Alzheimer's disease ; Amyloid-¦Â peptide ; ¦Ã-secretase inhibitor ; Amyloid protein seeding ; Drug discovery

刊名：European Journal of Pharmacology

出版年：2013

2.¦Ã-Secretase inhibitors and modulators

作者：Todd E. Golde ; Edward H. Koo ; Kevin M. Felsenstein ; Barbara A. Osborne ; Lucio Miele

关键词：¦Ã-Secretase inhibitor ; ¦Ã-Secretase modulator ; Cancer ; Alzheimer's disease

刊名：Biochimica et Biophysica Acta (BBA)/Biomembranes

出版年：2013

3.An improved cell-based method for determining the ¦Ã-secretase enzyme activity against both Notch and APP substrates

作者：Timothy D. McKee ; ^{Tim.Mckee@satoripharma.com} ; Robyn M.B. Loureiro ; Jo Ann Dumin ; Vladislav Zarayskiy ; Barbara Tate

关键词：GSI ; ¦Ã-secretase inhibitor ; GSM ; ¦Ã-secretase modulator ; NICD ; Notch intracellular domain ; ¦Â-Amyloid ; A¦Â ; 2B ; 7CHO-2B7

刊名：Journal of Neuroscience Methods

出版年：2013

4.Structure activity relationship studies of tricyclic bispyran sulfone ¦Ã-secretase inhibitors

作者：Wen-Lian Wu ; ^{wen-lian.wu@merck.com} ; Theodros Asberom ; Thomas Bara ; Chad Bennett ; Duane A. Burnett ; John Clader ; Martin Domalski ; William J. Greenlee ; Hubert Josien ; Mark McBriar ; Murali Rajagopalan ; Monica Vicarel ; Ruo Xu ; Lynn A. Hyde ; Robert A. Del Vecchio ; Mary E. Cohen-Williams ; Lixin Song ; Julie Lee ; Giuseppe Terracina ; Qi Zhang ; Amin Nomeir ; Eric M. Parker ; Lili Zhang

关键词：Alzheimer&rsquo ; s disease ; ¦Ã-Secretase inhibitor ; Structure activity relationship ; Sulfone

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2013

5.Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious ¦Ã-secretase inhibitors

作者：Xiaocong M. Ye^a ; ^{mxcye@hotmail.com} ; Andrei W. Konradi^a ; Minghua Sun^a ; ^&dagger ; ; Shendong Yuan^a ; Danielle L. Aubele^a ; Michael Dappen^a ; Darren Dressen^a ; Albert W. Garofalo^a ; Jacek J. Jagodzinski^a ; Lee Latimer^a ; Gary D. Probst^a ; Hing L. Sham^a ; David Wone^a ; Ying-zi Xu^a ; Daniel Ness^b ; Elizabeth Brigham^b ; Grace T. Kwong^b ; Chris Willtis^b ; George Tonn^c ; Erich Goldbach^c ; Kevin P. Quinn^c ; Hongbin H. Zhang^c ; John-Michael Sauer^c ; Michael Bova^d ; Guriqbal S. Basi^e ; ^&Dagger ;

关键词：Alzheimer&rsquo ; s disease ; Amyloid precursor protein ; ¦Ã-Secretase ; ¦Ã-Secretase inhibitor ; Notch

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2013

6.Modification of a promiscuous inhibitor shifts the inhibition from ¦Ã-secretase to FLT-3

作者：Ghislaine Marlyse Okala Amombo^a ; ^&dagger ; ; Thomas Kramer^a ; ^&dagger ; ; Fabio Lo Monte^a ; ^&dagger ; ; Stefan Gö ; ring^a ; Matthias Fach^a ; Steven Smith^a ; Stephanie Kolb^a ; Robert Schubenel^b ; Karlheinz Baumann^b ; Boris Schmidt^a ; ^{Schmidt_boris@t-online.de}

关键词：Acute myeloid leukemia ; FLT-3 ; Kinase inhibitor ; ¦Ã-Secretase

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

7.A-ring modification of SCH 900229 and related chromene sulfone ¦Ã-secretase inhibitors

作者：Wen-Lian Wu ; ^{wen-lian.wu@merck.com} ; Thavalakulamgara K. Sasikumar ; Martin S. Domalski ; Li Qiang ; Duane A. Burnett ; John Clader ; William J. Greenlee ; Tze-Ming Chan ; Julie Lee ; Lili Zhang

关键词：Alzheimer&rsquo ; s disease ; ¦Ã-Secretase inhibitor ; SCH 900229 ; Difluoroquinone

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2013

8.Erlin-2 is associated with active ¦Ã-secretase in brain and affects amyloid ¦Â-peptide production

作者：Yasuhiro Teranishi ; Ji-Yeun Hur ; Gucci Jijuan Gu ; Takahiro Kihara ; Taizo Ishikawa ; Takeshi Nishimura ; Bengt Winblad ; Homira Behbahani ; Masood Kamali-Moghaddam ; Susanne Frykman ; Lars O. Tjernberg

关键词：A¦Â ; amyloid ¦Â-peptide ; ACN ; acetonitrile ; AD ; Alzheimer disease ; AICD ; APP intracellular domain ; APP ; A¦Â precursor protein ; FA ; formic acid ; GCB ; ¦Ã-secretase inhibitor coupled to biotin via a cleavable linker ; GSAPs ; ¦Ã-secretase associated proteins

刊名：Biochemical and Biophysical Research Communications

出版年：2012

9.ALDH⁺ tumor-initiating cells exhibiting gain in NOTCH1 gene copy number have enhanced regrowth sensitivity to a ¦Ã-secretase inhibitor and irinotecan in colorectal cancer

作者：John J. Arcaroli^a ; Rebecca W. Powell^a ; Marileila Varella-Garcia^a ; Martine McManus^b ; Aik Choon Tan^a ; Kevin S. Quackenbush^a ; Todd M. Pitts^a ; Dexiang Gao^c ; Anna Spreafico^a ; Arvind Dasari^a ; Basel M. Touban^a ; Wells A. Messersmith^a ; ^{Wells.Messersmith@ucdenver.edu}

关键词：Notch ; Cancer stem cell ; Gamma-secretase inhibitor ; Colorectal cancer

刊名：Molecular Oncology

出版年：2012

10.Multicenter, Randomized, Double-Blind, Placebo-Controlled, Single-Ascending Dose Study of the Oral ¦Ã-Secretase Inhibitor BMS-708163 (Avagacestat): Tolerability Profile, Pharmacokinetic Parameters, and Pharmacodynamic Markers

作者：Gary Tong ; MD ; PhD¹ ; ^{Gary.Tong@bms.com} ; Jun-Sheng Wang ; PhD¹ ; Oleksandr Sverdlov ; PhD² ; Shu-Pang Huang ; PhD² ; Randy Slemmon ; PhD¹ ; Robert Croop ; MD² ; Lorna Castaneda ; MS¹ ; Huidong Gu ; MS² ; Oi Wong ; BS² ; Hewei Li ; MD ; PhD² ; Robert M. Berman ; MD³ ; Christina Smith ; DPhil² ; Charles F. Albright ; PhD³ ; Randy C. Dockens ; PhD¹

关键词：avagacestat ; Alzheimer's disease ; A¦Â1&ndash ; 40 ; gamma-secretase inhibitor ; pharmacodynamic ; pharmacokinetic ; tolerability

刊名：Clinical Therapeutics

出版年：2012

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