搜索页_ 5-HT6 antagonist

常用资源

电子图书

期刊论文

学位会议

在“Elsevier电子期刊”中，命中：65条，耗时：小于0.01 秒

在所有数据库中总计命中：237条

1.The 5-HT₆ receptor antagonist idalopirdine potentiates the effects of donepezil on gamma oscillations in the frontal cortex of anesthetized and awake rats without affecting sleep-wake architecture

作者：Maria Amat-Foraster^a ; ¹ ; ^{maaf@lundbeck.com} ; Steven C. Leiser^d ; ¹ ; ^{stevenleiser@gmail.com} ; Kjartan F. Herrik^a ; ^{kfh@lundbeck.com} ; Nelly Richard^a ; ^{nelly-richard@hotmail.com} ; Claus Agerskov^a ; ^{clsg@lundbeck.com} ; Christoffer Bundgaard^b ; ^{cbun@lundbeck.com} ; Jesper F. Bastlund^a ; ^{jfb@lundbeck.com} ; Inge E.M. de Jong^c ; ^{idj@lundbeck.com}

关键词：5-HT6 receptor ; Idalopirdine ; Acetylcholinesterase inhibitor ; EEG ; sleep ; Alzheimer's disease

刊名：Neuropharmacology

出版年：2017

2.Design and synthesis of novel N-sulfonyl-2-indoles that behave as 5-HT₆ receptor ligands with significant selectivity for D₃ over D₂ receptors

作者：Oscar M. Saavedra^a ; Delphine Karila^a ; Dominique Brossard^a ; Anne Rojas^b ; Delphine Dupuis^c ; Arnaud Gohier^d ; Clotilde Mannoury la Cour^c ; Mark J. Millan^c ; ; Jean-Claude Ortuno^b ; ; Stephen Hanessian^a ;

关键词：Benzocyclobutane ; Indole ; CNS receptors ; Schizophrenia ; Antipsychotic

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

3.Optimization of N‿(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT₆ antagonistic binding pocket

作者：Arnold van Loevezijn^&dagger ; ; ^&Dagger ; ; Jennifer Venhorst ; ^&dagger ; ; ^§ ; ; ^{jennifer.mccormack@tno.nl" class="auth_mail" title="E-mail the corresponding author} ; Wouter I. Iwema Bakker^¶ ; ; Jos H.M. Lange^‖ ; Wouter de Looff^&dagger ; &dagger ; ; Remco Henzen ; Jelle de Vries^&Dagger ; &Dagger ; ; Rob P. van de Woestijne ; Arnold P. den Hartog^§ ; § ; ; Stefan Verhoog^¶ ; ¶ ; ; Martina A.W. van der Neut^‖‖ ; Natasja M.W.J. de Bruin^&dagger ; &dagger ; &dagger ; ; Chris G. Kruse^&Dagger ; &Dagger ; &Dagger ;

关键词：5-HT6 receptor ; N&prime ; -(Arylsulfonyl)pyrazoline-1-carboxamidines ; Non-basic 5-HT6 antagonists ; Molecular modeling

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

4.1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT₆ receptor antagonists

作者：Charles-Henry Fabritius^a ; Ullamari Pesonen^b ; Josef Messinger^b ; Raymond Horvath^a ; Harri Salo^b ; Michał Gałęzowski^a ; Mariusz Galek^a ; Klaudia Stefańska^a ; Joanna Szeremeta-Spisak^a ; Marta Olszak-Płachta^a ; Anna Buda^a ; Justyna Adamczyk^a ; Marcin Kró ; l^a ; Peteris Prusis^b ; Magdalena Sieprawska-Lupa^a ; Maciej Mikulski^a ; Katja Kuokkanen^b ; Hugh Chapman^b ; Radosław Obuchowicz^a ; Timo Korjamo^b ; Niina Jalava^b ; Mateusz Nowak^a ; ^{mateusz.nowak@selvita.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Serotonin receptor ; 5-HT6 receptor ; Antagonists ; Azaindole ; Cognitive impairment

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

5.Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT₆ receptor antagonists. Design, synthesis and biological evaluation

作者：Anna Więckowska^a ; ^{anna.wieckowska@uj.edu.pl" class="auth_mail" title="E-mail the corresponding author} ; Marcin Kołaczkowski^b ; Adam Bucki^b ; Justyna Godyń^a ; Monika Marcinkowska^b ; Krzysztof Więckowski^c ; Paula Zaręba^a ; Agata Siwek^d ; Grzegorz Kazek^e ; Monika Głuch-Lutwin^d ; Paweł Mierzejewski^f ; Przemysław Bienkowski^f ; Halina Sienkiewicz-Jarosz^f ; Damijan Knez^g ; Tomasz Wichur^a ; Stanislav Gobec^g ; Barbara Malawska^a

关键词：Alzheimer's disease ; Multi-target-directed ligands ; Acetylcholinesterase inhibitors ; Butyrylcholinesterase inhibitors ; 5-HT6 receptor antagonists

刊名：European Journal of Medicinal Chemistry

出版年：2016

6.Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT₄R) partial agonist and 5-HT₆R antagonist activities, as potential treatment of Alzheimer’s disease

作者：Samir Yahiaoui^a ; Katia Hamidouche^b ; Cé ; line Ballandonne^a ; Audrey Davis^a ; Jana Sopkova de Oliveira Santos^a ; Thomas Freret^b ; Michel Boulouard^b ; Christophe Rochais^a ; ^{christophe.rochais@unicaen.fr" class="auth_mail" title="E-mail the corresponding author} ; Patrick Dallemagne^a ; ^{patrick.dallemagne@unicaen.fr" class="auth_mail" title="E-mail the corresponding author}

关键词：Alzheimer&rsquo ; s disease ; MTDL ; 5-HT4 receptors agonists ; 5-HT6 receptors antagonists

刊名：European Journal of Medicinal Chemistry

出版年：2016

7.The 5-HT₆ receptor antagonist idalopirdine potentiates the effects of acetylcholinesterase inhibition on neuronal network oscillations and extracellular acetylcholine levels in the rat dorsal hippocampus

作者：Kjartan F. Herrik^a ; ^{kfh@lundbeck.com" class="auth_mail" title="E-mail the corresponding author} ; Arne Mø ; rk^a ; ^{arm@lundbeck.com" class="auth_mail" title="E-mail the corresponding author} ; Nelly Richard^a ; ^{nelly-richard@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Christoffer Bundgaard^b ; ^{cbun@lundbeck.com" class="auth_mail" title="E-mail the corresponding author} ; Jesper F. Bastlund^a ; ^{jfb@lundbeck.com" class="auth_mail" title="E-mail the corresponding author} ; Inge E.M. de Jong^c ; ^{idj@lundbeck.com" class="auth_mail" title="E-mail the corresponding author}

关键词：5-HT6 receptor ; Idalopirdine ; Donepezil ; Neuronal oscillations ; Acetylcholine ; Alzheimer's disease

刊名：Neuropharmacology

出版年：2016

8.Activation and blockade of serotonin₆ receptors in the dorsal hippocampus enhance T maze and hole-board performance in a unilateral 6-hydroxydopamine rat model of Parkinson's disease

作者：Kun Cheng Liu^a ; Jun Yi Li^a ; Wen Xie^b ; Li Bo Li^c ; Jin Zhang^b ; Cheng Xue Du^b ; Yu Ming Zhang^b ; Hui Hui Tan^c ; Hui Sheng Wang^b ; Li Zhang^b ; ^{zhangli1998@mail.xjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Dorsal hippocampus ; 5-HT6 receptors ; Memory ; Parkinson's disease ; Rat

刊名：Brain Research

出版年：2016

9.Idalopirdine, a 5-HT6 antagonist in Phase III development as adjunctive therapy to cholinesterase inhibitors in patients with mild-to-moderate Alzheimer’s disease: the observed case analyses of the Phase II study

作者：Jeffrey Cummings¹ ; ^{ebrukarakoc@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Kristian Windfeld² ; Tomas Odergren³

刊名：Neurobiology of Aging

出版年：2016

10.Idalopirdine, a 5-HT6 receptor antagonist in development for the treatment of mild-moderate Alzheimer’s disease: the scientific rationale

作者：Inge de Jong¹ ; ^{IDJ@Lundbeck.com" class="auth_mail" title="E-mail the corresponding author} ; Kjartan Herrik¹ ; Lone Helboe¹ ; Maria Amat Foraster¹ ; Gennady Smagin² ; Steven Leiser² ; Craig Ferris³ ; Arne Mø ; rk¹

刊名：Neurobiology of Aging

出版年：2016

按检索点细分(65)

题名(24)

关键词(19)

文摘(11)

按出版年细分(65)

2017年(2)

2016年(9)

2015年(2)

2013年(6)

2012年(10)

2011年(16)

2010年(3)

2009年(6)

2008年(2)

2007年(1)

2006年(2)

2005年(1)

2002年(1)

2000年及以前(4)

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700