作者：Antonio J. Ruiz-Alcaraz^a ; ^ajruiz@um.es ; Marí ; a Tristá ; n-Manzano^a ; Antonio Guirado^b ; Jesú ; s Gá ; lvez^c ; Marí ; a Martí ; nez-Esparza^a ; Pilar Garcí ; a-Peñ ; arrubia^a ; ^{pigarcia@um.es}

关键词：ATF ; activating transcription factor ; CCM ; complete culture medium ; ERK ; extracellular signal-regulated kinase ; IKK ; IκB kinase ; IL-6 ; interleukin 6 ; JNK ; c-Jun N-terminal kinase ; LPS ; lipopolysaccharide ; MAPK ; mitogen-activated protein kinase ; NSAIDs ; non-steroidal anti-inflammatory drugs ; NFκB ; nuclear factor kappa-light-chain-enhancer of activated B cells ; PAMP ; pathogen-associated molecular patterns ; PI3K ; phosphatidylinositol 3-kinase ; PKB ; protein kinase B ; PRRs ; PAMP recognition receptors

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

作者：Gaelle R. Carrat¹ ; Ming Hu¹ ; Marie-Sophie Nguyen-Tu¹ ; Pauline Chabosseau¹ ; Kyle J. Gaulton² ; ³ ; Martijn van de Bunt² ; ⁴ ; Afshan Siddiq⁵ ; Mario Falchi⁵ ; ⁶ ; Matthias Thurner² ; ⁴ ; Mickaë ; l Canouil⁷ ; ⁸ ; Francois Pattou⁷ ; ⁸ ; Isabelle Leclerc¹ ; Timothy J. Pullen¹ ; Matthew C. Cane¹ ; Priyanka Prabhala¹ ; William Greenwald² ; ³ ; Anke Schulte⁹ ; Piero Marchetti¹⁰ ; Mark Ibberson¹¹ ; Patrick E. MacDonald¹² ; Jocelyn E. Manning Fox¹² ; Anna L. Gloyn² ; ⁴ ; ¹³ ; Philippe Froguel⁵ ; ⁷ ; ⁸ ; Michele Solimena¹⁴ ; ¹⁵ ; ¹⁶ ; Mark I. McCarthy² ; ⁴ ; ¹³ ; Guy A. Rutter¹ ; ^{g.rutter@imperial.ac.uk}

关键词：diabetes ; insulin ; islet ; mouse ; genetics ; GWAS ; secretion ; STARD10 ; ARAP1

刊名：The American Journal of Human Genetics

出版年：2017

作者：Paola Vinci¹ ; Antonio Bastone² ; Silvia Schiarea² ; Claudia Cappuzzello¹ ; Annalisa Del Prete³ ; ⁴ ; Erica Dander¹ ; Andrea Biondi¹ ; ⁵ ; ^* ; Giovanna D'Amico¹ ; ^* ; ^{giovanna.damico@hsgerardo.org}

关键词：chemerin ; ChemR23 receptor ; immunomodulation ; mesenchymal stromal cells

刊名：Cytotherapy

出版年：2017

作者：Ulrike Garscha^a ; ¹ ; ^{ulrike.garscha@uni-jena.de" class="auth_mail" title="E-mail the corresponding author} ; Susanna Voelker^a ; ¹ ; ^{susanna.voelker@gmx.de" class="auth_mail" title="E-mail the corresponding author} ; Simona Pace^a ; ^{simona.pace@uni-jena.de" class="auth_mail" title="E-mail the corresponding author} ; Jana Gerstmeier^a ; ^{jana.gerstmeier@uni-jena.de" class="auth_mail" title="E-mail the corresponding author} ; Besa Emini^a ; ^{eminibesa@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Stefanie Liening^a ; ^{stefanie.liening@uni-jena.de" class="auth_mail" title="E-mail the corresponding author} ; Antonietta Rossi^b ; ^{antrossi@unina.it" class="auth_mail" title="E-mail the corresponding author} ; Christina Weinigel^c ; ^{christina.weinigel@med.uni-jena.de" class="auth_mail" title="E-mail the corresponding author} ; Silke Rummler^c ; ^{silke.rummler@med.uni-jena.de" class="auth_mail" title="E-mail the corresponding author} ; Ulrich S. Schubert^d ; ^e ; ^{ulrich.schubert@uni-jena.de" class="auth_mail" title="E-mail the corresponding author} ; Gerhard K.E. Scriba^a ; ^{gerhard.scriba@uni-jena.de" class="auth_mail" title="E-mail the corresponding author} ; Erşan Ç ; elikoğlu^f ; ^{ersancelikoglu@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Burcu Ç ; alışkan^f ; ^{brcaliskan@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Erden Banoglu^f ; ^{banoglu@gazi.edu.tr" class="auth_mail" title="E-mail the corresponding author} ; Lidia Sautebin^b ; ^{sautebin@unina.it" class="auth_mail" title="E-mail the corresponding author} ; Oliver Werz^a ; ^d ; ^{oliver.werz@uni-jena.de" class="auth_mail" title="E-mail the corresponding author}

关键词：5-LO ; 5-lipoxygenase ; AA ; arachidonic acid ; COX ; cyclooxygenase ; cPLA2 ; cytosolic phospholipase A2 ; FLAP ; 5-lipoxygenase-activating protein ; fMLP ; N-formyl-methionyl-leucyl-phenylalanine ; H(P)ETE ; hydro(pero)oxyeicosatetraenoic acid ; HHT ; hydroxyheptadecatrienoic acid ; IL ; interleukin ; LPS ; lipopolysaccharide ; LT ; leukotriene ; mPGES-1 ; microsomal prostaglandin E2 synthase 1 ; MPO ; myeloperoxidase ; PG ; phosphate-buffered saline plus 1  ; mg/ml glucose ; PGC ; phosphate-buffered saline plus 1 

刊名：Biochemical Pharmacology

出版年：2016

作者：Jonathan Scott ; MPhil^a ; Graham J. Harris ; MBBS ; MRes^a ; Emma M. Pinder ; MRCP(UK)^a ; James G. Macfarlane ; MRCP(UK)^a ; Thomas P. Hellyer ; MRCP(UK)^a ; Anthony J. Rostron ; PhD ; FRCP^a ; Andrew Conway Morris ; PhD ; FRCA^b ; David R. Thickett ; DM ; FRCP^c ; Gavin D. Perkins ; MD ; FRCP^d ; Daniel F. McAuley ; MD ; FRCP^e ; ^f ; John D. Widdrington ; MBBS ; MRes^a ; Sarah Wiscombe ; MBChB^a ; Simon V. Baudouin ; MD ; FRCP^g ; Alistair I. Roy ; FFICM^h ; Vanessa C. Linnett ; FRCAⁱ ; Stephen E. Wright ; FRCA^j ; Marie-Hé ; lè ; ne Ruchaud-Sparagano ; PhD^a ; A. John Simpson ; PhD ; FRCP(Edin)^a ; ^{j.simpson@ncl.ac.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：Neutrophil ; β2-agonist ; cyclic AMP ; exchange protein directly activated by cyclic AMP ; hospital-acquired infection

刊名：Journal of Allergy and Clinical Immunology

出版年：2016

作者：Rachel Stegeman¹ ; Peyton J. Spreacker¹ ; Selene K. Swanson² ; Robert Stephenson¹ ; Laurence Florens² ; Michael P. Washburn² ; ³ ; Vikki M. Weake¹ ; ⁴ ; ^{vweake@purdue.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：snRNP ; small nuclear ribonucleoprotein particle ; SAGA ; Spt-Ada-Gcn5 acetyltransferase ; ATAC ; Ada2a-containing complex ; ubH2B ; monoubiquitinated histone H2B ; MudPIT ; multidimensional protein identification technology ; dNSAF ; distributive normalized spectral abundance factor ; HAT ; histone acetyltransferase ; RNAse ; ribonuclease ; DBD ; DNA-binding domain ; AD ; activating domain ; MMS1 ; methyl methanesulfonate ; GFP ; green fluorescent protein ; H3K9ac ; acetylated histone H3 Lysine 9 ; qRT-PCR ; quantitative

刊名：Journal of Molecular Biology

出版年：2016

作者：Michael J. Pagliassotti^a ; ^{michael.pagliassotti@colostate.edu" class="auth_mail" title="E-mail the corresponding author} ; Paul Y. Kim^b ; Andrea L. Estrada^a ; Claire M. Stewart^a ; Christopher L. Gentile^a

关键词：ATF4 ; activating transcription factor-4 ; ATF6α ; activating transcription factor-6α ; EB1 ; end binding protein-1 ; EDEM ; ER degradation-enhancing α-like protein ; ER ; endoplasmic reticulum ; ERAD ; ER-associated degradation ; GCN2 ; general control non-derepressible 2 kinase ; GRP78 ; glucose-regulated protein 78/immunoglobulin-heavy-chain-binding protein ; HRI ; heme-regulated inhibitor kinase ; IP3R1 ; inositol 14 ; 5-triphosphate receptor ; IRE1α ; inositol-requiring 1α ; MAM ; mitochondria-associated ER membra

刊名：Metabolism

出版年：2016

作者：Edward R. Horton¹ ; Pablo Astudillo¹ ; Martin J. Humphries ; ^{martin.humphries@manchester.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Jonathan D. Humphries

关键词：ECM ; extracellular matrix ; FAK ; focal adhesion kinase ; FN ; fibronectin ; GAP ; GTPase activating protein ; GEF ; guanine nucleotide exchange factor ; GTPase ; guanosine triphosphatase ; IAC ; integrin-associated adhesion complex ; ILK ; integrin-linked kinase ; IPP ; ILK-PINCH-Parvin complex ; IQGAP1 ; IQ motif&ndash ; containing GTPase&ndash ; activating protein 1 ; LIM ; Lin-11 ; Isl1 ; and Mec-3 ; MS ; mass spectrometry ; PINCH ; particularly interesting new cys-his protein 1 ; SYNCRIP ; synaptotagmin binding ; cytoplasm

刊名：Experimental Cell Research

出版年：2016

作者：Yusuke Ohba ; ^{yohba@med.hokudai.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Yoichiro Fujioka

关键词：BAPTA-AM ; acetoxymethyl ester of 1 ; 2-bis(2-aminophenoxy)ethane-NN ; N&prime ; N&prime ; -tetraacetic acid ; BiFC ; bimolecular fluorescence complementation ; CML ; chronic myeloid leukemia ; CFP ; cyan-emitting mutant of green fluorescent protein ; FRET ; Fö ; rster resonance energy transfer ; GAP ; GTPase activating protein ; GEF ; guanine nucleotide exchange factor ; GFP ; green fluorescent protein ; IM ; imatinib ; IP3 ; inositol 14 ; 5-triphosphate ; MDC ; monodansylcadaverine ; PI3K ; phosphoinositide 3-kinase ; PI(

刊名：Journal of Oral Biosciences

出版年：2016

作者：Cynthia Brisac¹ ; Shadi Salloum¹ ; Victor Yang¹ ; Esperance A.K. Schaefer¹ ; Jacinta A. Holmes¹ ; Stephane Chevaliez¹ ; ² ; Jian Hong¹ ; Charlie Carlton-Smith¹ ; Nadia Alatrakchi¹ ; Annie Kruger¹ ; Wenyu Lin¹ ; Raymond T. Chung¹ ; ^{rtchung@partners.org" class="auth_mail" title="E-mail the corresponding author}

关键词：GST ; glutathione S-transferase ; HAT ; histone acetyl transferase ; HCC ; hepatocellular carcinoma ; HCV ; hepatitis C virus ; IEG ; interferon effector gene ; IFN ; interferon ; IFNAR ; interferon-alpha receptor ; IQGAP ; IQ-motif containing GTPase activating protein ; IRF ; interferon regulatory factor ; ISG ; interferon-stimulated gene ; ISRE ; interferon-sensitive responsive element ; JAK ; janus kinase ; NF-κB ; nuclear factor κB ; PRR ; pattern recognition receptor ; STAT ; signal transducer and activator of transcri

刊名：Journal of Hepatology

出版年：2016