搜索页_ 7H-Pyrrolo[2

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在“Elsevier电子期刊”中，命中：32条，耗时：小于0.01 秒

在所有数据库中总计命中：188条

1.Bicyclic cytarabine analogues: synthesis and investigation of antitumor properties of novel, 6-aryl- and 6-alkyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one arabinosides

作者：Adam Mieczkowski^a ; ^{amiecz@ibb.waw.pl" class="auth_mail" title="E-mail the corresponding author} ; Malgorzata Makowska^a ; Justyna Sekula^a ; Ewelina Tomczyk^a ; Ewa Zalewska^a ; Anna Nasulewicz-Goldeman^b ; Joanna Wietrzyk^b

关键词：Bicyclic pyrimidine nucleoside analogues (BCNAs) ; Arabinonucleosides ; Cytarabine analogues ; Cytotoxicity

刊名：Tetrahedron

出版年：2015

2.In vitro baselining of new pyrrolopyrimidine EGFR-TK inhibitors with Erlotinib

作者：Eirik Sundby^a ; ^{Eirik.Sundby@hist.no" class="auth_mail" title="E-mail the corresponding author} ; Jin Han^a ; ^b ; ^{Jin.han@chem.ntnu.no" class="auth_mail" title="E-mail the corresponding author} ; Svein Jacob Kaspersen^b ; ¹ ; ^{Svein.jacob.kaspersen@chem.ntnu.no" class="auth_mail" title="E-mail the corresponding author} ; Bå ; rd Helge Hoff^b ; ^{bard.helge.hoff@chem.ntnu.no" class="auth_mail" title="E-mail the corresponding author}

关键词：Erlotinib (PubChem CID ; 176870) ; Dasatinib (PubChem CID ; 3062316) ; Lapatinib (PubChem CID ; 208908) ; 2-[[6-[4-(Hydroxymethyl)-2-methoxyphenyl]-7H-pyrrolo[2 ; 3-d]pyrimidin-4-yl]amino]-2-phenylethanol (PubChem CID ; 90466098)

刊名：European Journal of Pharmaceutical Sciences

出版年：2015

3.Identification of new 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4-amines as highly potent EGFR-TK inhibitors with Src-family activity

关键词：Pyrrolopyrimidine ; EGFR-TK ; Src-kinase ; Cancer ; CSF1R kinase ; Erlotinib

刊名：European Journal of Pharmaceutical Sciences

出版年：1 August 2014

4.Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors

作者：XianYun Jiao ; David J. Kopecky ; JinSong Liu ; JinQian Liu ; Juan C. Jaen ; Mario G. Cardozo ; Rajiv Sharma ; Nigel Walker ; Holger Wesche ; Shyun Li ; Ellyn Farrelly ; Shou-Hua Xiao ; Zhulun Wang ; Frank Kayser

关键词：ACK1 ; Cancer ; Tyrosine kinase inhibitor ; Furo[2 ; 3-d]-pyrimidin-4-amine ; 7H-Pyrrolo[2 ; 3-d]pyrimidin-4-amine

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

5.N²-Trimethylacetyl substituted and unsubstituted-N⁴-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines: Design, cellular receptor tyrosine kinase inhibitory activities and in vivo evaluation as antiang

作者：Aleem Gangjee^a ; ^{gangjee@duq.edu} ; Ojas A. Namjoshi^a ; Jianming Yu^a ; Michael A. Ihnat^b ; Jessica E. Thorpe^b ; Lora C. Bailey-Downs^b

关键词：RTK ; receptor tyrosine kinase ; EGFR ; epithelial growth factor receptor ; VEGFR ; vascular endothelial growth factor receptor ; PDGFR ; platelate derived growth factor receptor ; CAM ; chorioallantoic membrane ; Abl ; abelson tyrosine kinase ; CML ; chronic myelogen

刊名：Bioorganic and Medicinal Chemistry

出版年：2013

6.Synthesis of 5,7-disubstituted-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amines as microtubule inhibitors

作者：Aleem Gangjee^a ; ^{gangjee@duq.edu} ; Sonali Kurup^a ; ^&dagger ; ; Charles D. Smith^b

关键词：MT ; microtubule ; MDR ; multiple drug resistance ; Pgp ; P-glycoprotein ; MRP ; multidrug-resistance proteins ; TLC ; thin layer chromatography ; NMR ; nuclear magnetic resonance ; HRMS ; high resolution mass spectra

刊名：Bioorganic and Medicinal Chemistry

出版年：2013

7.N⁴-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors

作者：Aleem Gangjee^a ; ^{gangjee@duq.edu} ; Sonali Kurup^a ; Michael A. Ihnat^b ; Jessica E. Thorpe^b ; Bryan Disch^b

关键词：RTK ; receptor tyrosine kinase ; EGFR ; epidermal growth factor receptor ; VEGFR ; vascular endothelial growth factor receptor ; CSF-1 ; colony stimulating factor ; PDGFR ; platelet-derived growth factor receptors

刊名：Bioorganic and Medicinal Chemistry

出版年：2012

8.Synthesis and biological activity of N⁴-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents

作者：Aleem Gangjee ; Sonali Kurup ; Michael A Ihnat ; Jessica E. Thorpe ; Satyendra S. Shenoy

关键词：Pyrrolo[2 ; 3-d]pyrimidines ; Receptor tyrosine kinase inhibitors ; Antiangiogenic agents ; Antitumor agents

刊名：Bioorganic and Medicinal Chemistry

出版年：2010

9.Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors

作者：Jean-Yves Le Brazidec^a ; ^{jean@chempartner.com} ; Angela Pasis^a ; Betty Tam^a ; Christina Boykin^a ; Deping Wang^b ; Douglas J. Marcotte^b ; Gisela Claassen^a ; Jer-Hong Chong^a ; Jianhua Chao^a ; Junhua Fan^a ; Khanh Nguyen^a ; Laura Silvian^a ; ^b ; Leona Ling^b ; Lin Zhang^a ; Michael Choi^a ; Min Teng^a ; Nuzhat Pathan^a ; Shuo Zhao^a ; Tony Li^a ; Art Taveras^b

关键词：Aurora kinase ; Cyclin dependent kinase ; Cell cycle arrest ; Pyrrolopyrimidine ; Cytotoxicity

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

10.Novel inhibitors of epidermal growth factor receptor: (4-(Arylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanones and (1H-indol-2-yl)(4-(phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanones

作者：Thomas Beckers ; ^?/sup> ; Andreas Sellmer^a ; Emerich Eichhorn^a ; Herwig Pongratz^a ; Christoph Schä ; chtele^b ; ^&dagger ; ; Frank Totzke^b ; ^&dagger ; ; ^{f.totzke@proqinase.com} ; Gerhard Kelter^c ; ^&Dagger ; ; ^{gerhard.kelter@oncotest.de} ; Rebekka Krumbach^c ; ^&Dagger ; ; Heinz-Herbert Fiebig^c ; ^&Dagger ; ; Frank-D. Bö ; hmer^d ; ^§ ; ; ^{Boehmer@med.uni-jena.de} ; Siavosh Mahboobi^a ; ^{siavosh.mahboobi@chemie.uni-regensburg.de}

关键词：Tyrosine kinase inhibitor ; Anticancer agents ; Bisindolylmethanone ; Quinazoline ; Epidermal growth factor receptor (EGFR)

刊名：Bioorganic and Medicinal Chemistry

出版年：2012

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