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在“Elsevier电子期刊”中，命中：388条，耗时：0.0120241 秒

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1.The matrikine N-acetylated proline-glycine-proline induces premature senescence of nucleus pulposus cells via CXCR1-dependent ROS accumulation and DNA damage and reinforces the destructive effect of these cells on homeostasis of intervertebral discs

作者：Chencheng Feng¹ ; ^{doctorfgy@163.com} ; Yang Zhang¹ ; ^{65210796@qq.com} ; Minghui Yang¹ ; ^{doc_ymh@163.com} ; Minghong Lan¹ ; ^{fccdoc@me.com} ; Huan Liu¹ ; ^{20016040@163.com} ; Jian Wang¹ ; ^{tonywjxq@aliyun.com} ; Yue Zhou ; ¹ ; ^{happyzhou@vip.163.com} ; Bo Huang ; ¹ ; ^{fmmuhb@126.com}

关键词：IVD ; intervertebral disc ; IDD ; intervertebral disc degeneration ; SASP ; senescence-associated secreted phenotype ; NP ; nucleus pulposus ; AF ; annulus fibrosus ; SA-β-Gal ; senescence-associated β-galactosidase ; ECM ; extracellular matrix ; DDR ; DNA damage response ; N-Ac-PGP ; N-acetylated proline-glycine-proline ; RS ; replicative senescence ; Rb ; retinoblastoma protein ; RPX ; Reparixin ; ADAMTS ; a disintegrin and metalloproteinase with thrombospondin motifs ; MMP ; matrix metalloproteinase ; PE ; prolyl endopep

刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

出版年：2017

2.Down-Regulation of CD62L Shedding in T Cells by CD39⁺ Regulatory T Cells Leads to Defective Sensitization in Contact Hypersensitivity Reactions

作者：Karsten Mahnke¹ ; ⁶ ; ^{karsten.mahnke@med.uni-heidelberg.de} ; Jurgina Useliene¹ ; ² ; ⁶ ; Sabine Ring¹ ; ⁶ ; Paula Kage¹ ; Verena Jendrossek³ ; Simon C. Robson⁴ ; Matilda Bylaite-Bucinskiene² ; Kerstin Steinbrink⁵ ; Alexander H. Enk¹

关键词：ATP ; adenosine triphosphate ; CHS ; contact hypersensitivity ; DC ; dendritic cell ; LN ; lymph node ; TNBS ; 24 ; 6-trinitrobenzenesulfonic acid solution ; TNCB ; 24 ; 6-trinitrochlorobenzene ; Treg ; regulatory T cell ; WT ; wild type

刊名：Journal of Investigative Dermatology

出版年：2017

3.Regulatory Analysis of Effects of Hepatitis C Virus NS5A Polymorphisms on Efficacy of Elbasvir and Grazoprevir

作者：Takashi E. Komatsu¹ ; ^{takashi.komatsu@fda.hhs.gov} ; Sarita Boyd¹ ; Adam Sherwat¹ ; LaRee Tracy² ; Lisa K. Naeger¹ ; Julian J. O&rsquo ; Rear¹ ; Patrick R. Harrington¹ ; ^{patrick.harrington@fda.hhs.gov}

关键词：DAA ; Replication ; FDA ; Post-Hoc Analysis

刊名：Gastroenterology

出版年：2017

4.Activity-Dependent Exocytosis of Lysosomes Regulates the Structural Plasticity of Dendritic Spines

作者：Zahid Padamsey¹ ; Lindsay McGuinness¹ ; Scott J. Bardo¹ ; Marcia Reinhart¹ ; Rudi Tong¹ ; Anne Hedegaard¹ ; Michael L. Hart¹ ; Nigel J. Emptage¹ ; ² ; ^{nigel.emptage@pharm.ox.ac.uk}

关键词：lysosome ; calcium ; synaptic plasticity ; structural plasticity ; long-term potentiation ; MMP-9 ; TIMP-1 ; back-propagating action potentials ; dendritic spines ; hippocampus

刊名：Neuron

出版年：2017

5.The role of human leukocyte antigen DRB1-DQB1 haplotypes in the susceptibility to acquired idiopathic thrombotic thrombocytopenic purpura

作者：Gyö ; rgy Sinkovits^a ; ^{gysinkovits@gmail.com} ; Á ; gnes Szilá ; gyi^a ; Pé ; ter Farkas^a ; Dó ; ra Inotai^b ; Anikó ; Szilvá ; si^b ; Attila Tordai^c ; Katalin Rá ; zsó ; ^d ; Marienn Ré ; ti^e ; Zoltá ; n Prohá ; szka^a

关键词：Thrombotic thrombocytopenic purpura ; HLA-DRB1-DQB1 haplotypes ; PTPN22 c.1858C> ; T polymorphism ; Gender

刊名：Human Immunology

出版年：2017

6.Mutation G1629E Increases von Willebrand Factor Cleavage via a Cooperative Destabilization Mechanism

作者：Camilo Aponte-Santamarí ; a¹ ; ² ; ^{camilo.aponte@h-its.org} ; Svenja Lippok³ ; Judith J. Mittag³ ; Tobias Obser⁴ ; Reinhard Schneppenheim⁴ ; Carsten Baldauf⁵ ; Frauke Grä ; ter¹ ; ² ; Ulrich Budde⁶ ; Joachim O. Rä ; dler³

刊名：Biophysical Journal

出版年：2017

7.Degradation of two novel congenital TTP ADAMTS13 mutants by the cell proteasome prevents ADAMTS13 secretion

作者：Mary Underwood^a ; ^b ; ¹ ; ^{m.underwood@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Flora Peyvandi^a ; ^b ; ^c ; Isabella Garagiola^c ; Samuel Machin^a ; Ian Mackie^a

关键词：ADAMTS13 ; Von Willebrand factor-cleaving protease ; Thrombotic thrombocytopenic purpura ; Mutation ; Congenital ; Proteasome

刊名：Thrombosis Research

出版年：2016

8.von Willebrand Factor, ADAMTS13 Activity, and Decline in Kidney Function: A Population-Based Cohort Study

作者：Sanaz Sedaghat ; PhD¹ ; ^&lowast ; ; Paul S. de Vries ; MSc¹ ; ^&lowast ; ; Johan Boender ; MD² ; Michelle A.H. Sonneveld ; PhD² ; ³ ; Ewout J. Hoorn ; MD ; PhD⁴ ; Albert Hofman ; MD ; PhD¹ ; Moniek P.M. de Maat ; PhD² ; Oscar H. Franco ; MD ; PhD¹ ; M. Arfan Ikram ; MD ; PhD¹ ; ³ ; ⁵ ; Frank W.G. Leebeek ; MD ; PhD² ; Abbas Dehghan ; MD ; PhD¹ ; ^{a.dehghan@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author}

关键词：von Willebrand factor (vWF) ; ADAMTS13 activity ; von Willebrand factor protease ; kidney disease ; disease progression ; estimated glomerular filtration rate (eGFR) ; eGFR trajectory ; prothrombotic factors

刊名：American Journal of Kidney Diseases

出版年：2016

9.Intra- and intersubunit changes accompanying thermal activation of the HtrA2(Omi) protease homotrimer

作者：Miroslaw Jarzab^a ; ¹ ; Tomasz Wenta^a ; ¹ ; Dorota Zurawa-Janicka^a ; Agnieszka Polit^b ; Artur J. Gieldon^c ; Magdalena Wysocka^c ; Przemyslaw Glaza^a ; Joanna Skorko-Glonek^a ; Jerzy Ciarkowski^c ; Adam Lesner^c ; Barbara Lipinska^a ; ^{barbara.lipinska@biol.ug.edu.pl" class="auth_mail" title="E-mail the corresponding author}

关键词：PD ; protease domain ; PD* ; protease domain of the neighboring subunit ; PDZ domain ; domain with homology to postsynaptic density of 95 ; kDa ; disc large and zonula occludens 1 proteins ; Fw ; fluorescence intensity of a labeled protein with tryptophan residue ; F0 ; fluorescence intensity of a labeled protein without tryptophan residue ; τw ; fluorescence lifetime of a labeled protein with tryptophan residue ; τ0 ; fluorescence lifetime of a labeled protein without tryptophan residue ; mBBr ; monobromobi

刊名：Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

出版年：2016

10.Systematic evaluation of methyl ester bioisosteres in the context of developing alkenyldiarylmethanes (ADAMs) as non-nucleoside reverse transcriptase inhibitors (NNRTIs) for anti-HIV-1 chemotherapy

作者：Ayako Hoshi^a ; Takeshi Sakamoto^a ; ^{sakamoto@josai.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Jun Takayama^a ; Meiyan Xuan^a ; Mari Okazaki^a ; Tracy L. Hartman^b ; Robert W. Buckheit Jr.^b ; Christophe Pannecouque^c ; Mark Cushman^d ; ^{cushman@purdue.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：ADAM ; alkenyldiarylmethane ; NNRTI ; non-nucleoside reverse transcriptase inhibitor ; RT ; reverse transcriptase ; HIV-1 ; human immunodeficiency virus type 1 ; AIDS ; acquired immune deficiency syndrome ; ART ; antiretroviral therapy ; NRTI ; nucleoside reverse transcriptase inhibitor ; PI ; protease inhibitor ; INI ; integrase inhibitors ; FI ; fusion inhibitor ; CCR5I ; CC chemokine receptor inhibitor ; dNTPs ; deoxynucleoside triphosphate ; AZT ; azidothymidine (zidovudine) ; EDCI ; 1-(3-dimethylaminopropyl)-3-ethylc

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

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