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在“Elsevier电子期刊”中，命中：110条，耗时：0.0249893 秒

在所有数据库中总计命中：1,264条

1.Macrocyclic MEK1/2 inhibitor with efficacy in a mouse model of cardiomyopathy caused by lamin A/C gene mutation

作者：Wei Wu^a ; ^b ; Mahendra D. Chordia^c ; ^g ; Barry P. Hart^d ; E. Sathyajith Kumarasinghe^c ; Min K. Ji^c ; Ajay Bhargava^e ; Michael W. Lawlor^f ; Ji-Yeon Shin^a ; ^b ; Fusako Sera^a ; Shunichi Homma^a ; Antoine Muchir^a ; ^b ; ^h ; Uday R. Khire^c ; ^d ; ^{ukhire@allomek.com} ; Howard J. Worman^a ; ^b ; ^{hjw14@columbia.edu}

关键词：Cardiomyopathy ; Emery-Dreifuss muscular dystrophy ; Extracellular signal-regulated kinase ; Lamin ; MEK inhibitor ; Mitogen-activated protein kinase

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

2.Identification of natural allosteric inhibitor for Akt1 protein through computational approaches and in vitro evaluation

作者：T. Pragna Lakshmi^a ; ^{pragnapcu@gmail.com} ; Amit Kumar^a ; ^{amit.kumar10nov@gmail.com} ; Veena Vijaykumar^b ; ^{btveenavijaykumar@gmail.com} ; Sakthivel Natarajan^b ; ^{puns2005@gmail.com} ; Ramadas Krishna^a ; ^{krishstrucbio@gmail.com}

关键词：PKB ; protein kinase B ; CPH ; common pharmacophore hypothesis ; RMSE ; root mean-square error ; PLS ; partial least-squares ; QSAR ; quantitative structure-activity relationship ; TCM ; traditional Chinese medicine ; HTVS ; high-throughput virtual screening ; SP ; standard precision ; XP ; extra precision ; DFT ; density functional theory ; HOMO ; higher occupied frontier orbitals ; LUMO ; lower unoccupied frontier orbitals ; MDS ; molecular dynamic simulations

刊名：International Journal of Biological Macromolecules

出版年：2017

3.Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design

作者：Michelle S. Miller^a ; Sweta Maheshwari^b ; Fiona M. McRobb^c ; Kenneth W. Kinzler^d ; L. Mario Amzel^b ; Bert Vogelstein^d ; Sandra B. Gabelli^a ; ^b ; ^e ; ^{gabelli@jhmi.edu}

关键词：PIK3CA ; PI3K ; PIP2 ; PIP3 ; Fragment-based drug discovery

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

4.The GABA_B positive allosteric modulators CGP7930 and GS39783 stimulate ERK1/2 signalling in cells lacking functional GABA_B receptors

作者：Maria C. Olianas ; ^{molianas@unica.it} ; Simona Dedoni ; Pierluigi Onali

关键词：CGP7930 (PubChem CID ; 5024764) ; GS39783 (PubChem CID ; 6604928) ; (-)-baclofen (PubChem CID ; 44602) ; SKF97541 (PubChem CID ; 5230) ; CGP55845 (PubChem CID ; 5311042) ; CGP54626 (PubChem CID ; 197584) ; phorbol 12-myristate 13 acetate (PubChem CID ; 27924) ; Go 6850 (PubChem CID ; 2396) ; 5Z-7-oxozeaenol (PubChem CID ; 9863776) ; GW5074 (PubChem CID ; 5924208)

刊名：European Journal of Pharmacology

出版年：2017

5.Kinetic modelling of in vitro data of PI3K, mTOR1, PTEN enzymes and on-target inhibitors Rapamycin, BEZ235, and LY294002

作者：Alexey Goltsov^a ; ^{a.goltsov@abertay.ac.uk} ; Ghassan Tashkandi^b ; ^{s1163633@exseed.ed.ac.uk} ; Simon P. Langdon^b ; ^{Simon.Langdon@ed.ac.uk} ; David J. Harrison^c ; ^{David.Harrison@st-andrews.ac.uk} ; James L. Bown^a ; ^d ; ^{j.bown@abertay.ac.uk}

关键词：Kinetic modelling ; PI3K ; mTOR1 ; PTEN ; Rapamycin ; BEZ235

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

6.Identification and characterization of potent, selective and metabolically stable IKKβ inhibitor

作者：Doyeon Kim ; Yun Gyeong Kim ; Jae Hong Seo ; Kye Jung Shin ; ^{kyejung@catholic.ac.kr" class="auth_mail" title="E-mail the corresponding author}

关键词：IKKβ inhibitor ; NF-κB ; Reumatoid arthritis ; Allosteric inhibitor

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

7.DF2755A, a novel non-competitive allosteric inhibitor of CXCR1/2, reduces inflammatory and post-operative pain

作者：Alexandre H. Lopes^a ; ^d ; Laura Brandolini^b ; ^d ; Andrea Aramini^b ; ^d ; Gianluca Bianchini^b ; ^d ; Rangel L. Silva^a ; ^d ; Ana C. Zaperlon^c ; ^d ; Waldiceu A. Verri Jr.^c ; ^d ; José ; C. Alves-Filho^a ; ^d ; Fernando Q. Cunha^a ; ^d ; Mauro M. Teixeira^c ; ^d ; Marcello Allegretti^b ; ^d ; ^{marcello.allegretti@dompe.it" class="auth_mail" title="E-mail the corresponding author} ; Thiago M. Cunha^a ; ^d ; ^{thicunha@fmrp.usp.br" class="auth_mail" title="E-mail the corresponding author}

关键词：CXCR1/2 ; chemokine (C-X-C motif) receptor 1/2 ; LPS ; lipopolysaccharide ; CFA ; complete freund&rsquo ; s adjuvant ; CXCL8 ; chemokine (C-X-C motif) ligand 8 ; CNS ; central nervous system ; PMN ; polymorphonuclear cell family ; HBSS ; Hanks&rsquo ; balanced salt solution ; PGE2 ; prostaglandin E2 ; TRPV1 ; transient receptor potential cation channel subfamily V member 1 ; CGRP ; calcitonin gene related peptide ; ERK ; extracellular-signal-regulated kinases ; NMDA ; N-methyl-D-aspartate

刊名：Pharmacological Research

出版年：2016

8.Identification of allosteric ERK2 inhibitors through in silico biased screening and competitive binding assay

作者：Takayoshi Kinoshita^a ; ^{kinotk@b.s.osakafu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Hajime Sugiyama^b ; Yurika Mori^a ; Naruhide Takahashi^a ; Atsushi Tomonaga^b

关键词：ERK2 ; extra-cellular signal-regulated kinase 2 ; STAT3 ; hepatic signal transducer and activator of transcription 3 ; 5-IOD ; 5&prime ; -iodotubercidin ; PEP ; designed peptide inhibitor ; pNA ; p-nitroaniline

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

9.Discovery of 3-benzyl-1,3-benzoxazine-2,4-dione analogues as allosteric mitogen-activated kinase kinase (MEK) inhibitors and anti-enterovirus 71 (EV71) agents

作者：Jing Sun^a ; Yan Niu^a ; ^{yanniu@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Chao Wang^a ; Hao Zhang^b ; Bingyu Xie^b ; Fengrong Xu^a ; Hongwei Jin^c ; Yihong Peng^b ; Lei Liang^a ; Ping Xu^a ; ^{pingxu@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：3-Benzyl-1 ; 3-benzoxazine-2 ; 4-dione ; MEK inhibitor ; EV71 ; Antiviral agent

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

10.Hemiasterlin derivative (R)(S)(S)-BF65 and Akt inhibitor MK-2206 synergistically inhibit SKOV3 ovarian cancer cell growth

关键词：Hemiasterlin derivative (R)(S)(S)-BF65 ; Akt inhibitor MK-2206 ; MAPK and Akt signaling pathways ; Ovarian cancer

刊名：Biochemical Pharmacology

出版年：2016

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