搜索页_ Aurash Shahripoura

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在“Elsevier电子期刊”中，命中：7条，耗时：小于0.01 秒

在所有数据库中总计命中：1条

1.Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold

作者：Yuping Zhu^a ; ^{yuping_zhu@merck.com" class="auth_mail" title="E-mail the corresponding author} ; Reynalda K. de Jesus^a ; Haifeng Tang^a ; Shawn P. Walsh^a ; Jinlong Jiang^a ; Xin Gu^a ; Nardos Teumelsan^a ; Aurash Shahripour^a ; Barbara Pio^a ; Fa-Xiang Ding^a ; Sookhee Ha^a ; Birgit T. Priest^b ; Andrew M. Swensen^b ; Magdalena Alonso-Galicia^b ; John P. Felix^b ; Richard M. Brochu^b ; Timothy Bailey^b ; Brande Thomas-Fowlkes^b ; Xiaoyan Zhou^c ; Lee-Yuh Pai^c ; Caryn Hampton^c ; Melba Hernandez^c ; Karen Owens^d ; Juliann Ehrhart^e ; Sophie Roy^c ; Gregory J. Kaczorowski^b ; Lihu Yang^a ; Emma R. Parmee^a ; Kathleen Sullivan^b ; Maria L. Garcia^b ; Alexander Pasternak^a

关键词：hERG ; ROMK ; Hypertension ; Heart failure ; Diuresis ; Natriuresis

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

2.Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation

作者：Shawn P. Walsh^a ; ^{shawn_walsh@merck.com" class="auth_mail" title="E-mail the corresponding author} ; Aurash Shahripour^a ; Haifeng Tang^a ; Reynalda K. de Jesus^a ; Nardos Teumelsan^a ; Yuping Zhu^a ; Jessica Frie^a ; Birgit T. Priest^b ; Andrew M. Swensen^b ; Magdalena Alonso-Galicia^b ; John P. Felix^b ; Richard M. Brochu^b ; Timothy Bailey^b ; Brande Thomas-Fowlkes^b ; Xiaoyan Zhou^c ; Lee-Yuh Pai^c ; Caryn Hampton^c ; Melba Hernandez^c ; Karen Owens^d ; Juliann Ehrhart^e ; Sophie Roy^c ; Gregory J. Kaczorowski^b ; Lihu Yang^a ; Maria L. Garcia^b ; Alexander Pasternak^a

关键词：hERG ; ROMK ; Hypertension ; Heart failure ; Diuresis ; Natriuresis

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

3.Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, Part I: Transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors

作者：Mark S. Plummer^a ; ^{marksplummer@gmail.com} ; Joseph Cornicelli^b ; Howard Roark^a ; Donald J. Skalitzky^a ; Charles J. Stankovic^d ; Susan Bove^b ; Jayvardhan Pandit^c ; Annise Goodman^a ; James Hicks^a ; Aurash Shahripour^a ; David Beidler^b ; Xiao Kang Lu^b ; Brian Sanchez^b ; Christopher Whitehead^a ; Ron Sarver^e ; Timothy Braden^b ; Richard Gowan^b ; Xi Qiang Shen^b ; Katherine Welch^b ; Adam Ogden^d ; Nalini Sadagopan^d ; Heidi Baum^d ; Howard Miller^d ; Craig Banotai^e ; Cindy Spessard^e ; Sandra Lightle^e

关键词：Phosphodiesterase 2 (PDE2)inhibition ; Structure-based drug design ; Osteoarthritis(OA)pain

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2013

4.Discovery of potent selective bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model. Part II: Optimization studies and demonstration of in vivo efficacy

关键词：Phosphodiesterase 2 (PDE2) inhibitors ; Structure based drug design ; Osteoarthritis (OA) pain

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2013

5.Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide

作者：Shahripour ; Aurash B. ; Plummer ; Mark S. ; Lunney ; Elizabeth A. ; Sawyer ; Tomi K. ; Stankovic ; Charles J. ; et. al.

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2001

6.Structure-based design of novel, dipeptide ligands targeting the pp60^Src SH2 domain

作者：Shahripour ; Aurash ; Para ; Kimberly S. ; Plummer ; Mark S. ; Lunney ; Elizabeth A. ; Holland ; Debra R. ; et. al.

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：1997

7.Novel phosphotyrosine mimetics in the design of peptide ligands for pp60^src SH2 domain

作者：Shahripour ; Aurash ; Plummer ; Mark S. ; Lunney ; Elizabeth A. ; Para ; Kimberly S. ; Stankovic ; Charles J. ; et. al.

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：1996

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2000年及以前(2)

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