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在“Elsevier电子期刊”中，命中：155条，耗时：0.0120011 秒

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1.Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase

作者：Idris Raji^a ; Fatima Yadudu^a ; Emily Janeira^e ; Shaghayegh Fathi^a ; Lindsey Szymczak^c ; James Richard Kornacki^c ; Kensei Komatsu^d ; Jian-Dong Li^d ; Milan Mrksich^c ; Adegboyega K. Oyelere^a ; ^b ; ^{aoyelere@gatech.edu}

关键词：HDAC ; histone deacetylase ; HDACi ; histone deacetylase inhibitors ; COX ; cyclooxygenases ; NSAIDs ; non-steroidal anti-inflammatory drugs ; AR ; androgen receptor ; ZBG ; zinc binding group ; PGE2 ; prostaglandin E2

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

2.Perturbation of genome integrity to fight pathogenic microorganisms

作者：Kinga Nyí ; ri ; ^{nyiri.kinga@ttk.mta.hu} ; Beá ; ta G. Vé ; rtessy ; ^{vertessy@mail.bme.hu}

关键词：CH2THF ; 5 ; 10-methylene tetrahydrofolate ; DCD ; dCTP deaminase ; DCD-DUT ; bifunctional dCTP deaminase&ndash ; dUTPase ; DUT ; dUTPase ; DHF ; dihydrofolate ; DHFR ; dihydrofolate reductase ; DHFR&ndash ; TS ; bifunctional dihydrofolate reductase &ndash ; thymidylate synthase ; FAD ; flavin adenine dinucleotide ; SHMT ; serine hydroxymethyltransferase ; THF ; tetrahydrofolate ; TK ; thymidine kinase ; TS ; ThyX ; classical and flavin-dependent thymidylate synthase ; TMPK ; dTMP kinase ; Ugi ; uracil-DNA glycosylase inhibitor

刊名：Biochimica et Biophysica Acta (BBA) - General Subjects

出版年：2017

3.In silico identification of putative bifunctional Plk1 inhibitors by integrative virtual screening and structural dynamics approach

作者：Shagufta Shafique ; Nousheen Bibi ; Sajid Rashid ; ^{sajidrwp@yahoo.co.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：Plk1 ; Bifunctional inhibitors ; Structure based virtual screening ; Molecular dynamics simulation ; Pharmacophore

刊名：Journal of Theoretical Biology

出版年：2016

4.Thermodynamic properties of leukotriene A₄ hydrolase inhibitors

关键词：LTA4H ; leukotriene A4 hydrolase ; LTA4 ; leukotriene A4 ; LTB4 ; leukotriene B4 ; kDa ; kilo Dalton ; PGP ; prolin&ndash ; glycin&ndash ; prolin ; TSA ; thermal shift assay ; TM ; melting point ; ITC ; isothermal titration calorimetry ; DSF ; different scanning fluorimetry ; Ki ; inhibitory constant ; Kd ; dissoziation constant

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

5.A potent bidirectional promoter from the monocot cereal Eleusine coracana

作者：Saswati Sen ; ^{sensaswati04@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Samir Kr. Dutta

关键词：Bidirectional promoter ; Cis-regulatory elements ; Dual reporter vector construct ; Finger millet ; Ragi bifunctional inhibitor (RBI) ; Ragi trypsin inhibitor (RTI) ; Reporter gene expression ; Transient plant transformation

刊名：Phytochemistry

出版年：2016

6.Structures of a bi-functional Kunitz-type STI family inhibitor of serine and aspartic proteases: Could the aspartic protease inhibition have evolved from a canonical serine protease-binding loop?

作者：Yasel Guerra^a ; ^{yaselg@ibt.unam.mx" class="auth_mail" title="E-mail the corresponding author} ; Pedro A. Valiente^b ; Tirso Pons^c ; Colin Berry^d ; Enrique Rudiñ ; o-Piñ ; era^a ; ^{rudino@ibt.unam.mx" class="auth_mail" title="E-mail the corresponding author}

关键词：BASI ; barley alpha-amylase/subtilisin inhibitor ; EcTI ; Enterolobium contortisiliquum trypsin inhibitor ; PSPI ; potato serine protease inhibitor ; API-A ; arrowhead proteinase inhibitor A ; PDI ; potato cathepsin D inhibitor ; STI ; soybean trypsin inhibitor ; SLAPI ; Solanum lycopersicum aspartic protease inhibitor ; TKI ; Tamarind Kunitz-type inhibitor

刊名：Journal of Structural Biology

出版年：2016

7.Targeting the Type Three Secretion System in Pseudomonas aeruginosa

作者：Ahalieyah Anantharajah¹ ; Marie-Paule Mingeot-Leclercq¹ ; Franç ; oise Van Bambeke¹ ; ^{francoise.vanbambeke@uclouvain.be" class="auth_mail" title="E-mail the corresponding author}

关键词：type three secretion system ; Pseudomonas aeruginosa ; toxins ; cytotoxicity ; inflammasome activation ; virulence.

刊名：Trends in Pharmacological Sciences

出版年：2016

8.UDP-GlcNAc pathway: Potential target for inhibitor discovery against M. tuberculosis

作者：Chitra Rani ; Inshad Ali Khan ; ^{iakhan@iiim.res.in" class="auth_mail" title="E-mail the corresponding author} ; ^{inshad@rediffmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Drug resistance ; GlmU ; M. tuberculosis ; Peptidoglycan ; Target based screening ; UDP-GlcNAc

刊名：European Journal of Pharmaceutical Sciences

出版年：2016

9.High-throughput screen identifies small molecule inhibitors targeting acetyltransferase activity of Mycobacterium tuberculosis GlmU

作者：Chitra Rani^a ; ^d ; Rukmankesh Mehra^b ; Rashmi Sharma^a ; ^d ; Reena Chib^a ; ^d ; Priya Wazir^c ; Amit Nargotra^b ; ^d ; ^{anargotra@iiim.ac.in" class="auth_mail" title="E-mail the corresponding author} ; Inshad Ali Khan^a ; ^d ; ^{iakhan@iiim.res.in" class="auth_mail" title="E-mail the corresponding author} ; ^{inshad@rediffmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：UDP-GlcNAc ; M. tuberculosis ; GlmU ; Rifampicin ; Acetyltransferase ; Drug resistant

刊名：Tuberculosis

出版年：2015

10.Investigation of fluorinated and bifunctionalized 3-phenylchroman-4-one (isoflavanone) aromatase inhibitors

作者：Erica Amato ; Tony Bankemper ; Rebecca Kidney ; Thuy Do ; Alma Onate ; Fathima Shazna Thowfeik ; Edward J. Merino ; Stefan Paula ; Lili Ma

关键词：Arg 115 ; arginine 115 ; Ile 133 ; isoleucine 133 ; Phe 221 ; phenylalanine 221 ; Trp 224 ; tryptophan 224 ; Asp 309 ; aspartic acid 309 ; Thr 310 ; threonine 310 ; Val 370 ; valine 370 ; Leu 477 ; leucine 477 ; CYP19 ; cytochrome P450 aromatase ; AIs ; aromatase inhibitors ; SERMs ; selective estrogen receptor modulators ; NSAIs ; non-steroidal aromatase inhibitors ; NMR ; nuclear magnetic resonance ; MS ; mass spectrometry ; HPLC ; high performance liquid chromatography

刊名：Bioorganic and Medicinal Chemistry

出版年：1 January, 2014

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