搜索页_+Bioisostere

常用资源

电子图书

期刊论文

学位会议

外文资源

特色专题

内部出版物

在“Elsevier电子期刊”中，命中：303条，耗时：小于0.01 秒

1.Novel methods for the synthesis of 1,5,2-diazaphosphinines as potential inhibitors of HCV polymerase

作者：Daniel Da Costa^a ; ^{daniel.da.costa@merck.com} ; Arlè ; ne Roland^b ; Cyril B. Dousson^a

关键词：Hepatitis C virus ; 15 ; 2-Diazaphosphinines ; NS5B non-nucleoside inhibitors ; Thiadiazine bioisostere ; Allosteric inhibitors

刊名：Tetrahedron Letters

出版年：2017

2.Squarate-based carbocyclic nucleosides: Syntheses, computational analyses and anticancer/antiviral evaluation

作者：Meijun Lu^a ; ^b ; Qing-Bin Lu^b ; John F. Honek^a ; ^{jhonek@uwaterloo.ca}

关键词：Squaric acid ; Carbocyclic ; Nucleoside ; Anticancer ; Antiviral ; Bioisostere

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

3.Benzenesulphonamide inhibitors of the cytolytic protein perforin

作者：Julie A. Spicer^a ; ^b ; ^{j.spicer@auckland.ac.nz} ; Christian K. Miller^a ; ^b ; Patrick D. O'Connor^a ; ^b ; Jiney Jose^a ; ^b ; Kristiina M. Huttunen^a ; ^c ; Jagdish K. Jaiswal^a ; ^b ; William A. Denny^a ; ^b ; Hedieh Akhlaghi^d ; Kylie A. Browne^d ; Joseph A. Trapani^d ; ^e

关键词：Perforin ; Perforin inhibitor ; Benzenesulphonamide ; Bioisostere ; Immunosuppressant

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

4.Discovery of new hit-molecules targeting Plasmodium falciparum through a global SAR study of the 4-substituted-2-trichloromethylquinazoline antiplasmodial scaffold

作者：Justine Desroches^a ; ¹ ; Charline Kieffer^a ; ¹ ; Nicolas Primas^a ; Sé ; bastien Hutter^b ; Armand Gellis^a ; Hussein El-Kashef^c ; Pascal Rathelot^a ; Pierre Verhaeghe^d ; ^{pierre.verhaeghe@univ-tlse3.fr} ; Nadine Azas^b ; Patrice Vanelle^a ; ^{patrice.vanelle@univ-amu.fr}

关键词：Quinazoline ; Quinoline ; Quinoxaline ; Thienopyrimidine ; Trichloromethyl goup ; Plasmodium falciparum ; In vitro antiplasmodial activity ; In vitro HepG2 cytotoxicity ; Structure-activity relationships

刊名：European Journal of Medicinal Chemistry

出版年：2017

5.Benzimidazolone bioisosteres of potent GluN2B selective NMDA receptor antagonists

作者：Ines Lü ; tnant^a ; Dirk Schepmann^a ; Bernhard Wü ; nsch^a ; ^b ; ^{wuensch@uni-muenster.de" class="auth_mail" title="E-mail the corresponding author}

关键词：NMDA antagonists ; GluN2B selective ; Benzimidazolone bioisosteres ; Tricyclic benzo[7]annulenamines ; Receptor selectivity

刊名：European Journal of Medicinal Chemistry

出版年：2016

6.LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates

作者：Arik A. Zur^a ; ^{riko.zur@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Huan-Chieh Chien^a ; Evan Augustyn^b ; Andrew Flint^b ; Nathan Heeren^b ; Karissa Finke^b ; Christopher Hernandez^b ; Logan Hansen^b ; Sydney Miller^b ; Lawrence Lin^a ; Kathleen M. Giacomini^a ; Claire Colas^c ; ^d ; Avner Schlessinger^c ; ^d ; Allen A. Thomas^b ; ^{thomasaa@unk.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：SLC7A5 ; Amino acid ; Acyl sulfonamide ; Tetrazole ; Transporter substrate ; Transporter inhibitor

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

7.Systematic evaluation of methyl ester bioisosteres in the context of developing alkenyldiarylmethanes (ADAMs) as non-nucleoside reverse transcriptase inhibitors (NNRTIs) for anti-HIV-1 chemotherapy

作者：Ayako Hoshi^a ; Takeshi Sakamoto^a ; ^{sakamoto@josai.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Jun Takayama^a ; Meiyan Xuan^a ; Mari Okazaki^a ; Tracy L. Hartman^b ; Robert W. Buckheit Jr.^b ; Christophe Pannecouque^c ; Mark Cushman^d ; ^{cushman@purdue.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：ADAM ; alkenyldiarylmethane ; NNRTI ; non-nucleoside reverse transcriptase inhibitor ; RT ; reverse transcriptase ; HIV-1 ; human immunodeficiency virus type 1 ; AIDS ; acquired immune deficiency syndrome ; ART ; antiretroviral therapy ; NRTI ; nucleoside reverse transcriptase inhibitor ; PI ; protease inhibitor ; INI ; integrase inhibitors ; FI ; fusion inhibitor ; CCR5I ; CC chemokine receptor inhibitor ; dNTPs ; deoxynucleoside triphosphate ; AZT ; azidothymidine (zidovudine) ; EDCI ; 1-(3-dimethylaminopropyl)-3-ethylc

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

8.Medicinal attributes of pyrazolo[1,5-a]pyrimidine based scaffold derivatives targeting kinases as anticancer agents

作者：Nasser S.M. Ismail^a ; ^b ; ^{saadnasser2003@yahoo.com} ; Ghada M.E. Ali^c ; Diaa A. Ibrahim^c ; Amira M. Elmetwali^c

关键词：Protein kinase ; Bioisostere ; Pyrazolo[1 ; 5-a]pyrimidine ; Anticancer

刊名：Future Journal of Pharmaceutical Sciences

出版年：2016

9.New peptide deformylase inhibitors design, synthesis and pharmacokinetic assessment

作者：Fengping Lv^a ; Chen Chen^a ; Yang Tang^a ; Jianhai Wei^a ; Tong Zhu^b ; ^{tongzhu@chem.ecnu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Wenhao Hu^a ; ^{whu@chem.ecnu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：PDF inhibitor ; Antibacterial drug ; Antibiotics resistance ; MRSA ; Docking study ; Amide bioisosteres

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

10.Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of replacement of the 3-hydroxyphenyl group with pyridine or thiophene bioisosteres

作者：Chad M. Kormos ; Moses G. Gichinga ; Scott P. Runyon ; James B. Thomas ; S. Wayne Mascarella ; Ann M. Decker ; Herná ; n A. Navarro ; F. Ivy Carroll ; ^{fic@rti.org" class="auth_mail" title="E-mail the corresponding author}

关键词：[35S]GTPγS ; sulfur-35 guanosine-5&prime ; -O-(3-thio)triphosphate ; DAMGO ; [D-Ala2 ; MePhe4 ; Gly-ol5]enkephalin ; DPDPE ; [D-Pen2 ; D-Pen5]enkephalin ; U69 ; 593 ; (5α ; 7α ; 8β)-(&minus ; )-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4 ; 5]dec-8-yl]benzeneacetamide

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

按检索点细分(303)

题名(96)

关键词(124)

文摘(204)

按出版年细分(303)

2027年及以后(6)

2017年(4)

2016年(21)

2015年(5)

2013年(23)

2012年(19)

2011年(21)

2010年(25)

2009年(14)

2008年(24)

2007年(18)

2006年(20)

2005年(9)

2004年(11)

2003年(11)

2002年(10)

2001年(13)

2000年(7)

2000年及以前(42)

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700