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在“Elsevier电子期刊”中，命中：11,719条，耗时：0.1069471 秒

在所有数据库中总计命中：130,789条

1.Synthesis, in vitro and in vivo biological evaluation of new oxysterols as modulators of the liver X receptors

作者：Ove Alexander Hø ; gmoen Å ; strand^a ; Elvar Ö ; rn Viktorsson^a ; Aleksander Lim Kristensen^a ; Dag Ekeberg^b ; Hanne Rø ; berg-Larsen^c ; Steven Ray Wilson^c ; Mari Gabrielsen^d ; Ingebrigt Sylte^d ; Arild Christian Rustan^e ; G. Hege Thoresen^e ; ^f ; På ; l Rongved^a ; Eili Tranheim Kase^e ; ^{e.t.kase@farmasi.uio.no}

关键词：Steroid synthesis ; Nuclear receptor modulation ; Molecular modelling ; Biological evaluation

刊名：The Journal of Steroid Biochemistry and Molecular Biology

出版年：2017

2.Synthesis, physicochemical and biological studies of technetium-99m labeled tacrine derivative as a diagnostic tool for evaluation of cholinesterase level

作者：Ewa Gniazdowska^a ; Przemysław Koźmiński^a ; ^{p.kozminski@ichtj.waw.pl} ; Marek Wasek^b ; Marek Bajda^c ; Joanna Sikora^d ; Elżbieta Mikiciuk-Olasik^e ; Paweł Szymański^f ; ^{pawel.szymanski@umed.lodz.pl}

关键词：Tac ; tacrine (123 ; 4-tetrahydroacridin-9-amine) ; AD ; Alzheimer&rsquo ; s disease ; AChE ; acetylcholinesterase ; CNS ; central nervous system ; IC50 ; half maximal inhibitory concentration ; BM ; biologically active molecule ; BFCA ; Bifunctional Coupling Agent ; NS3 ; tris(2-mercaptoethyl)-amine ; CN-BFCA ; isocyanobutyric acid succinimidyl ester ; n.c.a. ; no carrier added ; HPLC ; high-performance liquid chromatography ; RT ; retention time ; PBS ; phosphate buffered saline ; TFA ; trifluoroacetic acid ; RCP ; radioche

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

3.Synthesis and biological evaluation of chemical tools for the study of Dolichol Linked Oligosaccharide Diphosphatase (DLODP)

关键词：CDG ; Diphosphatase ; Phosphosugars ; Disubstituted diphosphates ; Biological evaluation ; Glycochemistry

刊名：European Journal of Medicinal Chemistry

出版年：2017

4.Design, facile synthesis and biological evaluations of novel pyrano[3,2-a]phenazine hybrid molecules as antitumor agents

作者：Yuanyuan Lu^a ; ^b ; Yuru Yan^a ; ^b ; Linlin Wang^a ; ^b ; Xiaobing Wang^a ; ^d ; Jing Gao^a ; ^b ; Tao Xi^a ; ^b ; Zhixiang Wang^a ; ^c ; Feng Jiang^a ; ^c ; ^{daniel_chem@126.com}

关键词：Pyrano[3 ; 2-a]phenazine ; Hybrid molecules ; Antiproliferative activity ; In vivo assay ; Topoisomerase dual inhibition ; Cell cycle arrest ; Apoptosis

刊名：European Journal of Medicinal Chemistry

出版年：2017

5.Design, synthesis and biological evaluation of regioisomers of 666-15 as inhibitors of CREB-mediated gene transcription

作者：Fuchun Xie^a ; ¹ ; Bingbing X. Li^a ; ¹ ; Xiangshu Xiao^a ; ^b ; ^c ; ^{xiaoxi@ohsu.edu}

关键词：CREB ; Cancer ; 666-15 ; Regioisomer ; Bioactive conformation

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

6.Synthesis and biological evaluation of a new class of benzothiazines as neuroprotective agents

作者：Alessandra Mancini^a ; Alessia Chelini^a ; Angela Di Capua^a ; ^b ; Loretta Castelli^c ; Simone Brogi^a ; Marco Paolino^a ; Germano Giuliani^a ; Andrea Cappelli^a ; Maria Frosini^d ; Lorenzo Ricci^d ; Erminia Leonelli^d ; Gianluca Giorgi^a ; Antonio Giordani^e ; Jacopo Magistretti^c ; Maurizio Anzini^a ; ^{maurizio.anzini@unisi.it}

关键词：Neuroprotective agents ; Neurodegenerative diseases ; Benzothiazine derivatives ; SH-SY5Y cells ; Neuronal voltage-dependent Na+ and Ca2+ currents

刊名：European Journal of Medicinal Chemistry

出版年：2017

7.Design, synthesis and biological activity evaluation of novel 2,6-difluorobenzamide derivatives through FtsZ inhibition

作者：Fangchao Bi^a ; ¹ ; Liwei Guo^a ; ¹ ; Yinhu Wang^a ; Henrietta Venter^b ; Susan J. Semple^b ; Fang Liu^a ; Shutao Ma^a ; ^{mashutao@sdu.edu.cn}

关键词：Benzamide derivatives ; Design and synthesis ; FtsZ inhibition ; Biological activity

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

8.Novel 2-arylazoimidazole derivatives as inhibitors of Trypanosoma cruzi proliferation: Synthesis and evaluation of their biological activity

作者：Alejandra Salerno^a ; Ana M. Celentano^b ; ^c ; Julieta Ló ; pez^a ; Virginia Lara^a ; Carlos Gaozza^a ; Darí ; o E. Balcazar^d ; Carolina Carrillo^d ; Fernanda M. Frank^b ; ^e ; Marí ; a M. Blanco^a ; ^{mblanco@ffyb.uba.ar}

关键词：2-Arylazoimidazoles ; Ultrasound-assisted alkylation ; Chagas' disease ; Biological activity

刊名：European Journal of Medicinal Chemistry

出版年：2017

9.Chiral resolution of serial potent and selective σ₁ ligands and biological evaluation of (−)-[¹⁸F]TZ3108 in rodent and the nonhuman primate brain

作者：Xuyi Yue^a ; Hongjun Jin^a ; Zonghua Luo^a ; Hui Liu^a ; Xiang Zhang^a ; Ethan D. McSpadden^b ; Linlin Tian^c ; Hubert P. Flores^c ; Joel S. Perlmutter^a ; ^c ; Stanley M. Parsons^b ; Zhude Tu^a ; ^{tuz@mir.wustl.edu}

关键词：calcd ; calculated ; CH2Cl2 ; dichloromethane ; CNS ; central nervous system ; DMSO ; dimethyl sulfoxide ; [3H]DTG ; [3H]ditolylguanidine ; DTTA ; di-p-toluoyl tartaric acid ; EBP ; emopamil binding protein ; ee ; enantiomeric excess ; EOB ; end of bombardment ; EtOH ; ethanol ; [18F]FTC146 ; 18F-6-(3-fluoropropyl)-3-(2-(azepan-1-yl)ethyl)benzo[d]thiazol-2(3H)-one ; HPLC ; high performance liquid chromatography ; HRMS ; high resolution mass spectrometry ; IC50 ; half maximum inhibitory constant ; K2CO3 ; potassium carbonate

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

10.Evaluation of chemical composition and antiedematogenic activity of the essential oil of Hyptis martiusii Benth

作者：Andreza G.R. Barbosa^a ; Cicera D.M. Oliveira^a ; Luiz J. Lacerda-Neto^a ; Cinara S. Vidal^a ; Rogé ; rio de A. Saraiva^a ; José ; G.M. da Costa^b ; Henrique D.M. Coutinho^c ; ^{hdmcoutinho@gmail.com} ; ^{irwinalencar@yahoo.com.br} ; Hericka B.F. Galvao^d ; Irwin R.A. de Menezes^a

关键词：Antiedematogenic activity ; Antiinflammatory effect ; Essential oil ; Hyptis martiusii ; Natural products ; 1 ; 8 cineole

刊名：Saudi Journal of Biological Sciences

出版年：2017

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