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在“Elsevier电子期刊”中，命中：1,304条，耗时：0.0349832 秒

在所有数据库中总计命中：5,706条

1.Identification of a selective inhibitor of transforming growth factor β-activated kinase 1 by biosensor-based screening of focused libraries

作者：Takaaki Miura^a ; ^{miuratka@chugai-pharm.co.jp} ; Atsushi Matsuo^b ; Terushige Muraoka^b ; Mitsuaki Ide^b ; Kenji Morikami^b ; Takayuki Kamikawa^a ; Masamichi Nishihara^b ; Hirotaka Kashiwagi^b

关键词：TAK1 ; Chemogenomic approach ; Selective Type I inhibitor ; Biophysical screening

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

2.Virtual screening and biophysical studies lead to HSP90 inhibitors

作者：Renjie Huang ; Daniel M. Ayine-Tora ; M. Nasri Muhammad Rosdi ; Yu Li ; Jó ; hannes Reynisson ; ^{j.reynisson@auckland.ac.nz} ; Ivanhoe K.H. Leung ; ^{i.leung@auckland.ac.nz}

关键词：17-AAG ; 17-allylamino-17-demethoxygeldanamycin ; 17-DMAG ; 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG) ; ADP ; adenosine diphosphate ; AMPPCP ; 5&prime ; -adenylylmethylenediphosphonate ; ASP ; Astex statistical potential ; ATP ; adenosine triphosphate ; CS ; ChemScore ; GS ; GoldScore ; HB ; hydrogen bonding ; HSP90 ; heat shock protein 90 ; HSQC ; heteronuclear single quantum correlation ; KD ; binding affinity ; ND ; N-domain ; NMR ; nuclear magnetic resonance ; NOE ; nuclear Overhauser effect ; Tm ; pro

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

3.Protein engineering of aldolase LbDERA for enhanced activity toward real substrates with a high-throughput screening method coupled with an aldehyde dehydrogenase

作者：Xue-Cheng Jiao ; Jiang Pan ; ^{panjiang@ecust.edu.cn} ; Xu-Dong Kong ; Jian-He Xu ; ^{jianhexu@ecust.edu.cn}

关键词：Aldehyde dehydrogenase ; Crystal structure ; 2-Deoxyribose-5-phosphate aldolase ; High-throughput screening ; Protein engineering ; Statin side chains

刊名：Biochemical and Biophysical Research Communications

出版年：2017

4.Novel systematic detergent screening method for membrane proteins solubilization

作者：Elodie Desuzinges Mandon¹ ; Morgane Agez¹ ; Rebecca Pellegrin¹ ; Sé ; bastien Igonet ; Anass Jawhari ; ^{ajawhari@calixar.com}

关键词：Extraction ; Solubilization ; Detergent ; Calixarene ; Membrane protein ; Biotinylated lipids ; Membranes ; GPCR ; Transporter

刊名：Analytical Biochemistry

出版年：2017

5.Computational proteome-wide screening predicts neurotoxic drug-protein interactome for the investigational analgesic BIA 10-2474

作者：Steven V. Molinski^a ; Vijay M. Shahani^a ; Stephen S. MacKinnon^a ; Leonard D. Morayniss^a ; Marcon Laforet^a ; Geoffrey Woollard^a ; Naheed Kurji^a ; Cecilia G. Sanchez^b ; Shoshana J. Wodak^a ; Andreas Windemuth^a ; ^{andreas.windemuth@cyclicarx.com}

关键词：BIA 10-2474 (PubChem CID ; 46831476) ; Proteome-docking ; Bioinformatics ; Neurotoxicity ; Drug-protein interactome ; In silico polypharmacology

刊名：Biochemical and Biophysical Research Communications

出版年：2017

6.Co segregation of the m.1555A>G mutation in the MT-RNR1 gene and mutations in MT-ATP6 gene in a family with dilated mitochondrial cardiomyopathy and hearing loss: A whole mitochondrial genome screening

作者：Olfa Alila-Fersi^a ; ^{alilafersiolfa@yahoo.fr} ; Imen Chamkha^b ; Imen Majdoub^c ; Lamia Gargouri^c ; Emna Mkaouar-Rebai^a ; Mouna Tabebi^d ; Abdelaziz Tlili^e ; Leila Keskes^d ; Abdelmajid Mahfoudh^c ; Faiza Fakhfakh^a ; ^{faiza.fakhfakh02@gmail.com}

关键词：Dilated mitochondrial cardiomyopathy ; Hearing loss ; m.1555A>G ; m.8605C>T ; m.8527A>G ; m.8932C>T

刊名：Biochemical and Biophysical Research Communications

出版年：2017

7.Screening ubiquitin specific protease activities using chemically synthesized ubiquitin and ubiquitinated peptides

作者：Marine Bacchi^a ; Benjamin Fould^a ; Magali Jullian^b ; Aude Kreiter^b ; Amé ; lie Maurras^b ; Olivier Nosjean^a ; Thibault Coursindel^b ; Karine Puget^b ; Gilles Ferry^a ; Jean A. Boutin^a ; ^{jean.boutin@servier.com}

关键词：Ubiquitinated peptides ; Chemical synthesis ; Deubiquitinase assay ; HPLC

刊名：Analytical Biochemistry

出版年：2017

8.Ro 90-7501 inhibits PP5 through a novel, TPR-dependent mechanism

作者：Tae-Joon Hong^a ; Kwanghyun Park^a ; Eun-Wook Choi^b ; Ji-Sook Hahn^a ; ^{hahnjs@snu.ac.kr}

关键词：Protein phosphatase 5 (PP5) ; Ro 90-7501 ; Inhibitor screening ; TPR-dependent inhibition

刊名：Biochemical and Biophysical Research Communications

出版年：2017

9.Small molecule absorption by PDMS in the context of drug response bioassays

作者：B.J. van Meer^a ; ^{b.j.vanmeer@lumc.nl} ; H. de Vries^b ; ^{vries_h@lacdr.leidenuniv.nl} ; K.S.A. Firth^c ; ^{mzxksf@nottingham.ac.uk} ; J. van Weerd^d ; ^{j.vanweerd@utwente.nl} ; L.G.J. Tertoolen^a ; ^{l.g.j.tertoolen@lumc.nl} ; H.B.J. Karperien^d ; ^e ; ^{h.b.j.karperien@utwente.nl} ; P. Jonkheijm^d ; ^f ; ^{p.jonkheijm@utwente.nl} ; C. Denning^c ; ^{Chris.Denning@nottingham.ac.uk} ; A.P. IJzerman^b ; ^{ijzerman@lacdr.leidenuniv.nl} ; C.L. Mummery^a ; ^g ; ^{c.l.mummery@lumc.nl}

关键词：PDMS ; Absorption ; Drug screening ; LipoCoat Cellbinder ; PDMS coating ; Microfluidics

刊名：Biochemical and Biophysical Research Communications

出版年：2017

10.A fluorescence-based high-throughput assay to identify inhibitors of tyrosylprotein sulfotransferase activity

作者：Wenbo Zhou ; Yan Wang ; Jiashu Xie ; Robert J. Geraghty ; ^{gerag012@umn.edu}

关键词：TPST ; Sulfotransferase ; High-throughput ; Fluorescence ; Suramin

刊名：Biochemical and Biophysical Research Communications

出版年：2017

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