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在“Elsevier电子期刊”中，命中：20条，耗时：0.1029771 秒

在所有数据库中总计命中：336条

1.Comprehensive in vitro cardiac safety assessment using human stem cell technology: Overview of CSAHi HEART initiative

作者：Kiyoshi Takasuna^a ; ^b ; ^c ; ^{takasuna.kiyoshi.a3@daiichisankyo.co.jp} ; Keiichi Asakura^b ; ^c ; ^d ; Seiichi Araki^b ; ^c ; ^e ; Hiroyuki Ando^b ; ^c ; ^f ; Katsuyuki Kazusa^b ; ^c ; ^g ; Takashi Kitaguchi^b ; ^c ; ^h ; Takeshi Kunimatsu^b ; ^c ; ⁱ ; Shinobu Suzuki^b ; ^c ; ^j ; Norimasa Miyamoto^b ; ^c ; ^k

关键词：CSAHi ; Consortium for Safety Assessment using Human iPS Cells ; FPDc10 ; concentration inducing FPDc prolongation by 10% ; CMIS ; cell motion imaging system ; hiPS-CMs ; human induced pluripotent stem cell-derived cardiomyocytes ; CRD ; contraction-relaxation duration ; IBD10 ; impedance-based duration from 10% rising to 10% falling amplitude ; PWD90 ; peak width duration at 90% amplitude ; MEA ; multi-electrode array ; CPMP ; committee for proprietary medicinal products ; APD ; action potential duration ; TdP ; To

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2017

2.CSAHi study: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes -assessment of inter-facility and cells lot-to-lot-variability-

作者：Yumiko Nozaki^a ; Yayoi Honda^a ; Hitoshi Watanabe^a ; Shota Saiki^b ; ^g ; ¹ ; Kiyotaka Koyabu^b ; Tetsuji Itoh^b ; Chiho Nagasawa^c ; ^g ; ¹ ; Chiaki Nakamori^c ; Chiaki Nakayama^c ; Hiroshi Iwasaki^c ; Shinobu Suzuki^d ; ^g ; ¹ ; Ikumi Washio^d ; Etsushi Takahashi^e ; ^g ; ¹ ; Kaori Miyamoto^e ; Atsuhiro Yamanishi^f ; ^g ; ¹ ; Hiroko Endo^f ; Junko Shinozaki^f ; Hisashi Nogawa^f ; Takeshi Kunimatsu^a ; ^g ; ^h ; ¹ ; ^{takeshi-kunimatsu@ds-pharma.co.jp" class="auth_mail" title="E-mail the corresponding author}

关键词：Consortium for drug safety assessment using human iPS cells (CSAHi) ; Comprehensive in vitro Proarrthythmia assay (CiPA) ; Inter-facility variability ; Multi electrode array (MEA) ; Human iPS cells-derived cardiomyocytes (hiPS-CMs) ; Early after depolarization (EAD) or triggered activity (TA)

刊名：Regulatory Toxicology and Pharmacology

出版年：2016

3.An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy

关键词：PlaNet ; placentology network ; HPTSs ; human placental test systems ; FDA ; Food and Drug Administration ; EMA ; European Medicines Agency ; PLLR ; pregnancy and lactation labelling rule ; IVS ; intervillous space ; HUVEC ; human umbilical vein endothelial cell ; NET ; norepinephrine transporter ; EMT ; extra-neural monoamine transporter ; VMAT2 ; vesicular monoamine transporter 2 ; NOAEL ; no observed adverse effect level ; LOAEL ; lowest observable adverse effect level ; DART ; development and reproductive toxicology

刊名：Reproductive Toxicology

出版年：2016

4.The prospective IQ-CSRC trial: A prototype early clinical proarrhythmia assessment investigation for replacing the ICH E14 thorough QTc (TQT) study

作者：Icilio Cavero^a ; ^{iciliocavero@outlook.com" class="auth_mail" title="E-mail the corresponding author} ; Henry Holzgrefe^b ; Mike Clements^c

关键词：AP ; cardiac action potential ; CiPA ; comprehensive in vitro proarrhythmia assay ; CSRC ; Cardiac Safety Research Consortium ; Cmax ; maximal plasma concentration ; CTWG ; clinical translational working group ; DRest ; rate-normalized Tpeak ; &minus ; ; Tend ; = ; Tpe interval ; ECG ; electrocardiogram ; E-R ; exposure-response ; FDA ; Food and Drug Administration ; FIH ; first-in-humans ; hERG ; human ether-à ; -go-go-related gene ; hiPSC-CMs ; human induced pluripotent stem cell derived cardiomyocyte

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

5.Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats

关键词：DILI ; drug-induced liver injury ; NPC ; non-parenchymal cells ; 2D-sw ; 2D-sandwich ; SM ; safety margin ; MT ; microtissue ; TC ; training compound

刊名：Toxicology Letters

出版年：2016

6.Cross-laboratory analytical validation of the cardiac biomarker NT-proANP in rat

作者：Petra Vinken^a ; ^{pvinken@its.jnj.com" class="auth_mail" title="E-mail the corresponding author} ; William J. Reagan^b ; Luis A. Rodriguez^c ; Wayne R. Buck^d ; Jie Lai-Zhang^d ; Nick Goeminne^a ; Gaby Barbacci^b ; Ray Liu^e ; Nicholas M.P. King^g ; Steven K. Engle^f ; Heidi Colton^c

关键词：Rat ; Cardiac hypertrophy ; Safety biomarker ; Toxicity ; Validation ; NT-proANP ; Natriuretic peptides

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

7.NIEHS/FDA CLARITY-BPA research program update

作者：Jerrold J. Heindel^a ; ^{heindelj@niehs.nih.gov" class="auth_mail" title="E-mail the corresponding author} ; Retha R. Newbold^b ; John R. Bucher^b ; Luí ; sa Camacho^c ; K. Barry Delclos^c ; Sherry M. Lewis^f ; Michelle Vanlandingham^c ; Mona I. Churchwell^c ; Nathan C. Twaddle^c ; Michelle McLellen^c ; Mani Chidambaram^c ; Matthew Bryant^c ; Kellie Woodling^c ; Gonç ; alo Gamboa da Costa^c ; Sherry A. Ferguson^d ; Jodi Flaws^e ; Paul C. Howard^f ; Nigel J. Walker^b ; R. Thomas Zoeller^g ; Jennifer Fostel^b ; Carolyn Favaro^h ; Thaddeus T. Schug^a

关键词：BPA ; bisphenol A ; CLARITY-BPA ; Consortium Linking Academic and Regulatory Insights on BPA Toxicity ; NIEHS ; National Institute of Environmental Health Sciences ; FDA ; United States Food and Drug Administration ; NTP ; National Toxicology Program

刊名：Reproductive Toxicology

出版年：2015

8.The evaluation of drug-induced changes in cardiac inotropy in dogs: Results from a HESI-sponsored consortium

作者：Brian D. Guth^a ; Alan Y. Chiang^b ; Jennifer Doyle^c ; Michael J. Engwall^d ; Jean-Michel Guillon^e ; Peter Hoffmann^f ; John Koerner^g ; Scott Mittelstadt^h ; Sean Ottingerⁱ ; Jennifer Beck Pierson^j ; ; Michael K. Pugsley^k ; Eric I. Rossman^l ; Jacqueline Walisser^m ; R. Dustan Sarazanⁿ

关键词：Myocardial ; Contractility ; Left ventricular dP/dt ; Beagle dog ; Pimobendan ; Atenolol ; Itraconazole ; Amrinone ; Heart rate ; Arterial blood pressure

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2015

9.Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium

作者：Philip T. Sager ; MD ; FACC ; FAHA^a ; ^{psager@stanford.edu" class="auth_mail} ; Gary Gintant ; PhD^b ; J. Rick Turner ; PhD^c ; Syril Pettit ; MEM^d ; Norman Stockbridge ; MD ; PhD^e

刊名：American Heart Journal

出版年：March, 2014

10.Environmental surveys, specimen bank and health related environmental monitoring in Germany

作者：Marike Kolossa-Gehring ; ^{marike.kolossa@uba.de} ; Kerstin Becker ; André ; Conrad ; Christa Schrö ; ter-Kermani ; Christine Schulz ; Margarete Seiwert

关键词：German Environmental Survey (GerES) ; Environmental Specimen Bank (ESB) ; COPHES ; DEMOCOPHES ; Human biomonitoring ; Time trends

刊名：International Journal of Hygiene and Environmental Health

出版年：2012

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