搜索页_+Drug+profiling

常用资源

电子图书

期刊论文

学位会议

在“Elsevier电子期刊”中，命中：1,332条，耗时：0.0359826 秒

在所有数据库中总计命中：18,031条

1.Transcriptome profiling of NIH3T3 cell lines expressing opsin and the P23H opsin mutant identifies candidate drugs for the treatment of retinitis pigmentosa

作者：Yuanyuan Chen^a ; Matthew J. Brooks^b ; Linn Gieser^b ; Anand Swaroop^b ; Krzysztof Palczewski^a ; ^{kxp65@case.edu}

关键词：ad ; autosomal dominant ; BP ; biological process ; CHOP ; C/EBP homologous protein ; CRE ; the cAMP-responsive element ; CREB ; the cAMP-responsive element-binding protein ; CREM ; the cAMP-responsive element modulator ; ATF-1 ; activating transcription factor-1 ; DAVID ; the database for annotation visualization and integrated discovery ; DE ; differential expression ; DMEM ; Dulbecco&rsquo ; s modified Eagle&rsquo ; s medium ; ER ; endoplasmic reticulum ; ERAD ; ER-associated protein degradation ; FDA ; Food and Drug Adm

刊名：Pharmacological Research

出版年：2017

2.Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer

作者：Khalid Saeed^a ; Vesa Rahkama^a ; Samuli Eldfors^a ; Dmitry Bychkov^a ; John Patrick Mpindi^a ; Bhagwan Yadav^a ; Lassi Paavolainen^a ; Tero Aittokallio^a ; Caroline Heckman^a ; Krister Wennerberg^a ; Donna M. Peehl^b ; Peter Horvath^a ; ^c ; Tuomas Mirtti^a ; ^d ; Antti Rannikko^e ; Olli Kallioniemi^a ; ^&dagger ; ; Pä ; ivi Ö ; stling^a ; ^&dagger ; ; Taija M. af Hä ; llströ ; m^a ; ^&dagger ; ; ^{taija.afhallstrom@helsinki.fi}

关键词：Castration-resistant prostate cancer ; Drug sensitivity testing ; Navitoclax ; Patient-derived cultures ; Reprogrammed cells

刊名：European Urology

出版年：2017

3.Comparative study of profiling post-translational modifications of a circulating antibody drug in human with different capture reagents

作者：Yue Zhang^b ; Shiaw-Lin Wu^b ; Yinyin Li^a ; ^{Yinyin.Li@Biogen.com}

关键词：Capture reagent ; In vivo ; PTM ; Affinity purification ; Mass spectrometry ; Human study

刊名：Biologicals

出版年：2017

4.3D engineered In vitro hepatospheroids for studying drug toxicity and metabolism

作者：Swati Chitrangi^a ; Prabha Nair^b ; Aparna Khanna^a ; ^{aparna.khanna@nmims.edu}

关键词：3D ; Three-dimensional ; 2D ; Two-dimensional ; CYP ; cytochrome P450 ; GEVAC ; Gelatin-Vinyl Acetate ; MSCs ; Mesenchymal stem cells ; hUC-MSCs ; human umbilical cord derived-mesenchymal stem cells ; HLCs ; Hepatocyte-like cells ; DMEM-LG ; Dulbecco's Modified Eagle's-low glucose ; FBS ; Fetal Bovine Serum ; CD ; Cluster of Differentiation ; AST ; aspartate aminotransferase ; ALT ; alanine aminotransferase ; HR-LC/MS ; high resolution-liquid chromatography mass spectrometry ; m/z ; mass-to-charge ratio ; 7-AAD ; 7-amino ac

刊名：Toxicology in Vitro

出版年：2017

5.Amine promiscuity and toxicology analysis

作者：Esther C.Y. Lee^a ; ^{esther.lee2@pfizer.com} ; Gregory Steeno^b ; Anne Mai Wassermann^d ; Liying Zhang^c ; Falgun Shah^c ; David A. Price^a

关键词：Amines ; Pharmacological profiling ; Promiscuity ; Toxicology ; Half-life

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

6.Identification of novel therapeutic targets in anaplastic thyroid carcinoma using functional genomic mRNA-profiling: Paving the way for new avenues?

作者：Pascal K.C. Jonker ; MSc^a ; Gooitzen M. van Dam ; MD ; PhD^a ; ^c ; Sjoukje F. Oosting ; MD ; PhD^b ; Schelto Kruijff ; MD ; PhD^a ; ^&dagger ; ; Rudolf S.N. Fehrmann ; MD ; PhD^b ; ^&dagger ; ; ^{R.S.N.Fehrmann@umcg.nl}

刊名：Surgery

出版年：2017

7.The fluorescent two-hybrid assay for live-cell profiling of androgen receptor modulators

作者：Jacqueline Bogner^a ; Kourosh Zolghadr^a ; Ian Hickson^b ; Tina Romer^a ; ^{t.romer@chromotek.com} ; Larisa Yurlova^a

关键词：AR ; androgen receptor protein ; BHK ; baby hamster kidney ; CMV IE ; immediate early promoter of cytomegalovirus ; CRPC ; castration resistant prostate cancer ; CYP17 ; 17α-hydroxy/17 ; 20-lyase ; DAPI ; 4&prime ; 6-diamidino-2-phenylindole ; DBD ; DNA-binding domain ; DHT ; 5α-dihydrotestosterone ; DMEM ; Dulbecco&rsquo ; s Modified Eagle Medium ; DNA ; deoxyribonucleic acid ; F2H ; fluorescent two-hybrid ; FDA ; Food and Drug Administration ; GFP ; green fluorescent protein ; HCA ; high-content analysis ; HEK ; human embryoni

刊名：The Journal of Steroid Biochemistry and Molecular Biology

出版年：2017

8.A profiling study of a newly developed HCVcc strain PR63cc's sensitivity to direct-acting antivirals

作者：Wanyin Tao^a ; ¹ ; Tianyu Gan^a ; ^b ; ¹ ; Jie Lu^a ; ² ; Jin Zhong^a ; ^{jzhong@sibs.ac.cn}

关键词：HCV ; DAA ; Drug resistance ; HCVcc ; Resistance-associated variants

刊名：Antiviral Research

出版年：2017

9.Shrinking the Psoriasis Assessment Gap: Early Gene-Expression Profiling Accurately Predicts Response to Long-Term Treatment

作者：Joel Correa da Rosa¹ ; Jaehwan Kim¹ ; ² ; Suyan Tian³ ; Lewis E. Tomalin² ; ⁴ ; James G. Krueger² ; Mayte Suá ; rez-Fariñ ; as¹ ; ² ; ⁴ ; ⁵ ; ⁶ ; ^{Mayte.SuarezFarinas@mssm.edu}

关键词：AUC ; area under the receiver operating characteristic curve ; PASI ; Psoriasis Area and Severity Index ; PASI75 ; at least 75% reduction in Psoriasis Area and Severity Index score ; UPSC ; universal psoriasis skin classifier

刊名：Journal of Investigative Dermatology

出版年：2017

10.BBB penetration-targeting physicochemical lead selection: Ecdysteroids as chemo-sensitizers against CNS tumors

作者：Judit Mü ; ller^a ; Ana Martins^b ; ¹ ; Jó ; zsef Csá ; bi^c ; Ferenc Fenyvesi^d ; Á ; rpá ; d Kö ; nczö ; l^a ; Attila Hunyadi^c ; ^e ; ^{hunyadi.a@pharm.u-szeged.hu} ; Gyö ; rgy T. Balogh^a ; ^{gy.balogh@richter.hu}

关键词：PAMPA-BBB ; Physicochemical profiling ; Lead selection ; Ecdysteroid ; Cancer ; Adjuvant ; Chemo-sensitization

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

按检索点细分(1332)

题名(144)

关键词(123)

文摘(821)

按出版年细分(1332)

2027年及以后(64)

2017年(25)

2016年(93)

2015年(39)

2013年(112)

2012年(133)

2011年(107)

2010年(78)

2009年(94)

2008年(74)

2007年(81)

2006年(66)

2005年(59)

2004年(95)

2003年(39)

2002年(33)

2001年(40)

2000年(20)

2000年及以前(80)

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700