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在“Elsevier电子期刊”中，命中：103条，耗时：0.1699152 秒

在所有数据库中总计命中：1,213条

1.Prediction of in vivo developmental toxicity by combination of Hand1-Luc embryonic stem cell test and metabolic stability test with clarification of metabolically inapplicable candidates

作者：Hirohisa Nagahori^a ; ^{nagahori@sc.sumitomo-chem.co.jp" class="auth_mail" title="E-mail the corresponding author} ; Noriyuki Suzuki^a ; Florian Le Coz^a ; Takashi Omori^b ; Koichi Saito^a

关键词：EST ; embryonic stem cell test ; ECVAM ; European Center for the Validation of Alternative Methods ; PBPK ; physiologically based pharmacokinetics ; MIC ; metabolically inapplicable candidate ; PBS ; phosphate buffered saline ; DMSO ; dimethyl sulfoxide ; MD ; maximum dose ; ESI ; electrospray ionization ; Rt ; retention time ; Fh ; hepatic availability ; ROC ; receiver operating characteristic curve ; PM ; prediction model ; IC50 ; the concentration that reduces the viability of cells to 50% ; ID50 ; the concentration th

刊名：Toxicology Letters

出版年：2016

2.P71: The development of the test system for assessment of estrogen receptor status, progesterone receptor, HER2/neu and the proliferative factor Ki67 in breast cancer by real time PCR

作者：A. Leshchenko^a ; ; N. Matsenko^a ; ^b

刊名：European Journal of Cancer Supplements

出版年：2015

3.Intra-/inter-laboratory validation study on reactive oxygen species assay for chemical photosafety evaluation using two different solar simulators

作者：Satomi Onoue^a ; ^{onoue@u-shizuoka-ken.ac.jp" class="auth_mail} ; Kazuhiro Hosoi^b ; Tsuguto Toda^c ; Hironori Takagi^d ; Naoto Osaki^d ; Yasuhiro Matsumoto^e ; Satoru Kawakami^f ; Shinobu Wakuri^g ; Yumiko Iwase^h ; Toshinobu Yamamotoⁱ ; Kazuichi Nakamura^j ; Yasuo Ohno^k ; Hajime Kojima^l

关键词：3T3 NRU PT ; 3T3 neutral red uptake phototoxicity test ; 8-MOP ; 8-methoxypsoralen ; CV ; coefficient of variation ; ECVAM ; Europe Center for the Validation of Alternative Methods ; GLP ; Good Laboratory Practice ; ICCVAM ; Interagency Coordinating Committee on the Validation of Alternative Methods ; JaCVAM ; Japanese Center for the Validation of Alternative Methods ; KoCVAM ; Korean Center for the Validation of Alternative Methods ; OECD ; Organisation for Economic Co-operation and Development ; PABA ; p-aminobe

刊名：Toxicology in Vitro

出版年：June, 2014

4.Cryopreservation of human monocytes for pharmacopeial monocyte activation test

作者：Anna Koryakina ^{anna.koryakina@bluewin.ch" class="auth_mail} ; Esther Frey ^{esther.frey@novartis.com" class="auth_mail} ; Peter Bruegger ; ^{peter.bruegger@novartis.com" class="auth_mail}

关键词：BET ; bacterial endotoxins test ; BSA ; bovine serum albumin ; DPBS ; Dulbecco's phosphate buffered saline ; ECVAM ; European Centre for the Validation of Alternative Methods ; EDQM ; European Directorate for the Quality of Medicines & Health Care ; ELISA ; enzyme-linked immunosorbent assay ; EU ; European Union ; GMP ; good manufacturing practice ; ICH ; International Conference on Harmonization ; IL-1尾 ; interleukin-1尾 ; IL-6 ; interleukin-6 ; MAT ; monocyte activation test ; NF魏B ; nuclear factor kappa B ; PBMCs ; p

刊名：Journal of Immunological Methods

出版年：March, 2014

5.Individual and combined developmental toxicity assessment of bisphenol A and genistein using the embryonic stem cell test in vitro

作者：Dan Kong ; Lina Xing ; Ran Liu ; Jianjun Jiang ; Wanyi Wang ; Lanqin Shang ; Xuetao Wei ; Weidong Hao

关键词：EBs ; embryonic bodies ; ECETOC ; European Centre for Ecotoxicology and Toxicology of Chemicals ; ECVAM ; European Center for the Validation of Alternative Methods ; EEDs ; environmental endocrine disruptors ; EEs ; environmental estrogens ; ER ; estrogen receptors

刊名：Food and Chemical Toxicology

出版年：2013

6.Non-animal photosafety assessment approaches for cosmetics based on the photochemical and photobiochemical properties

作者：Satomi Onoue ; Gen Suzuki ; Masashi Kato ; Morihiko Hirota ; Hayato Nishida ; Masato Kitagaki ; Hirokazu Kouzuki ; Shizuo Yamada

关键词：3T3 NRU PT ; 3T3 neutral red uptake phototoxicity testing ; ANOVA ; one-way analysis of variance ; CMC ; critical micelle concentration ; DMSO ; dimethyl sulfoxide ; ECVAM ; European Centre for the Validation of Alternative Methods ; ICH ; International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use ; IFRA ; International Fragrance Association ; JaCVAM ; Japanese Center for the Validation of Alternative Methods ; JPMA ; Japan Pharmaceutical Manufacturers A

刊名：Toxicology in Vitro

出版年：December, 2013

7.Evaluation of chemicals requiring metabolic activation in the EpiDerm? 3D human reconstructed skin micronucleus (RSMN) assay

作者：Marilyn J. Aardema^a ; Brenda B. Barnett^b ; Greg C. Mun^c ; Erica L. Dahl^d ; Rodger D. Curren^c ; Nicola J. Hewitt^e ; ^{nickyhewittltd@yahoo.co.uk} ; Stefan Pfuhler^f

关键词：Reconstructed skin ; Genotoxicity ; Micronucleus ; Bio-activation ; Genotoxins

刊名：Mutation Research/Genetic Toxicology and Environmental Mutagenesis

出版年：2013

8.Gene expression changes induced by skin sensitizers in the KeratinoSens鈩?cell line: Discriminating Nrf2-dependent and Nrf2-independent events

作者：Roger Emter ; Jochem W. van der Veen ; Greg Adamson ; Janine Ezendam ; Henk van Loveren ; Andreas Natsch

关键词：LLNA ; local lymph node assay ; Nrf2 ; nuclear factor-erythroid 2-related factor 2 ; Keap1 ; Kelch-like ECH-associated protein 1 ; ARE ; antioxidant response element ; FCS ; fetal calf serum ; qRT-PCR ; quantitative real time polymerase chain reaction ; DMSO ; dimethylsulfoxide ; DNCB ; 2 ; 4-dinitrochlorobenzene ; SDS ; sodium dodecyl sulfate

刊名：Toxicology in Vitro

出版年：December, 2013

9.P-92 - Avatar based recovery platform: new directions in the treatment of chemical dependency

作者：I. Steigman

刊名：European Psychiatry

出版年：2012

10.Combined developmental toxicity of bisphenol A and genistein in micromass cultures of rat embryonic limb bud and midbrain cells

作者：Yang Xiao^a ; ¹ ; Ran Liu^a ; ¹ ; ^{rliu1985@yahoo.cn} ; Lina Xing^a ; Yajun Xu^b ; Lanqin Shang^a ; Weidong Hao^a ; ^{whao@bjmu.edu.cn}

关键词：Bisphenol A ; Genistein ; Micromass ; Developmental toxicity ; Combined effect

刊名：Toxicology in Vitro

出版年：2011

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