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在“Elsevier电子期刊”中，命中：9,003条，耗时：0.0569744 秒

在所有数据库中总计命中：48,993条

1.Label-free fluorescent assay of T4 polynucleotide kinase phosphatase activity based on G-quadruplexe−thioflavin T complex

作者：Hengzhi Zhao^a ; Qiang Liu^b ; Mei Liu^b ; Yan Jin^a ; Baoxin Li^a ; ^{libaoxin@snnu.edu.cn}

关键词：T4 polynucleotide kinase phosphatase ; Thioflavin T ; Fluorescence assay ; Label-free

刊名：Talanta

出版年：2017

2.A graphene oxide-based multiplexed fluorescence assay for the detection of protein kinase activity in cell lysates and the evaluation of protein kinase inhibition

作者：Yong Huang ; ^{huangyong_2009@163.com" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Huakui Huang ; Jian Qin ; Xiaoqian Liu ; Shulin Zhao ; ^{zhaoshulin001@163.com" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Zhen-Feng Chen ; Hong Liang ; ^{hliang@gxnu.edu.cn" class="auth_mail" title="E-mail the corresponding author}Author Vitae

关键词：Graphene oxide ; Multiplexed detection ; Protein kinase ; Cell lysates

刊名：Sensors & Actuators: B. Chemical

出版年：2017

3.LC-MS/MS assay for the quantitation of the tyrosine kinase inhibitor neratinib in human plasma

作者：Brian F. Kiesel^a ; ^b ; Robert A. Parise^a ; Alvin Wong^c ; Kiana Keyvanjah^c ; Samuel Jacobs^d ; Jan H. Beumer^a ; ^b ; ^e ; ^{beumerj@gmail.com}

关键词：Neratinib ; Tandem mass spectrometry ; Assay ; Validation

刊名：Journal of Pharmaceutical and Biomedical Analysis

出版年：2017

4.Inhibition of Focal Adhesion Kinase on Hepatic Stellate-cell Adhesion and Migration

作者：Yan Wang ; MD ; PhD ; Junji Ma ; MD ; PhD ; Lei Chen ; MD ; PhD ; Xiao-Li Xie ; PhD ; Huiqing Jiang ; MD ; PhD ; ^{jianghuiqing1959@sina.com}

关键词：Hepatic stellate cells ; Adhesion ; Migration ; Focal adhesion kinase&ndash ; related nonkinase ; Phosphatidylinositol 3-kinase

刊名：The American Journal of the Medical Sciences

出版年：2017

5.A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore

作者：Yihui Shi ; Jaehyeon Park ; Chandraiah Lagisetti ; Wei Zhou ; Lidia C. Sambucetti ; Thomas R. Webb ; ^{thomas.webb@sri.com}

关键词：CLK ; cdc2-like kinase ; MDM2 ; mouse double minute 2 homolog ; Luc ; luciferase ; TEA ; triethylamine ; DIPEA ; diisopropylethylamine ; EtOAc ; ethyl acetate

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

6.Perilla frutescens leaves extract ameliorates ultraviolet radiation-induced extracellular matrix damage in human dermal fibroblasts and hairless mice skin

作者：Jung-Soo Bae^a ; ^b ; ^c ; ¹ ; Mira Han^a ; ^b ; ^c ; ¹ ; Hee Soon Shin^d ; Min-Kyoung Kim^a ; ^b ; ^c ; Chang-Yup Shin^a ; ^b ; ^c ; Dong Hun Lee^a ; ^b ; ^c ; ^{ivymed27@snu.ac.kr} ; Jin Ho Chung^a ; ^b ; ^c ; ^e ; ^{jhchung@snu.ac.kr}

关键词：AP-1 ; activator protein-1 ; ECM ; extracellular matrix ; EMSA ; electrophoretic mobility shift assays ; ERK ; extracellular signal-regulated kinase ; HDF ; human dermal fibroblast ; JNK ; c-Jun N-terminal kinase ; MED ; minimal erythema dose ; MMP ; matrix metalloproteinases ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)&minus2 ; 5-diphenyltetrazolium bromide ; PBS ; phosphate-buffered saline ; PLE ; Perilla frutescens leaves extract ; ROS ; reactive oxygen species ; SDS-PAGE ; sodium dodecyl sulfate-polyacrylamide gel electropho

刊名：Journal of Ethnopharmacology

出版年：2017

7.IκB kinase inhibition as a potential treatment of osteoarthritis - results of a clinical proof-of-concept study

作者：K. Grothe^&dagger ; ; ^{Kirsten.Grothe@sanofi.com} ; K. Flechsenhar^&dagger ; ; ^{Klaus.Flechsenhar@sanofi.com} ; T. Paehler^&Dagger ; ; ^{Tobias.Paehler@sanofi.com} ; O. Ritzeler^§ ; ; ^{Olaf.Ritzeler@sanofi.com} ; J. Beninga^‖ ; ^{Jochen.Beninga@sanofi.com} ; J. Saas^&dagger ; ; ^{Joachim.Saas@sanofi.com} ; M. Herrmann^&dagger ; ; ^{Matthias.Herrmann@sanofi.com} ; K. Rudolphi^&dagger ; ; ^{Karl.Rudolphi@sanofi.com}

关键词：IκB kinase inhibitor ; Slow-release formulation ; Intra-articular injection ; Treatment of knee osteoarthritis ; Clinical findings

刊名：Osteoarthritis and Cartilage

出版年：2017

8.Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor

作者：Lyamin Z. Bendjeddou^a ; ^b ; Nadè ; ge Loaë ; c^a ; Benoî ; t Villiers^a ; Eric Prina^c ; Gerald F. Spä ; th^c ; Hervé ; Galons^b ; Laurent Meijer^a ; ^{meijer@manros-therapeutics.com} ; Nassima Oumata^a ; ^{oumata@manros-therapeutics.com}

关键词：Kinase inhibitor ; Imidazo[1 ; 2-b]pyridazine ; Unicellular parasites ; Leishmania ; DYRK1A ; CLKs

刊名：European Journal of Medicinal Chemistry

出版年：2017

9.Integrated bioinformatics, computational and experimental methods to discover novel Raf/extracellular-signal regulated kinase (ERK) dual inhibitors against breast cancer cells

作者：Yin Chen^a ; ¹ ; Yaxin Zheng^a ; ¹ ; Qinglin Jiang^a ; ^b ; ¹ ; Feifei Qin^a ; Yonghui Zhang^c ; Leilei Fu^a ; ^{leilei_fu@163.com} ; Gu He^a ; ^{hegu@scu.edu.cn}

关键词：Breast cancer ; Raf ; ERK ; Bioinformatics ; Kinase inhibitor

刊名：European Journal of Medicinal Chemistry

出版年：2017

10.Potentiation and tolerance of toll-like receptor priming in human endothelial cells

作者：Stephen R. Koch^a ; Fred S. Lamb^a ; Judith Hellman^b ; Edward R. Sherwood^c ; Ryan J. Stark^a ; ^{ryan.stark@vanderbilt.edu}

关键词：ELISA ; enzyme-linked immunosorbent assay ; ERK ; extracellular signal-regulated kinase ; HMVEC ; human dermal microvascular endothelial cell ; HUVEC ; human umbilical vein endothelial cell ; IL-6 ; interleukin 6 ; IKK ; IκB kinase ; IP-10 ; interferon gamma-induced protein 10 ; IRF ; interferon regulatory factor ; JNK ; c-Jun amino-terminal kinase ; LPS ; lipopolysaccharide ; LTA ; lipoteichoic acid ; MAPK ; mitogen-activated protein kinase ; MyD88 ; myeloid differentiation primary response gene 88 ; Nec-1s ; 7-Cl-O-Nec1

刊名：Translational Research

出版年：2017

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