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在“Elsevier电子期刊”中，命中：1,112条，耗时：0.2079033 秒

在所有数据库中总计命中：18,048条

1.Discovery of new MurA inhibitors using induced-fit simulation and docking

作者：Kaja Rožman^a ; Samo Le&scaron ; nik^b ; Boris Brus^a ; Martina Hrast^a ; Matej Sova^a ; Delphine Patin^c ; Hé ; lè ; ne Barreteau^c ; Janez Konc^b ; ^d ; Du&scaron ; anka Janežič^d ; ^{dusanka.janezic@upr.si} ; Stanislav Gobec^a ; ^{stanislav.gobec@ffa.uni-lj.si}

关键词：MurA inhibitors ; ProBiS-CHARMMing web server ; Induced fit ; Small-molecule inhibitors ; Antibacterial agents

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

2.Interference between Triplex and Protein Binding to Distal Sites on Supercoiled DNA

作者：Agnes Noy¹ ; Anthony Maxwell² ; Sarah A. Harris³ ; ⁴ ; ^{s.a.harris@leeds.ac.uk}

刊名：Biophysical Journal

出版年：2017

3.Probing the structure of the uncoupled nicotinic acetylcholine receptor

作者：Jiayin Sun ; J. Frederique Comeau ; John E. Baenziger ; ^{John.Baenziger@uottawa.ca}

关键词：ACh ; acetylcholine ; α-BTX ; α-bungarotoxin ; Carb ; carbamylcholine ; Chol ; cholesterol ; ECD ; extracellular domain ; ELIC ; Erwinia ligand-gated ion channel ; GLIC ; Gloebacter ligand-gated ion channel ; nAChR ; nicotinic acetylcholine receptor ; PA ; 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidic acid ; PC ; 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine ; pLGIC ; pentameric ligand-gated ion channel ; TID ; 3-trifluoromethyl-3-(m-[125I]iodophenyl) diazirine ; TMD ; transmembrane domain

刊名：Biochimica et Biophysica Acta (BBA) - Biomembranes

出版年：2017

4.Binding characterization, synthesis and biological evaluation of RXRα antagonists targeting the coactivator binding site

作者：Dingyu Xu^a ; ^&dagger ; ; Shangjie Guo^a ; ^&dagger ; ; Ziwen Chen^a ; Yuzhou Bao^a ; Fengyu Huang^a ; Dan Xu^a ; Xindao Zhang^a ; Zhiping Zeng^a ; Hu Zhou^a ; Xiaokun Zhang^a ; ^b ; Ying Su^a ; ^b ; ^{ysu@sbpdiscovery.org" class="auth_mail" title="E-mail the corresponding author}

关键词：Nuclear receptors ; RXRα modulators ; Coregulator-binding site ; Coactivator-binding site ligand ; TNFα/NF-κB pathway

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

5.Structural Insights into the Inhibitory Mechanism of an Antibody against B7-H6, a Stress-Induced Cellular Ligand for the Natural Killer Cell Receptor NKp30

作者：Xiaoping Xu¹ ; ² ; ^&dagger ; ; Emilie Narni-Mancinelli³ ; ^&dagger ; ; Claudia Cantoni⁴ ; ⁵ ; ⁶ ; ^&dagger ; ; Yili Li¹ ; ⁷ ; ^&dagger ; ; Sophie Guia³ ; Laurent Gauthier⁸ ; Qianming Chen² ; Alessandro Moretta⁴ ; ⁵ ; Fré ; dé ; ric Vé ; ly³ ; ⁹ ; Edward Eisenstein¹ ; ¹⁰ ; Sneha Rangarajan¹ ; ⁷ ; Eric Vivier³ ; ^{vivier@ciml.univ-mrs.fr" class="auth_mail" title="E-mail the corresponding author} ; Roy A. Mariuzza¹ ; ⁷ ; ^{rmariuzz@umd.edu" class="auth_mail" title="E-mail the corresponding author} ; ^{mariuzza@ibbr.umd.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：NK ; natural killer ; MHC ; major histocompatibility complex ; MHC-I ; major histocompatibility complex class I ; IgV ; Ig variable ; CDR ; complementarity-determining region ; IgG ; Immunoglobulin G ; mAb ; monoclonal antibody ; V ; variable ; C ; constant ; Fab ; antigen-binding fragment ; wt ; wild-type ; FcR ; Fc receptor ; ORF ; open reading frame

刊名：Journal of Molecular Biology

出版年：2016

6.Challenges of docking in large, flexible and promiscuous binding sites

作者：Martin Kotev^a ; Robert Soliva^b ; Modesto Orozco^a ; ^c ; ^{modesto.orozco@irbbarcelona.org" class="auth_mail" title="E-mail the corresponding author}

关键词：Induced-fit docking ; PELE simulations ; Soluble Epoxide Hydrolase ; Benchmark

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

7.Polypharmacology of dopamine receptor ligands

作者：S. Butini^a ; K. Nikolic^b ; S. Kassel^c ; H. Brü ; ckmann^c ; S. Filipic^b ; D. Agbaba^b ; S. Gemma^a ; S. Brogi^a ; M. Brindisi^a ; G. Campiani^a ; H. Stark^c ; ^{stark@hhu.de" class="auth_mail" title="E-mail the corresponding author} ; ^{h.stark@zafes.de" class="auth_mail" title="E-mail the corresponding author}

关键词：ACh ; acetylcholine ; AC ; adenylyl cyclase ; APO ; apomorphine ; PD ; Parkinson&rsquo ; s disease ; CNS ; central nervous system ; COMT ; catecholamine O-methyl transferase ; DML ; designed multiple ligands ; L-DOPA ; L-3 ; 4-dihydroxyphenylalanine ; LID ; L-DOPA induced dyskinesia ; DAT ; dopamine reuptake transporter ; EPS ; extrapyramidal symptoms ; GABA ; γ-aminobutyric acid ; IBS ; imidazole binding site ; MAO ; monoamine oxidase ; NET ; norepinephrine reuptake transporter ; SERT ; serotonin reuptake transporter ; THPB ; tetr

刊名：Progress in Neurobiology

出版年：2016

8.Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer’s disease based on the fusion of donepezil and melatonin

作者：Jin Wang ; Zhi-Min Wang ; Xue-Mei Li ; Fan Li ; Jia-Jia Wu ; Ling-Yi Kong ; ^{cpu_lykong@126.com" class="auth_mail" title="E-mail the corresponding author} ; Xiao-Bing Wang ; ^{xbwang@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：AchE ; Acetylcholinesterase ; BuChE ; Butyrylcholinesterase ; AD ; Alzheimer&rsquo ; s disease ; Aβ ; β-Amyloid ; CAS ; Catalytic anionic site ; PAS ; Peripheral anionic site ; BBB ; Blood&ndash ; brain barrier ; AβOs ; Soluble Aβ oligomers ; CNS ; Central nervous system ; NFTS ; Neurofibrillary tangles ; ChEs ; Cholinesterases ; ChEIs ; Cholinesterase inhibitors ; CDI ; 1 ; 1&prime ; -Carbonyldiimidazole ; ORAC ; Oxygen radical absorbance capacity ; PAMPA ; Parallel artificial membrane permeation assay

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

9.DF2755A, a novel non-competitive allosteric inhibitor of CXCR1/2, reduces inflammatory and post-operative pain

作者：Alexandre H. Lopes^a ; ^d ; Laura Brandolini^b ; ^d ; Andrea Aramini^b ; ^d ; Gianluca Bianchini^b ; ^d ; Rangel L. Silva^a ; ^d ; Ana C. Zaperlon^c ; ^d ; Waldiceu A. Verri Jr.^c ; ^d ; José ; C. Alves-Filho^a ; ^d ; Fernando Q. Cunha^a ; ^d ; Mauro M. Teixeira^c ; ^d ; Marcello Allegretti^b ; ^d ; ^{marcello.allegretti@dompe.it" class="auth_mail" title="E-mail the corresponding author} ; Thiago M. Cunha^a ; ^d ; ^{thicunha@fmrp.usp.br" class="auth_mail" title="E-mail the corresponding author}

关键词：CXCR1/2 ; chemokine (C-X-C motif) receptor 1/2 ; LPS ; lipopolysaccharide ; CFA ; complete freund&rsquo ; s adjuvant ; CXCL8 ; chemokine (C-X-C motif) ligand 8 ; CNS ; central nervous system ; PMN ; polymorphonuclear cell family ; HBSS ; Hanks&rsquo ; balanced salt solution ; PGE2 ; prostaglandin E2 ; TRPV1 ; transient receptor potential cation channel subfamily V member 1 ; CGRP ; calcitonin gene related peptide ; ERK ; extracellular-signal-regulated kinases ; NMDA ; N-methyl-D-aspartate

刊名：Pharmacological Research

出版年：2016

10.Fibroblast growth factor 2 dimer with superagonist in vitro activity improves granulation tissue formation during wound healing

作者：Caitlin G. Decker^a ; Yu Wang^e ; Samantha J. Paluck^a ; Lu Shen^a ; Joseph A. Loo^a ; ^b ; Alex J. Levine^a ; ^c ; ^d ; Lloyd S. Miller^e ; Heather D. Maynard^a ; ^{maynard@chem.ucla.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Wound healing ; Diabetic wounds ; Growth factor ; PEGylation ; Dimerization ; Angiogenesis

刊名：Biomaterials

出版年：2016

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