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在“Elsevier电子期刊”中，命中：2,758条，耗时：0.1349357 秒

在所有数据库中总计命中：28,584条

1.Muropeptide signature of inhibitors of protein synthesis correlates with β-lactam synergism against methicillin-resistant Staphylococcus aureus

作者：Bertrand Guignard^a ; ^b ; ^{Bertrand.Guignard@hcuge.ch} ; Paul A. Majcherczyk^a ; Cé ; dric Monachon^a ; Jacques Vouillamoz^a ; Philippe Moreillon^a

关键词：β-Lactams ; Protein synthesis inhibitors ; Muropeptide ; Methicillin-resistant Staphylococcus aureus ; Quinupristin/dalfopristin ; Synergism

刊名：International Journal of Antimicrobial Agents

出版年：2017

2.Rational design, synthesis, and structure-activity relationships of 5-amino-1H-pyrazole-4-carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors

作者：Sujay Basu ; ^{sujay.basu@advinus.com} ; Philip Prathipati ; Sachin Thorat ; Shariq Ansari ; Meena Patel ; Vaibhav Jain ; Ramana R. Jinugu ; Sanjay Niranjan ; Siddhartha De ; Satyanarayana Reddy

关键词：Protein tyrosine phosphatase 1B ; Pharmacophore ; Permeability ; Hydrophobic ; Oxadiazole

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

3.Synthesis and structure activity relationships of glycine amide derivatives as novel Vascular Adhesion Protein-1 inhibitors

作者：Susumu Yamaki ; ^{susumu.yamaki@astellas.com} ; Daisuke Suzuki ; Jiro Fujiyasu ; Masahiro Neya^&dagger ; ; Akira Nagashima ; Mitsuhiro Kondo ; Takafumi Akabane ; Keitaro Kadono ; Ayako Moritomo ; Kosei Yoshihara^&Dagger ;

关键词：Vascular Adhesion Protein-1 ; Diabetic microvascular complication ; Glycine amide ; PAMPA

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

4.Design, synthesis and pharmacological evaluation of 4,5-diarylisoxazols bearing amino acid residues within the 3-amido motif as potent heat shock protein 90 (Hsp90) inhibitors

作者：Chi Zhang^a ; ^c ; ¹ ; Xin Wang^b ; ^d ; ¹ ; Hongchun Liu^b ; Minmin Zhang^b ; Meiyu Geng^b ; Liping Sun^a ; ^{chslp@cpu.edu.cn} ; Aijun Shen^b ; ^{shenaj@simm.ac.cn} ; Ao Zhang^c ; ^{aozhang@simm.ac.cn}

关键词：Diarylisoxazole ; Resorcinol ; Amino acid ; Hsp90 inhibitor ; Antiproliferative effect

刊名：European Journal of Medicinal Chemistry

出版年：2017

5.Identification and validation of small molecule modulators of the NusB-NusE interaction

作者：Peter J. Cossar^a ; ³ ; Cong Ma^b ; ² ; ³ ; Christopher P. Gordon^a ; ¹ ; Joseph I. Ambrus^a ; Peter J. Lewis^b ; Adam McCluskey^a ; ^{Adam.McCluskey@newcastle.edu.au}

关键词：Protein-protein interaction ; NusB-NusE ; Antibiotic ; Pharmacophore ; In silico screening

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

6.Discovery of new MurA inhibitors using induced-fit simulation and docking

作者：Kaja Rožman^a ; Samo Le&scaron ; nik^b ; Boris Brus^a ; Martina Hrast^a ; Matej Sova^a ; Delphine Patin^c ; Hé ; lè ; ne Barreteau^c ; Janez Konc^b ; ^d ; Du&scaron ; anka Janežič^d ; ^{dusanka.janezic@upr.si} ; Stanislav Gobec^a ; ^{stanislav.gobec@ffa.uni-lj.si}

关键词：MurA inhibitors ; ProBiS-CHARMMing web server ; Induced fit ; Small-molecule inhibitors ; Antibacterial agents

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

7.Hyaluronan carried by tumor-derived microvesicles induces IL-10 production in classical (CD14⁺⁺CD16⁻) monocytes via PI3K/Akt/mTOR-dependent signalling pathway

作者：Marzena Lenart^a ; Magdalena Rutkowska-Zapala^a ; Monika Baj-Krzyworzeka^a ; Rafał Szatanek^a ; Kazimierz Węglarczyk^a ; Timothy Smallie^b ; Lö ; ms Ziegler-Heitbrock^c ; ^d ; Marek Zembala^a ; Maciej Siedlar^a ; ^{misiedla@cyf-kr.edu.pl" class="auth_mail" title="E-mail the corresponding author}

关键词：DCs ; dendritic cells ; HA ; hyaluronan ; IRF ; interferon regulatory factor ; MOI ; multiplicity of infection ; PKB ; protein kinase B ; RNI ; reactive nitrogen intermediates ; ROI ; reactive oxygen species ; mTOR ; mammalian target of rapamycin ; TIM ; tumor-infiltrating monocytes/macrophages ; TMV ; tumor microvesicles

刊名：Immunobiology

出版年：2017

8.Macrocyclic MEK1/2 inhibitor with efficacy in a mouse model of cardiomyopathy caused by lamin A/C gene mutation

作者：Wei Wu^a ; ^b ; Mahendra D. Chordia^c ; ^g ; Barry P. Hart^d ; E. Sathyajith Kumarasinghe^c ; Min K. Ji^c ; Ajay Bhargava^e ; Michael W. Lawlor^f ; Ji-Yeon Shin^a ; ^b ; Fusako Sera^a ; Shunichi Homma^a ; Antoine Muchir^a ; ^b ; ^h ; Uday R. Khire^c ; ^d ; ^{ukhire@allomek.com} ; Howard J. Worman^a ; ^b ; ^{hjw14@columbia.edu}

关键词：Cardiomyopathy ; Emery-Dreifuss muscular dystrophy ; Extracellular signal-regulated kinase ; Lamin ; MEK inhibitor ; Mitogen-activated protein kinase

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

9.Novel reversible methionine aminopeptidase-2 (MetAP-2) inhibitors based on purine and related bicyclic templates

作者：Timo Heinrich^a ; ^{timo.heinrich@merckgroup.com} ; Hans-Peter Buchstaller^a ; Bertram Cezanne^b ; Felix Rohdich^c ; Jö ; rg Bomke^a ; Manja Friese-Hamim^d ; Mireille Krier^a ; Thorsten Knö ; chel^e ; Djordje Musil^a ; Birgitta Leuthner^a ; Frank Zenke^f

关键词：MetAP2 ; Methionine aminopeptidase 2 ; Metalloprotease ; Purine

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

10.Targeting nuclear thymidylate biosynthesis

作者：James Chon^a ; Patrick J. Stover^a ; ^b ; Martha S. Field^b ; ^{mas246@cornell.edu}

关键词：Nuclear thymidylate synthesis ; Antifolate ; Folate-mediated one-carbon metabolism ; Sumoylation ; Thymidylate synthase

刊名：Molecular Aspects of Medicine

出版年：2017

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