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在“Elsevier电子期刊”中，命中：34条，耗时：小于0.01 秒

1.Acute cardiovascular safety of two formulations of beclometasone dipropionate/formoterol fumarate in COPD patients: A single-dose, randomised, placebo-controlled crossover study

作者：Dave Singh^a ; ^{DSingh@meu.org.uk} ; Giorgia Ciurlia^b ; Annalisa Piccinno^b ; Annamaria Muraro^b ; Maria Bocchi^b ; Mario Scuri^b

关键词：β2-agonist ; Cardiovascular ; Safety ; COPD

刊名：Pulmonary Pharmacology & Therapeutics

出版年：2017

2.Evaluation of the Effect of Selumetinib on Cardiac Repolarization: A Randomized, Placebo- and Positive-controlled Crossover QT/QTc Study in Healthy Subjects

作者：Diansong Zhou ; PhD¹ ; ^{diansong.zhou@astrazeneca.com} ; Karen So ; MD² ; Angela W. Dymond ; MSc³ ; ^⁎ ; Torbjorn Vik ; MD⁴ ; Nidal Al-Huniti ; PhD¹ ; Gabriella Mariani ; MD² ; Gyorgy Zorenyi ; MD³ ; Yifan Huang ; PhD⁵ ; Victoria Holmes ; PhD² ; Paul Severin ; BSc⁶ ; Scott Rasmussen ; MD⁷ ; Paul Martin ; PhD³ ; ^&dagger ;

关键词：cardiac repolarization ; pharmacodynamics ; pharmacokinetics ; QTc ; selumetinib

刊名：Clinical Therapeutics

出版年：2016

3.Differentiating the Effect of an Opioid Agonist on Cardiac Repolarization From µ-Receptor-mediated, Indirect Effects on the QT Interval: A Randomized, 3-way Crossover Study in Healthy Subjects

作者：Borje Darpo ; MD ; PhD¹ ; ² ; ^{borje.darpo@telia.com" class="auth_mail" title="E-mail the corresponding author} ; Meijian Zhou ; PhD² ; Stephen A. Bai ; PhD³ ; ^⁎ ; Georg Ferber ; PhD⁴ ; Qinfang Xiang ; PhD³ ; Andrew Finn ; PharmD⁵

关键词：µ ; -receptor blockade ; buprenorphine ; naltrexone ; opioids ; QT prolongation ; thorough QT study

刊名：Clinical Therapeutics

出版年：2016

4.Intravenous Dosing as an Alternate Approach to Safely Achieve Supratherapeutic Exposure for Assessments of Cardiac Repolarization: A Randomized Clinical Trial with Mavoglurant (AFQ056)

作者：Mike Ufer ; MD ; PhD¹ ; ^{mike.ufer@novartis.com} ; Alexandros Sagkriotis ; PhD¹ ; Atish Salunke ; MPharm² ; Subramanian Ganesan ; PhD² ; ^* ; ^&dagger ; ; Anne Tisserant ; PhD¹ ; Angela Dodman ; PhD¹ ; Emilie Voltz ; PhD¹ ; Ralph Woessner ; PhD¹ ; Pierre Jordaan ; MD¹ ; Eric Legangneux ; MD¹

关键词：central nervous system ; cardiac repolarization ; intravenous ; healthy individuals ; QTc interval

刊名：Clinical Therapeutics

出版年：2016

5.Pharmacokinetic drug interaction study between overactive bladder drugs mirabegron and tolterodine in Japanese healthy postmenopausal females

作者：Yuki Nomura^a ; ^{yuki.nomura@astellas.com} ; Hiromi Iitsuka^a ; Junko Toyoshima^a ; Kentaro Kuroishi^b ; Toshifumi Hatta^a ; Atsunori Kaibara^a ; Masataka Katashima^a ; Selina Moy^c ; Taiji Sawamoto^a

关键词：Mirabegron ; Tolterodine ; Drug&ndash ; drug interaction ; Pharmacokinetics and drug metabolism ; Overactive bladder ; Japanese

刊名：Drug Metabolism and Pharmacokinetics

出版年：2016

6.The positive frequency-dependent electrophysiological effects of the I_Kur inhibitor XEN-D0103 are desirable for the treatment of atrial fibrillation

作者：John Ford ; PhD^* ; James Milnes ; PhD^* ; Said El Haou ; PhD^* ; Erich Wettwer ; PhD^&dagger ; ; Simone Loose ; MD^&dagger ; ; Klaus Matschke ; MD^&Dagger ; ; Benoit Tyl ; MD^§ ; ; Patrick Round ; MBBS^* ; Ursula Ravens ; MD^&dagger ; ; ^{ravens@rcs.urz.tu-dresden.de" class="auth_mail" title="E-mail the corresponding author}

关键词：AF ; atrial fibrillation ; ANOVA ; analysis of variance ; AP ; action potential ; APA ; action potential amplitude ; APD20 ; APD50 ; APD90 ; action potential duration at 20% ; 50% ; and 90% of repolarization ; cAF ; chronic atrial fibrillation ; DMSO ; dimethyl sulfoxide ; dV/dtmax ; maximum upstroke velocity ; ECG ; electrocardiogram/electrocardiographic ; ERP ; effective refractory period ; HR ; heart rate ; IKur ; ultra-rapidly activating delayed-rectifier potassium current ; pAF ; paroxysmal atrial fibrillation ; PLT20

刊名：Heart Rhythm

出版年：2016

7.Interaction complexe des gonadotrophines et des stéroïdes sur l’intervalle QT

作者：G. Abehsira (Dr) ; F. Badilini (Dr) ; L. Koehl ; M. Lebot ; C. Favet (Dr) ; C. Funck Brentano (Pr) ; P. Touraine (Pr) ; J.E. Salem (Dr) ; A. Bachelot ; ^{anne.bachelot@aphp.fr" class="auth_mail" title="E-mail the corresponding author} (Pr)

刊名：Annales d'Endocrinologie

出版年：2016

8.QT interval correction assessment in the anesthetized guinea pig

作者：Pierre Morissette ; ^{pierre_morissette@merck.com" class="auth_mail" title="E-mail the corresponding author} ; Hillary K. Regan ; Kevin Fitzgerald ; Sylvain Bernasconi¹ ; Pamela Gerenser ; Jeffrey Travis ; Patrick Fanelli ; Frederick Sannajust ; Christopher P. Regan

关键词：ANES GP ; anesthetized guinea pig ; BP ; blood pressure ; BT ; body temperature ; GP ; guinea pig ; hERG ; human ether-a-go-go related gene ; IKr ; rapidly-activating delayed rectifier potassium current ; IKs ; slowly-activating delayed rectifier potassium current ; MAP ; mean arterial pressure ; NCE ; new chemical entity ; NBE ; new biological entity ; QTc ; heart rate corrected QT interval ; QTcb ; Bazett's heart rate QT corrected interval ; QTcf ; Fridericia's heart rate QT corrected interval ; QTcVdW ; Van de Water's

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2015

9.Effects of Therapeutic and Supratherapeutic Doses of Siponimod (BAF312) on Cardiac Repolarization in Healthy Subjects

作者：Kasra Shakeri-Nejad ; MD¹ ; ^{kasra.shakeri-nejad@novartis.com" class="auth_mail" title="E-mail the corresponding author} ; Vassilios Aslanis ; PharmD¹ ; Uday Kiran Veldandi ; PhD² ; Louise Mooney ; PhD¹ ; Nicole Pezous¹ ; Bruno Brendani¹ ; Axel Juan ; MD³ ; Mark Allison ; MD⁴ ; Robert Perry ; MD⁵ ; Eric Legangneux ; MD¹

关键词：BAF312 ; cardiac repolarization ; healthy subjects ; moxifloxacin ; siponimod ; thorough QT

刊名：Clinical Therapeutics

出版年：2015

10.Ipragliflozin Does Not Prolong QTc Interval in Healthy Male and Female Subjects: A Phase I Study

作者：Wenhui Zhang ; Ronald Smulders ; Anura Abeyratne ; Albert Dietz ; Walter Krauwinkel ; Takeshi Kadokura ; James Keirns

关键词：cardiac repolarization ; diabetes ; ipragliflozin ; Phase 1 ; QTc interval prolongation ; SGLT2 inhibition

刊名：Clinical Therapeutics

出版年：2013

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