搜索页_+intrinsic+hepatic+clearance

常用资源

电子图书

期刊论文

学位会议

在“Elsevier电子期刊”中，命中：75条，耗时：0.0160251 秒

在所有数据库中总计命中：278条

1.New IVIVE method for the prediction of total human clearance and relative elimination pathway contributions from in vitro hepatocyte and microsome data

作者：Julia Riede^a ; ^b ; Birk Poller^a ; Ken-ichi Umehara^a ; Jö ; rg Huwyler^b ; Gian Camenisch^a ; ^{gian.camenisch@novartis.com" class="auth_mail" title="E-mail the corresponding author}

关键词：AFE ; average fold error ; CLh ; hepatic clearance ; CLint ; intrinsic clearance ; CLinth ; intrinsic hepatic clearance ; CLint ; met ; intrinsic metabolic clearance ; CLint ; sec ; intrinsic secretory clearance ; CLren ; renal clearance ; CLtot ; total clearance ; CYP ; cytochrome P450 ; ECCCS ; Extended Clearance Concept Classification System ; ECM ; Extended Clearance Model ; fnh ; fraction of hepatic elimination ; fnmet ; fraction of metabolic elimination ; fnren ; fraction of renal elimination ; fnsec ; fraction of biliar

刊名：European Journal of Pharmaceutical Sciences

出版年：2016

2.Estimating the variability in fraction absorbed as a paradigm for informing formulation development in early clinical drug development

作者：Sarit Cohen Rabbie^a ; ^{sarit.rabbie@astrazeneca.com" class="auth_mail" title="E-mail the corresponding author} ; Paul D. Martin^b ; Talia Flanagan^b ; Abdul W. Basit^a ; Joseph F. Standing^c

关键词：F ; Bioavailability ; fa ; fraction absorbed ; fg ; fraction passing the gut wall ; fh ; fraction escaping hepatic metabolism ; GI ; gastrointestinal ; NLME ; nonlinear mixed effect modelling ; IR ; immediate release ; PR ; prolonged release ; ICH ; international conference on harmonisation ; GCP ; good clinical practice ; CLR ; renal clearance ; CLH ; hepatic clearance ; WT ; weight ; FQ ; liver blood flow ; BPR ; blood/plasma ratio ; CLi ; intrinsic clearance ; LV ; liver volume ; ER ; extraction ratio ; FOCE ; first order condit

刊名：European Journal of Pharmaceutical Sciences

出版年：2016

3.QSARs for estimating intrinsic hepatic clearance of organic chemicals in humans

作者：Alessandra Pirovano^a ; ^{a.pirovano@science.ru.nl" class="auth_mail" title="E-mail the corresponding author} ; Stefan Brandmaier^b ; Mark A.J. Huijbregts^a ; Ad M.J. Ragas^a ; ^c ; Karin Veltman^d ; A. Jan Hendriks^a

关键词：Quantitative structure&ndash ; activity relationship ; Biotransformation ; Clearance (CLINT) ; Hepatocytes ; Microsomes

刊名：Environmental Toxicology and Pharmacology

出版年：2016

4.Effects of verapamil on the pharmacokinetics and hepatobiliary disposition of fexofenadine in pigs

作者：Erik Sjö ; gren^a ; ^{erik.sjogren@farmaci.uu.se" class="auth_mail} ; Mikael Hedeland^b ; ^c ; Ulf Bondesson^b ; ^c ; Hans Lennernä ; s^a

关键词：AUC ; area under the concentration-time curve ; Abile ; amount excreted in bile ; Aurine ; amount excreted in urine ; Aprot ; microsomal content ; Atot.I ; total amount of fexofenadine excreted into the jejunal segment ; Atot.urine ; total amount of fexofenadine excreted into the urine ; BP ; blood to plasma volume ratio ; CLbile ; biliary clearance ; CLdif ; bidirectional passive diffusion clearance ; CLeff ; efflux clearance ; CLH ; hepatic clearance ; CLI ; intestinal clearance ; CLint ; metabolic intrinsic clearanc

刊名：European Journal of Pharmaceutical Sciences

出版年：16 June 2014

5.Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design

作者：Li Di ; ^{LI.DI@PFIZER.COM} ; Christopher Keefer ; Dennis O. Scott ; Timothy J. Strelevitz ; George Chang ; Yi-An Bi ; Yurong Lai ; Jonathon Duckworth ; Katherine Fenner ; Matthew D. Troutman ; R. Scott Obach

关键词：Metabolic stability ; Human liver microsomes ; Human hepatocytes ; Intrinsic clearance ; Hepatic transporters ; Drug discovery

刊名：European Journal of Medicinal Chemistry

出版年：2012

6.In vitro metabolism of benzo[a]pyrene and dibenzo[def,p]chrysene in rodent and human hepatic microsomes

作者：S.R. Crowell^a ; ^{susan.crowell@pnnl.gov" class="auth_mail} ; S. Hanson-Drury^a ; D.E. Williams^b ; R.A. Corley^a

关键词：Benzo[a]pyrene ; Dibenzo[def ; p]chrysene ; Michaelis&ndash ; Menten ; VMAX ; KM ; Intrinsic clearance

刊名：Toxicology Letters

出版年：3 July 2014

7.In vitro hepatic microsomal metabolism of meloxicam in koalas (Phascolarctos cinereus), brushtail possums (Trichosurus vulpecula), ringtail possums (Pseudocheirus peregrinus), rats (Rattus norvegicus) and dogs (Canis lupus familiaris)

作者：B. Kimble^a ; K.M. Li^b ; P. Valtchev^c ; D.P. Higgins^a ; M.B. Krockenberger^a ; M. Govendir^a ; ^{merran.govendir@sydney.edu.au" class="auth_mail}

关键词：Marsupials ; Rat ; Dog ; Meloxicam ; Microsome ; Clearance ; Metabolism

刊名：Comparative Biochemistry and Physiology, Part C

出版年：April, 2014

8.Comparative metabolism of benfuracarb in in vitro mammalian hepatic microsomes model and its implications for chemical risk assessment

作者：Khaled Abass ; Petri Reponen ; Sampo Mattila ; Arja Rautio ; Olavi Pelkonen

关键词：Pesticides ; Toxicokinetics ; P450 ; In vitro metabolism ; Risk assessment

刊名：Toxicology Letters

出版年：13 January, 2014

9.Marsdenia tenacissima extract inhibits gefitinib metabolism in vitro by interfering with human hepatic CYP3A4 and CYP2D6 enzymes

作者：Shu-Yan Han ; Hai-Yu Zhao ; Ning Zhou ; Fei Zhou ; Ping-Ping Li

关键词：Marsdenia tenacissima extract (Xiao-Ai-Ping injection) ; Gefitinib ; Cytochrome P450 ; Drug metabolism

刊名：Journal of Ethnopharmacology

出版年：10 January, 2014

10.In vitro intestinal and hepatic metabolism of Di(2-ethylhexyl) phthalate (DEHP) in human and rat

作者：Kyoungju Choi ; ^{kchoi@thehamner.org} ; Hyun Joo ; Jerry L. Campbell Jr. ; Melvin E. Andersen ; Harvey J. Clewell III

关键词：DEHP ; In vitro hepatic metabolism ; In vitro intestinal metabolism ; Human ; Rat ; Intrinsic clearance

刊名：Toxicology in Vitro

出版年：2013

按检索点细分(75)

题名(4)

关键词(7)

文摘(59)

按出版年细分(75)

2027年及以后(2)

2016年(3)

2013年(7)

2012年(5)

2011年(3)

2010年(3)

2009年(5)

2008年(6)

2007年(4)

2006年(5)

2005年(5)

2004年(5)

2003年(5)

2002年(1)

2001年(2)

2000年(1)

2000年及以前(13)

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700