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在“Elsevier电子期刊”中，命中：14条，耗时：0.0199906 秒

在所有数据库中总计命中：217条

1.Alterations in glucose metabolism proteins responsible for the Warburg effect in esophageal squamous cell carcinoma

关键词：Esophageal cancer ; Warburg effect ; Pyruvate kinase M2 ; GLUT-1 ; Hexokinase 2 ; HIF-1α

刊名：Experimental and Molecular Pathology

出版年：2016

2.1-(sulfonyl)-5-(arylsulfonyl)indoline as activators of the tumor cell specific M2 isoform of pyruvate kinase

作者：Avihai Yacovan ; Rachel Ozeri ; Tzofit Kehat ; Sima Mirilashvili ; Daniel Sherman ; Alex Aizikovich ; Alina Shitrit ; Efrat Ben-Zeev ; Nili Schutz ; Osnat Bohana-Kashtan ; Alex ; er Konson ; Vered Behar ; Oren M. Becker

关键词：PKM2 ; Pyruvate kinase ; Cellular metabolism ; Anti-cancer strategies ; Small molecule activators

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

3.PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

作者：William?J. Israelsen ; Talya?L. Dayton ; Shawn?M. Davidson ; Brian?P. Fiske ; Aaron?M. Hosios ; Gary Bellinger ; Jie Li ; Yimin Yu ; Mika Sasaki ; James?W. Horner ; Laura?N. Burga ; Jianxin Xie ; Michael?J. Jurczak ; Ronald?A. DePinho ; Clary?B. Clish ; Tyler Jacks ; Richard?G. Kibbey ; Gerburg?M. Wulf ; Dolores Di?Vizio ; Gordon?B. Mills ; et al.

刊名：Cell

出版年：2013

4.Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators

作者：Chuangxing Guo ; Angelica Linton ; Mehran Jalaie ; Susan Kephart ; Martha Ornelas ; Mason Pairish ; Samantha Greasley ; Paul Richardson ; Karen Maegley ; Michael Hickey ; John Li ; Xin Wu ; Xiaodong Ji ; Zhi Xie

关键词：M2 isoform of pyruvate kinase ; PKM2 ; PKM2 activator ; PKM2 activation ; PKM1 ; Cancer metabolism ; Warburg effect ; Anti-tumor ; Anti-cancer

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2013

5.Optimization and structure-activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents

作者：Nag S. Kumar^a ; Emily A. Amandoron^b ; Artem Cherkasov^b ; ^c ; B. Brett Finlay^d ; ^e ; Huansheng Gong^b ; Linda Jackson^e ; Sukhbir Kaur^b ; Tian Lian^b ; Anne Moreau^a ; ^&dagger ; ; Christophe Labriè ; re^a ; Neil E. Reiner^b ; ^e ; Raymond H. See^b ; ^f ; Natalie C. Strynadka^d ; Lisa Thorson^b ; Edwin W.Y. Wong^a ; Liam Worrall^d ; Roya Zoraghi^b ; Robert N. Young^a ; ^{roberty@sfu.ca} ; ^{robert_young@sfu.ca}

关键词：MRSA ; methicillin-resistant Staphylococcus aureus ; PK ; pyruvate kinase ; MIC ; minimal inhibitory concentration ; VRSA ; vancomycin-resistant Staphylococcus aureus

刊名：Bioorganic and Medicinal Chemistry

出版年：2012

6.Vitamin K₃ and K₅ are inhibitors of tumor pyruvate kinase M2

作者：Jing Chen^a ; ^b ; Zheng Jiang^c ; Beibei Wang^a ; ^b ; Yanguang Wang^c ; Xun Hu^a ; ^b ; ^{huxun@zju.edu.cn}

关键词：Vitamin K3 ; Vitamin K5 ; Pyruvate kinase M2 ; Inhibitor ; Glycolysis

刊名：Cancer Letters

出版年：2012

7.2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

作者：Martin J. ; Walsh^a ; Kyle R. ; Brimacombe^a ; Henrike ; Veith^a ; James M. ; Bougie^a ; Thomas ; Daniel^a ; William ; Leister^a ; Lewis C. ; Cantley^b ; ; ^c ; William J. ; Israelsen^d ; Matthew G. ; Vander Heiden^d ; ; ^e ; Min ; Shen^a ; Douglas S. ; Auld^a ; ; ^&dagger ; ; Craig J. ; Thomas^a ; Matthew B. ; Boxer^a ; ; ^{boxerm@mail.nih.gov}

关键词：PKM2 ; Pyruvate kinase ; Cellular metabolism ; Anti-cancer strategies ; Small molecule activators

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2011

8.Antisense directed against PS-1 gene decreases brain oxidative markers in aged senescence accelerated mice (SAMP8) and reverses learning and memory impairment: A proteomics study

作者：Ada Fiorini ; Rukhsana Sultana ; Sarah F枚rster ; Marzia Perluigi ; Giovanna Cenini ; Chiara Cini ; Jian Cai ; Jon B. Klein ; Susan A. Farr ; Michael L. Niehoff ; John E. Morley ; Vijaya B. Kumar ; D. Allan Butterfield

关键词：AD ; Alzheimer's disease ; MCI ; mild cognitive impairment ; A尾 ; amyloid 尾-peptide ; FAD ; familial Alzheimer's disease ; NFT ; intracellular neurofibrillary tangles ; APP ; amyloid precursor protein ; PS-1 ; presenilin-1 ; PS-2 ; presenilin-2 ; AO ; antisense oligonucleotide ; SAM ; senescence accelerated mouse ; BCIP/NBT ; 5-bromo-4-chloro-3-indolyl phosphate/nitrotetrazolium blue chloride ; NAD ; isocitrate dehydrogenase ; NAD ; IDH3A ; isocitrate dehydrogenase subunit alpha ; M1/M2 KPYM ; isoform M1 pyruvate kinase

刊名：Free Radical Biology and Medicine

出版年：December, 2013

9.Identification of small molecule inhibitors of pyruvate kinase M2

作者：Matthew G. V ; er Heiden ; Heather R. Christofk ; Eli Schuman ; Alex ; er O. Subtelny ; Hadar Sharfi ; Edward E. Harlow ; Jun Xian ; Lewis C. Cantley

关键词：Pyruvate kinase M2 ; Glycolysis ; Cellular metabolism ; Small molecule inhibitors ; High-throughput screening

刊名：Biochemical Pharmacology

出版年：2010

10.Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

作者：Jian-kang Jiang ; Matthew B. Boxer ; Matthew G. V ; er Heiden ; Min Shen ; Am ; a P. Skoumbourdis ; Noel Southall ; Henrike Veith ; William Leister ; Christopher P. Austin ; Hee Won Park ; James Inglese ; Lewis C. C

关键词：Warburg effect ; Pyruvate kinase ; Cellular metabolism ; Anti-cancer strategies ; Small molecule activators

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2010

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