搜索页_AKT+kinase+inhibitors

常用资源

电子图书

期刊论文

学位会议

在“Elsevier电子期刊”中，命中：1,080条，耗时：0.028984 秒

在所有数据库中总计命中：11,956条

1.Class I phosphatidylinositol 3-kinase inhibitors for cancer therapy

作者：Wennan Zhao^&dagger ; ; Yuling Qiu^&dagger ; ; Dexin Kong ; ^{kongdexin@tmu.edu.cn}

关键词：Phosphatidylinositol 3-kinase ; PI3K inhibitor ; Drug candidate ; Cancer therapy ; PI3K/mTOR selectivity ; Anticancer

刊名：Acta Pharmaceutica Sinica B

出版年：2017

2.Agastache rugosa Kuntze extract, containing the active component rosmarinic acid, prevents atherosclerosis through up-regulation of the cyclin-dependent kinase inhibitors p21^WAF1/CIP1 and p27^KIP1

作者：Jung-Jin Lee^a ; ^{mhjj3998@kiom.re.kr} ; Ji-Hye Lee^a ; ^{ideal0723@kiom.re.kr} ; Min Jung Gu^a ; ^{guminjung@kiom.re.kr} ; Joo-Hui Han^b ; ^{han5621@cnu.ac.kr} ; Won-Kyung Cho^a ; ^{wkcho@kiom.re.kr} ; Jin Yeul Ma^a ; ^{jyma@kiom.re.kr}

关键词：AKT ; phosphatidylinositol 3-kinase-linked protein kinase ; A.rugose ; Agastacherugosa Kuntze ; BrdU ; bromodeoxyuridine ; CA ; caffeic acid ; CCK-8 ; cell counting Kit-8 ; CDK ; cyclin-dependent kinase ; CKI ; cyclin-dependent kinase inhibitor ; DAD ; diode array UV/VIS detector ; DMEM ; Dulbecco&rsquo ; s modified Eagle&rsquo ; s medium ; ERK ; extracellular signal regulated kinase 1/2 ; FBS ; fetal bovine serum ; HPLC ; high-performance liquid chromatographic ; JNK ; c-Jun N-terminal kinase ; PBS ; phosphate-buffered salin

刊名：Journal of Functional Foods

出版年：2017

3.SAR study of 5-alkynyl substituted quinazolin-4(3H)-ones as phosphoinositide 3-kinase delta (PI3Kδ) inhibitors

作者：Manman Wei^a ; ^c ; ¹ ; Xi Zhang^b ; ¹ ; Xiang Wang^b ; Zilan Song^a ; Jian Ding^b ; Ling-Hua Meng^b ; ^{lhmeng@simm.ac.cn} ; Ao Zhang^a ; ^c ; ^{aozhang@simm.ac.cn}

关键词：Chronic lymphocytic leukemia ; PI3Kδ ; Structure-activity relationship ; 5-Alkynyl ; Quinazolinone

刊名：European Journal of Medicinal Chemistry

出版年：2017

4.Long noncoding RNA HULC promotes cell proliferation by regulating PI3K/AKT signaling pathway in chronic myeloid leukemia

作者：Yinghao Lu ^{Yinghaolu123@163.com} ; Yan Li ^{Yanlimed@126.com} ; Xiao Chai ^{xiaochaixc@yeah.net} ; Qian Kang ^{qiankang1@outlook.com} ; Peng Zhao ^{pengzhao-1@outlook.com} ; Jie Xiong ^{jiexiong_vip@21CN.com} ; Jishi Wang ; ^{Jishiwangedu@outlook.com}

关键词：CML ; chronic myeloid leukemia ; TKIs ; tyrosine kinase inhibitors ; lncRNAs ; long non-coding RNAs ; HCC ; hepatocellular carcinoma ; HOX transcript antisense RNA ; HOTAIR M1 ; FBS ; fetal bovine serum ; FITC ; fluorescein isothiocyanate ; shRNA ; short hairpin RNA ; qRT-PCR ; quantitative real time PCR ; CP ; chronic phase ; AP ; accelerate phase ; BP ; blast phase

刊名：Gene

出版年：2017

5.Hyaluronan carried by tumor-derived microvesicles induces IL-10 production in classical (CD14⁺⁺CD16⁻) monocytes via PI3K/Akt/mTOR-dependent signalling pathway

作者：Marzena Lenart^a ; Magdalena Rutkowska-Zapala^a ; Monika Baj-Krzyworzeka^a ; Rafał Szatanek^a ; Kazimierz Węglarczyk^a ; Timothy Smallie^b ; Lö ; ms Ziegler-Heitbrock^c ; ^d ; Marek Zembala^a ; Maciej Siedlar^a ; ^{misiedla@cyf-kr.edu.pl" class="auth_mail" title="E-mail the corresponding author}

关键词：DCs ; dendritic cells ; HA ; hyaluronan ; IRF ; interferon regulatory factor ; MOI ; multiplicity of infection ; PKB ; protein kinase B ; RNI ; reactive nitrogen intermediates ; ROI ; reactive oxygen species ; mTOR ; mammalian target of rapamycin ; TIM ; tumor-infiltrating monocytes/macrophages ; TMV ; tumor microvesicles

刊名：Immunobiology

出版年：2017

6.Kinetic modelling of in vitro data of PI3K, mTOR1, PTEN enzymes and on-target inhibitors Rapamycin, BEZ235, and LY294002

作者：Alexey Goltsov^a ; ^{a.goltsov@abertay.ac.uk} ; Ghassan Tashkandi^b ; ^{s1163633@exseed.ed.ac.uk} ; Simon P. Langdon^b ; ^{Simon.Langdon@ed.ac.uk} ; David J. Harrison^c ; ^{David.Harrison@st-andrews.ac.uk} ; James L. Bown^a ; ^d ; ^{j.bown@abertay.ac.uk}

关键词：Kinetic modelling ; PI3K ; mTOR1 ; PTEN ; Rapamycin ; BEZ235

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

7.miR-200c enhances sensitivity of drug-resistant non-small cell lung cancer to gefitinib by suppression of PI3K/Akt signaling pathway and inhibites cell migration via targeting ZEB1

作者：Guohua Zhou^a ; Fangli Zhang^a ; Yu Guo^a ; Jianfei Huang^a ; Yaqiong Xie^a ; Shuanglei Yue^a ; Minghui Chen^a ; Hao Jiang^b ; Mengjie Li^c ; ^{522237197@qq.com}

关键词：miR-200c ; Drug-resistance ; NSCLC ; PI3K

刊名：Biomedicine & Pharmacotherapy

出版年：2017

8.Apelin protects against NMDA-induced retinal neuronal death via an APJ receptor by activating Akt and ERK1/2, and suppressing TNF-α expression in mice

作者：Yuki Ishimaru ; ¹ ; ^{ishimaru@pharm.setsunan.ac.jp} ; Akihide Sumino¹ ; Daiki Kajioka ; Fumiya Shibagaki ; Akiko Yamamuro ; Yasuhiro Yoshioka ; Sadaaki Maeda ; ^{smaeda@pharm.setsunan.ac.jp}

关键词：Apelin ; APJ ; Knockout mouse ; Neuroprotection ; Retina

刊名：Journal of Pharmacological Sciences

出版年：2017

9.Augmented O-GlcNAc signaling via glucosamine attenuates oxidative stress and apoptosis following contrast-induced acute kidney injury in rats

作者：Jiachang Hu^a ; ^b ; ^c ; ^d ; ¹ ; Rongyi Chen^a ; ^b ; ^c ; ^d ; ¹ ; Ping Jia^a ; ^b ; ^c ; ^d ; Yi Fang^a ; ^b ; ^c ; ^d ; Tongqiang Liu^e ; Nana Song^a ; ^b ; ^c ; ^d ; Xialian Xu^a ; ^b ; ^c ; ^d ; Jun Ji^a ; ^b ; ^c ; ^d ; ^{ji.jun@zs-hospital.sh.cn} ; Xiaoqiang Ding^a ; ^b ; ^c ; ^d ; ^{ding.xiaoqiang@zs-hospital.sh.cn}

关键词：Acute kidney injury ; Iodinated contrast media ; Hexosamine biosynthetic pathway ; Glycogen synthase kinase-3β

刊名：Free Radical Biology and Medicine

出版年：2017

10.cGMP Signaling Increases Antioxidant Gene Expression by Activating Forkhead Box O3A in the Colon Epithelium

作者：Rui Wang^&lowast ; ; Bianca N. Islam^&lowast ; ; Allison Bridges^&lowast ; ; Sarah K. Sharman^&lowast ; ; Muhan Hu^&lowast ; ; Yali Hou^&lowast ; ; Payaningal R. Somanath^&dagger ; ; Laine Venable^&lowast ; ; Nagendra Singh^&lowast ; ; Sangmi Kim^&lowast ; ; Subbaramiah Sridhar^&Dagger ; ; Franz Hofmann^§ ; ; Darren D. Browning^&lowast ; ; ^{dbrowning@augusta.edu}

刊名：The American Journal of Pathology

出版年：2017

按检索点细分(1080)

题名(16)

关键词(23)

文摘(895)

按出版年细分(1080)

2027年及以后(50)

2017年(10)

2016年(40)

2015年(19)

2014年(2)

2013年(101)

2012年(109)

2011年(101)

2010年(96)

2009年(82)

2008年(98)

2007年(89)

2006年(79)

2005年(49)

2004年(45)

2003年(39)

2002年(20)

2001年(12)

2000年(10)

2000年及以前(29)

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700