作者：Mathieu Vinken^a ; ^{mvinken@vub.ac.be} ; Bas J. Blaauboer^b

关键词：AO(P) ; adverse outcome (pathway) ; ATP ; adenosine triphosphate ; DMSO ; dimethylsulfoxide ; DNA ; deoxyribonucleic acid ; KE ; key event ; LDH ; lactate dehydrogenase ; MIE ; molecular initiating event ; MTP ; mitochondrial permeability transition ; MTT ; [3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-diphenyltetrazolium bromide] ; NADH ; nicotinamide adenine dinucleotide

刊名：Toxicology in Vitro

出版年：2017

作者：Beate I. Escher^a ; ¹ ; ^{beate.escher@ufz.de} ; Jö ; rg Hackermü ; ller^a ; ¹ ; Tobias Polte^a ; ¹ ; Stefan Scholz^a ; ¹ ; Achim Aigner^b ; Rolf Altenburger^a ; Alexander Bö ; hme^a ; Stephanie K. Bopp^c ; Werner Brack^a ; Wibke Busch^a ; Marc Chadeau-Hyam^d ; Adrian Covaci^e ; Adolf Eisenträ ; ger^f ; James J. Galligan^g ; Natalia Garcia-Reyero^h ; ⁱ ; Thomas Hartung^j ; ^k ; Michaela Hein^a ; Gunda Herberth^a ; Annika Jahnke^a ; Jos Kleinjans^l ; Nils Klü ; ver^a ; Martin Krauss^a ; Marja Lamoree^m ; Irina Lehmann^a ; Till Luckenbach^a ; Gary W. Millerⁿ ; Andrea Mü ; ller^a ; David H. Phillips^o ; Thorsten Reemtsma^a ; Ulrike Rolle-Kampczyk^a ; Gerrit Schü ; ü ; rmann^a ; ^p ; Benno Schwikowski^q ; Yu-Mei Tan^r ; Saskia Trump^a ; Susanne Walter-Rohde^f ; John F. Wambaugh^s

关键词：AEP ; Aggregate exposure pathway ; AO ; Adverse outcome ; AOP ; adverse outcome pathway ; EWAS ; exposome-wide association studies ; KE ; key event ; HTS ; high throughput screening ; MIE ; molecular initiating event ; TD ; toxicodynamic ; TK ; toxicokinetic

刊名：Environment International

出版年：2017

作者：Satomi Onoue^a ; ^{onoue@u-shizuoka-ken.ac.jp}Author Vitae ; Yoshiki Seto^a ; Hideyuki Sato^a ; Hayato Nishida^b ; Morihiko Hirota^b ; Takao Ashikaga^b ; Anne Marie Api^c ; David Basketter^d ; Yoshiki Tokura^e

关键词：3T3 NRU PT ; 3T3 neutral red uptake phototoxicity testing ; AOP ; adverse outcome pathway ; DEREK ; deductive estimation of risk from existing knowledge ; HOMO-LUMO gap ; energy gap between the highest occupied molecular orbital and the lowest unoccupied molecular orbital ; ICH ; International Council for Harmonization of Technical Requirements for Pharmaceuticals for human use ; IFRA ; International Fragrance Association ; LLNA ; local lymph node assay ; MEC ; molar extinction coefficient ; mROS assay ; micella

刊名：Journal of Dermatological Science

出版年：2017

作者：Guozhu Zhang^a ; ^{gzhang6@ncsu.edu} ; Kyle R. Roell^a ; ^{krroell@ncsu.edu} ; Lisa Truong^c ; ^{lisa.truong@oregonstate.edu} ; Robert L. Tanguay^c ; ^{robert.tanguay@oregonstate.edu} ; David M. Reif^a ; ^b ; ^{dmreif@ncsu.edu}

关键词：AC50 ; half-maximal activity concentration ; AOP ; Adverse Outcome Pathway ; AggE ; Aggregate Entropy ; EZ ; embryonic zebrafish ; HTS ; high-throughput screening ; Hpf ; hours post fertilization ; LD50 ; 50% lethal dose ; MoA ; mechanisms of action ; POD ; point of departure ; ROC ; Receiver Operating Characteristic ; ToxRefDB ; Toxicity Reference Database ; wAggE ; weighted Aggregate Entropy ; TN ; true negative ; TP ; true positive ; FN ; false negative ; FP ; false negative ; MORT ; mortality ; YSE ; yolk sac edema ; AXIS ; bod

刊名：Toxicology and Applied Pharmacology

出版年：2017

作者：Noffisat O. Oki^a ; ^{oki.noffisat@epa.gov" class="auth_mail" title="E-mail the corresponding author} ; Stephen W. Edwards^b ; ^{edwards.stephen@epa.gov" class="auth_mail" title="E-mail the corresponding author}

关键词：AOP ; adverse outcome pathway ; AOP-KB ; adverse outcome pathway knowledgebase ; cpAOP ; computationally predicted adverse outcome pathway ; CTD ; comparative toxicogenomics database ; DAVID ; database for annotation ; visualization and integrated discovery ; ECHA ; european chemicals agency ; FIM ; frequent itemset mining ; HTS ; high throughput screening ; KEGG ; Kyoto encyclopedia of genes and genomes ; MeSH ; medical subject headings ; OECD ; Organization for Economic Cooperation and Development

刊名：Toxicology

出版年：2016

作者：Zachary A. Collier^a ; ^{zac4nf@virginia.edu" class="auth_mail" title="E-mail the corresponding author} ; Kurt A. Gust^a ; Benette Gonzalez-Morales^b ; Ping Gong^a ; Mitchell S. Wilbanks^a ; Igor Linkov^a ; Edward J. Perkins^a

关键词：Adverse outcome pathway ; Weight of evidence ; Quantitative AOP ; Molecular initiating event ; Mode of action ; Key event relationships ; Bradford Hill criteria

刊名：Regulatory Toxicology and Pharmacology

出版年：2016

作者：Lihua Yang^a ; Bingsheng Zhou^a ; Jinmiao Zha^b ; ^c ; ^{jinmiaozha@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; ^{jmzha@rcees.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Zijian Wang^d

关键词：Chlordecone ; Chinese rare minnow (Gobiocypris rarus) ; Endocrine disruption ; Adverse outcome pathway (AOP)

刊名：Chemosphere

出版年：2016

作者：Nicole C. Kleinstreuer^a ; ^{Nicole.kleinstreuer@nih.gov" class="auth_mail" title="E-mail the corresponding author} ; Kristie Sullivan^b ; David Allen^c ; Stephen Edwards^d ; Donna L. Mendrick^e ; Michelle Embry^f ; Joanna Matheson^g ; J. Craig Rowlands^h ; Sharon Munnⁱ ; Elizabeth Maull^a ; Warren Casey^a

关键词：AOP ; Workshop ; Toxicology ; Pathway ; Regulatory ; Quantitative ; Application ; Acceptance ; Criteria ; Computational

刊名：Regulatory Toxicology and Pharmacology

出版年：2016

作者：John P. Incardona ; ^{John.Incardona@noaa.gov" class="auth_mail" title="E-mail the corresponding author} ; Nathaniel L. Scholz

关键词：Embryo ; Larvae ; Polycyclic aromatic hydrocarbon ; PAH ; Oil spill ; Heart ; Zebrafish ; Salmon ; Herring ; Tuna

刊名：Aquatic Toxicology

出版年：2016

作者：D.S. Wikoff^a ; ^{dwikoff@toxstrategies.com" class="auth_mail" title="E-mail the corresponding author} ; J.E. Rager^a ; L.C. Haws^a ; S.J. Borghoff^b

关键词：TBBPA ; AOP ; Estrogen ; Sulfotransferase ; Mode of action ; Uterine tumor

刊名：Regulatory Toxicology and Pharmacology

出版年：2016