搜索页_Heat shock protein 90 (Hsp 90)

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1.Virtual screening and biophysical studies lead to HSP90 inhibitors

作者：Renjie Huang ; Daniel M. Ayine-Tora ; M. Nasri Muhammad Rosdi ; Yu Li ; Jó ; hannes Reynisson ; ^{j.reynisson@auckland.ac.nz} ; Ivanhoe K.H. Leung ; ^{i.leung@auckland.ac.nz}

关键词：17-AAG ; 17-allylamino-17-demethoxygeldanamycin ; 17-DMAG ; 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG) ; ADP ; adenosine diphosphate ; AMPPCP ; 5&prime ; -adenylylmethylenediphosphonate ; ASP ; Astex statistical potential ; ATP ; adenosine triphosphate ; CS ; ChemScore ; GS ; GoldScore ; HB ; hydrogen bonding ; HSP90 ; heat shock protein 90 ; HSQC ; heteronuclear single quantum correlation ; KD ; binding affinity ; ND ; N-domain ; NMR ; nuclear magnetic resonance ; NOE ; nuclear Overhauser effect ; Tm ; pro

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

2.Design, synthesis and pharmacological evaluation of 4,5-diarylisoxazols bearing amino acid residues within the 3-amido motif as potent heat shock protein 90 (Hsp90) inhibitors

作者：Chi Zhang^a ; ^c ; ¹ ; Xin Wang^b ; ^d ; ¹ ; Hongchun Liu^b ; Minmin Zhang^b ; Meiyu Geng^b ; Liping Sun^a ; ^{chslp@cpu.edu.cn} ; Aijun Shen^b ; ^{shenaj@simm.ac.cn} ; Ao Zhang^c ; ^{aozhang@simm.ac.cn}

关键词：Diarylisoxazole ; Resorcinol ; Amino acid ; Hsp90 inhibitor ; Antiproliferative effect

刊名：European Journal of Medicinal Chemistry

出版年：2017

3.C0818, a novel curcumin derivative, interacts with Hsp90 and inhibits Hsp90 ATPase activity

作者：Yingjuan Fan^a ; ^b ; Yang Liu^a ; ^b ; Lianru Zhang^c ; Fang Cai^a ; ^b ; Liping Zhu^a ; ^b ; Jianhua Xu^a ; ^b ; ^{xjh@mail.fjmu.edu.cn}

关键词：Curcumin derivative ; Hsp90 ; ATPase activity ; Fluorescence spectrometry ; Interaction

刊名：Acta Pharmaceutica Sinica B

出版年：2017

4.HSP70 and HSP90 are involved in shrimp Penaeus vannamei tolerance to AHPND-causing strain of Vibrio parahaemolyticus after non-lethal heat shock

作者：Wisarut Junprung^a ; Premruethai Supungul^b ; Anchalee Tassanakajon^a ; ^{anchalee.k@chula.ac.th}

关键词：Heat shock protein ; Penaeus vannamei ; Vibrio parahaemolyticus ; Acute hepatopancreatic necrosis disease ; Chronic heat stress

刊名：Fish & Shellfish Immunology

出版年：2017

5.Design, synthesis and biological evaluation of 7-(aryl)-2,3-dihydro-[1,4]dioxino[2,3-g]quinoline derivatives as potential Hsp90 inhibitors and anticancer agents

作者：Sina Omid Malayeri^a ; ^b ; Khalil Abnous^c ; Atefeh Arab^d ; Maryam Akaberi^e ; Soghra Mehri^c ; Afshin Zarghi^f ; Razieh Ghodsi^a ; ^b ; ^{ghodsir@mums.ac.ir}

关键词：Quinolines ; Heat Shock Protein 90 ; Anti-cancer activity ; Her2 ; Molecular docking ; Hsp90 inhibitor

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

6.Design, synthesis and biological evaluation of alkylamino biphenylamides as Hsp90 C-terminal inhibitors

作者：Gaurav Garg ; Huiping Zhao ; Brian S.J. Blagg ; ^{bblagg@ku.edu}

关键词：Heat shock protein 90 ; Hsp90 C-terminal inhibitors ; Alkylamino biphenylamides ; Structure-activity relationship ; Breast cancer

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

7.Inhibition of heat shock protein (Hsp) 90 potentiates the antiproliferative and pro-apoptotic effects of 2-(4′fluoro-phenylamino)-4H-1,3-thiazine[6,5-b]indole in A2780cis cells

作者：Zuzana Solá ; rová ; ^a ; Martin Kello^a ; Lenka Varinská ; ^a ; Mariana Budovská ; ^b ; Peter Solá ; r^c ; ^{peter.solar@upjs.sk}

关键词：thiazine[6 ; 5-b]indole ; 2-(4&prime ; fluoro-phenylamino)-4H-1 ; 3-thiazine[6 ; 5-b]indole ; Hsp ; heat shock protein ; 17-DMAG ; 17-dimethylaminoethylamino-17-demethoxygeldanamycin ; 17-AAG ; 17-(allylamino)-17-demethoxygeldanamycin ; A2780 ; human ovarian adenocarcinoma cell line ; A2780cis ; human ovarian adenocarcinoma cell line resistant to cisplatin ; PARP ; poly (ADP-ribose) polymerase ; MMP ; mitochondrial membrane potential ; An ; annexin ; PI ; propidium iodide

刊名：Biomedicine & Pharmacotherapy

出版年：2017

8.Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors

作者：Ju-Hyeon Lee^a ; ^c ; ¹ ; Sang Chul Shin^b ; ^d ; ¹ ; Seon Hee Seo^a ; Young Ho Seo^e ; Nakcheol Jeong^c ; Chan-Wha Kim^d ; Eunice EunKyeong Kim^b ; ^{eunice@kist.re.kr} ; Gyochang Keum^a ; ^{gkeum@kist.re.kr}

关键词：Hsp90 ; Structure-based design ; Cancer ; Antiproliferative ; Pyrrolo[2 ; 3-d]pyrimidines

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

9.CD30 Induces Heat Shock Protein 90 and Signal Integration in Classic Hodgkin Lymphoma Cells

作者：Mariko Watanabe^&lowast ; ; Kazumi Nakano^&dagger ; ; Marshall E. Kadin^&Dagger ; ; Masaaki Higashihara^&lowast ; ; Toshiki Watanabe^&dagger ; ; Ryouichi Horie^&lowast ; ; ^§ ; ; ^{rhorie@med.kitasato-u.ac.jp}

刊名：The American Journal of Pathology

出版年：2017

10.Defining the Na⁺/H⁺ exchanger NHE1 interactome in triple-negative breast cancer cells

作者：Schammim Ray Amith^a ; ¹ ; ^{s.r.amith@keele.ac.uk} ; Krista Marie Vincent^b ; ^c ; ^{kvincent@ualberta.ca} ; Jodi Marie Wilkinson^a ; ^{jmwilkin@ualberta.ca} ; Lynne Marie Postovit^b ; ^{postovit@ualberta.ca} ; Larry Fliegel^a ; ^{lfliegel@ualberta.ca}

关键词：ACC1 ; acetyl-CoA carboxylase ; AKT ; protein kinase B ; PKB ; CAII ; carbonic anhydrase II ; CHP1 ; calcineurin B homologous protein 1 ; ER ; estrogen receptor ; ERK1/2 ; extracellular signal-regulated kinase 1/2 ; ERM ; ezrin-radixin-moesin ; FOXO3a ; forkhead box O3a ; GSK ; glycogen synthase kinase ; HA ; hemagglutinin ; HER2 ; human epidermal growth factor receptor 2 ; HSP70/HSP90 ; heat shock protein70/90 ; p38MAPK ; p38 mitogen-activated protein kinases ; NF2 ; neurofibromin 2 ; NHE1 ; Na+/H+ exchanger isoform 1 ; PDGF

刊名：Cellular Signalling

出版年：2017

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