作者：Clara Lubeseder-Martellato^a ; ^{clara.lubeseder-martellato@tum.de} ; Katharina Alexandrow^a ; Ana Hidalgo-Sastre^a ; Irina Heid^b ; Sophie Luise Boos^a ; ^c ; Thomas Briel^a ; Roland M. Schmid^a ; ^c ; Jens T. Siveke^a ; ^c ; ^d ; ^{j.siveke@dkfz.de}

关键词：Oncogenic KRas ; Fluid-phase endocytosis ; Pancreatic ductal adenocarcinoma (PDAC) ; Acinar-to-ductal metaplasia (ADM) ; Acinar epithelial explants ; Neural-Wiskott-Aldrich syndrome protein (N-WASP) ; Mice models

刊名：EBioMedicine

出版年：2017

作者：Junichi Matsuo¹ ; ^&lowast ; ; Shunichi Kimura¹ ; ² ; ^&lowast ; ; Akihiro Yamamura¹ ; ² ; ^&lowast ; ; Cai Ping Koh¹ ; Md Zakir Hossain¹ ; Dede Liana Heng¹ ; Kazuyoshi Kohu¹ ; Dominic Chih-Cheng Voon¹ ; Hiroshi Hiai³ ; Michiaki Unno² ; Jimmy Bok Yan So⁴ ; Feng Zhu⁵ ; Supriya Srivastava¹ ; Ming Teh⁶ ; Khay Guan Yeoh⁵ ; ⁷ ; Motomi Osato¹ ; ⁸ ; ⁹ ; ¹⁰ ; ^{csimo@nus.edu.sg} ; Yoshiaki Ito¹ ; ⁵ ; ^{csiitoy@nus.edu.sg}

关键词：Stomach Cancer ; Mouse Model ; Cancer Stem Cell ; Oncogene

刊名：Gastroenterology

出版年：2017

作者：Chih-Chieh Yu^a ; Wanglong Qiu^a ; Caroline S. Juang^a ; Mahesh M. Mansukhani^b ; Balazs Halmos^c ; Gloria H. Su^a ; ^b ; ^d ; ^{gs2157@columbia.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：MASI ; UPD ; Loss of wild-type allele ; KRAS ; EGFR ; PDAC

刊名：Cancer Letters

出版年：2017

作者：Zheng Wang^&lowast ; ; Gang Cheng^&dagger ; ; Xiaohong Han^&Dagger ; ; Xinlin Mu^§ ; ; Yuhui Zhang^¶ ; ; Di Cui^&lowast ; ; Chang Liu^‖ ; Li Zhang^&lowast ; &lowast ; ; Zaiwen Fan^&dagger ; &dagger ; ; Lingyun Ma^&Dagger ; &Dagger ; ; Li Yang^&lowast ; ; Jing Di^&lowast ; ; David S. Cram^§ ; § ; ; Yuankai Shi^&Dagger ; ; ^{syuankaipumc@126.com} ; Dongge Liu^&lowast ; ; ^{liudongge@sohu.com}

刊名：The Journal of Molecular Diagnostics

出版年：2017

作者：Karen M. Mann^a ; ^{kmmann@houstonmethodist.org} ; Haoqiang Ying^b ; Joseph Juan^c ; Nancy A. Jenkins^a ; Neal G. Copeland^a

关键词：PDAC ; pancreatic ductal adenocarcinoma ; KRAS ; Kirsten rat sarcoma viral oncogene ; GEMM ; genetically engineered mouse model ; SB_PDAC ; Sleeping Beauty insertional mutagenesis model of pancreatic cancer ; GAP ; GTPase activating protein ; GEF ; guanine nucleotide exchange factor ; EGFR ; Epidermal growth factor receptor ; MEK ; mitogen-activated protein kinase kinase ; ERK ; extracellular signal-related kinase ; PI3K ; phosphoinositide 3-kinase

刊名：Pharmacology & Therapeutics

出版年：2016

作者：Sunita Shankar¹ ; ² ; Sethuramasundaram Pitchiaya¹ ; ² ; ³ ; Rohit Malik¹ ; ² ; Vishal Kothari¹ ; ² ; Yasuyuki Hosono¹ ; ² ; Anastasia K. Yocum¹ ; ² ; Harika Gundlapalli¹ ; ² ; Yasmine White⁴ ; Ari Firestone⁴ ; Xuhong Cao¹ ; ⁵ ; Saravana M. Dhanasekaran¹ ; ² ; Jeanne A. Stuckey⁶ ; ⁷ ; Gideon Bollag⁸ ; Kevin Shannon⁴ ; Nils G. Walter³ ; Chandan Kumar-Sinha¹ ; ² ; Arul M. Chinnaiyan¹ ; ² ; ⁵ ; ⁹ ; ¹⁰ ; ^{arul@umich.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：cancer ; KRAS ; EIF2C2 ; Argonaute 2 ; RNA silencing

刊名：Cell Reports

出版年：2016

作者：Olga N. Ilinskaya^a ; ¹ ; Indrabahadur Singh^b ; ¹ ; Elena Dudkina^a ; ^{lenatimonina@rambler.ru" class="auth_mail" title="E-mail the corresponding author} ; Vera Ulyanova^a ; Airat Kayumov^a ; Guillermo Barreto^a ; ^b ; ^c ; ^d ; ^{guillermo.barreto@mpi-bn.mpg.de" class="auth_mail" title="E-mail the corresponding author}

关键词：RAS ; Rat sarcoma ; GTPase ; hydrolase enzyme that can bind and hydrolyze guanosine triphosphate (GTP) ; Binase ; Bacillus pumilus ribonuclease ; ERK ; extracellular signal-regulated kinases

刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research

出版年：2016

作者：Ruth Nussinov^a ; ^b ; ^{NussinoR@helix.nih.gov" class="auth_mail" title="E-mail the corresponding author} ; Chung-Jung Tsai^a ; Hyunbum Jang^a ; Tamá ; s Korcsmá ; ros^c ; ^d ; Peter Csermely^e

关键词：YAP1 ; Yes ; MAPK ; mitogen-activated protein kinase ; ERK ; extracellular signal-regulated kinase ; eIF4E ; eukaryotic translation initiation factor 4E ; PI3K ; phosphatidylinositide-3-kinase ; WNT ; Wingless-type mouse mammary tumor virus integration site family member ; GPCRs ; G protein-coupled receptors ; TNF ; tumor necrosis factor ; mTOR ; mammalian target of rapamycin ; TLR ; Toll-like receptor ; JAK ; Janus kinase ; STAT ; signal transducer and activator of transcription ; CDK ; Cyclin-dependent kinase ; pRb ; re

刊名：Seminars in Cell & Developmental Biology

出版年：2016

作者：Yiannis Drosos^* ; Geoffrey Neale^&dagger ; ; Jianming Ye^* ; Leena Paul^* ; Emin Kuliyev^* ; Anirban Maitra^&Dagger ; ; Anna L Means^§ ; ; M Kay Washington^¶ ; ; Jerold Rehg^# ; David B Finkelstein^** ; Beatriz Sosa-Pineda^* ; ^&dagger ; &dagger ; ; ^{beatriz.sosa-pineda@northwestern.edu" class="auth_mail" title="E-mail the corresponding author}

刊名：Neoplasia

出版年：2016

作者：Maria Moksnes Bjaanæ ; s^a ; ^b ; ¹ ; ^{mamok@rr-research.no" class="auth_mail" title="E-mail the corresponding author} ; Thomas Fleischer^a ; ^e ; ¹ ; ^{thomas.fleischer@rr-research.no" class="auth_mail" title="E-mail the corresponding author} ; Ann Rita Halvorsen^a ; ^{Ann.Rita.Halvorsen@rr-research.no" class="auth_mail" title="E-mail the corresponding author} ; Antoine Daunay^h ; ^{antoine.daunay@cephb.fr" class="auth_mail" title="E-mail the corresponding author} ; Florence Busato^g ; ^{busato@cng.fr" class="auth_mail" title="E-mail the corresponding author} ; Steinar Solberg^c ; ^{Steinar.Solberg@oslo-universitetssykehus.no" class="auth_mail" title="E-mail the corresponding author} ; Lars Jø ; rgensen^c ; ^{Lars.Jorgensen@oslo-universitetssykehus.no" class="auth_mail" title="E-mail the corresponding author} ; Elin Kure^a ; ^{Elin.Kure@rr-research.no" class="auth_mail" title="E-mail the corresponding author} ; Hege Edvardsen^a ; ² ; ^{hege.edvardsen@abbvie.com" class="auth_mail" title="E-mail the corresponding author} ; Anne-Lise Bø ; rresen-Dale^a ; ^d ; ^{a.l.borresen-dale@medisin.uio.no" class="auth_mail" title="E-mail the corresponding author} ; Odd Terje Brustugun^a ; ^b ; ^{ot.brustugun@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Jö ; rg Tost^g ; ^{tost@cng.fr" class="auth_mail" title="E-mail the corresponding author} ; Vessela Kristensen^a ; ^e ; ^f ; ^{v.n.kristensen@medisin.uio.no" class="auth_mail" title="E-mail the corresponding author} ; Å ; slaug Helland^a ; ^b ; ^{aslaug.helland@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：DNA methylation ; Lung cancer ; EGFR ; NSCLC ; LUAD ; TP53 ; mRNA ; Adenocarcinoma ; KRAS ; Prognosis ; CpG ; TP53 ; 450K

刊名：Molecular Oncology

出版年：2016