搜索页_Sphingosine+kinase+1+inhibitor

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在“Elsevier电子期刊”中，命中：220条，耗时：0.0249921 秒

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1.Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances

作者：Susan Pyne^a ; ^{susan.pyne@strath.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; David R. Adams^b ; ^{d.r.adams@hw.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Nigel J. Pyne^a ; ^{n.j.pyne@strath.ac.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：Sphingosine 1-phosphate ; Sphingosine kinase ; S1P receptors ; Intracellular signalling ; Sphingosine kinase inhibitors

刊名：Progress in Lipid Research

出版年：2016

2.Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension

作者：Neil MacRitchie^a ; Giora Volpert^b ; Mohammed Al Washih^a ; David G. Watson^a ; Anthony H. Futerman^b ; Simon Kennedy^c ; Susan Pyne^a ; Nigel J. Pyne^a ; ^{n.j.pyne@strath.ac.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：Sphingosine kinase ; Sphingosine 1-phosphate ; Hypoxia ; Pulmonary arterial hypertension ; Hypertrophy ; Vascular remodelling

刊名：Cellular Signalling

出版年：2016

3.Targeting colorectal cancer cells by a novel sphingosine kinase 1 inhibitor PF-543

作者：TongFa Ju^a ; DaQuan Gao^c ; Zheng-yu Fang^b ; ^{fangzhengyu158@sina.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Colorectal cancer ; Sphingosine kinase 1 ; PF-543 ; Programmed necrosis

刊名：Biochemical and Biophysical Research Communications

出版年：2016

4.Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation

作者：Nigel J. Pyne^a ; ^{n.j.pyne@strath.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Melissa McNaughton^a ; Stephanie Boomkamp^a ; Neil MacRitchie^a ; Cecilia Evangelisti^b ; Alberto M. Martelli^b ; Hui-Rong Jiang^a ; Satvir Ubhi^a ; Susan Pyne^a

关键词：ASC ; apoptosis-associated speck-like protein containing a caspase recruitment domain ; DAMPs ; danger associated molecular patterns ; EAE ; experimental autoimmune encephalomyelitis ; HER2 ; human epidermal growth factor related receptor 2 ; ERK ; extracellular signal regulated kinase ; mTOR ; mammalian target of rapamycin ; LPS ; lipopolysaccharide ; NLRP3 ; NOD-like receptor family ; pyrin domain containing 3 ; IFNγ ; interferon gamma ; IL-1β ; interleukin-1beta ; PI3K ; phosphoinositide 3-kinase ; PP2A ; protein ph

刊名：Advances in Biological Regulation

出版年：2016

5.Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions

作者：Ying Yang^a ; Federico Torta^b ; Ken Arai^c ; Markus R. Wenk^b ; ^d ; Deron R. Herr^a ; Peter T.-H. Wong^a ; ^{peter_wong@nuhs.edu.sg" class="auth_mail" title="E-mail the corresponding author} ; Mitchell K.P. Lai^a ; ^{mitchell.lai@dementia-research.org" class="auth_mail" title="E-mail the corresponding author}

关键词：Sphingosine-1-phosphate ; Sphingosine kinase ; Hypoperfusion ; White matter lesions ; Bilateral carotid artery stenosis

刊名：Neurochemistry International

出版年：2016

6.SphK1 inhibitor SKI II inhibits the proliferation of human hepatoma HepG2 cells via the Wnt5A/β-catenin signaling pathway

作者：Hong Liu^a ; Cai-Xia Zhang^a ; Yan Ma^a ; Hong-Wei He^a ; Jia-Ping Wang^b ; Rong-Guang Shao^a ; ^{shaor@imb.pumc.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：SKI II ; Sphingosine kinase ; Wnt signaling pathway ; Wnt5A protein ; Cell proliferation ; Hepatocellular carcinoma

刊名：Life Sciences

出版年：2016

7.Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase 2 and FAK/AKT pathway

作者：Ruxin Zhang^a ; ^b ; Ling Li^b ; Li Yuan^a ; Min Zhao^a ; ^{minzhao0216@163.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Hypoxic preconditioning ; Hypoxia/reoxygenation injury ; Sphingosine kinase 2 ; Apoptosis ; FAK/AKT signaling pathway

刊名：Experimental and Molecular Pathology

出版年：2016

8.Sphingosine-1-phosphate receptor 2 mediates endothelial cells dysfunction by PI3K-Akt pathway under high glucose condition

作者：Weihua Liu^a ; ¹ ; ^{liuweihua.96@163.com" class="auth_mail" title="E-mail the corresponding author} ; Bin Liu^a ; Shaojun Liu^a ; Jingzhi Zhang^a ; Shuangfeng Lin^b ; ^{linshfeng2004@163.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Sphingosine-1-phosphate ; Sphingosine-1-phosphate receptor 2 ; Endothelial cells ; PI3K ; Akt ; Diabetes

刊名：European Journal of Pharmacology

出版年：2016

9.Ceramide 1-phosphate regulates cell migration and invasion of human pancreatic cancer cells

作者：Io-Guané ; Rivera^a ; Marta Ordoñ ; ez^a ; Natalia Presa^a ; Patricia Gangoiti^a ; Ana Gomez-Larrauri^a ; ¹ ; Miguel Trueba^a ; Todd Fox^b ; Mark Kester^b ; Antonio Gomez-Muñ ; oz^a ; ^{antonio.gomez@ehu.es" class="auth_mail" title="E-mail the corresponding author}

关键词：Akt (PKB) ; protein kinase B ; BSA ; bovine serum albumin ; CerK ; ceramide kinase ; C1P ; ceramide 1-phosphate ; DMEM ; Dulbecco&rsquo ; s Modified Eagle&rsquo ; s medium ; ERK ; extracellularly regulated kinases ; FBS ; fetal bovine serum ; MCP-1 ; monocyte/macrophage chemoattractant protein-1 ; MEK ; mitogen activated protein kinase kinase ; mTOR ; mammalian target of rapamycin ; PA ; phosphatidic acid ; Ptx ; pertussis toxin ; PI3K ; phosphatidylinositol 3-kinase ; ROCK ; Rho-associated protein Kinase ; S1P ; sphingosine 1-

刊名：Biochemical Pharmacology

出版年：2016

10.The ceramide inhibitor fumonisin B1 mitigates the pulmonary effects of low-dose diesel exhaust inhalation in mice

关键词：DE ; diesel exhaust ; DEP ; diesel exhaust particles ; PBS ; phosphate-buffered saline ; PM ; particulate matter ; ROS ; reactive oxygen species ; S1P ; sphingosine-1-phosphate ; SP ; surfactant protein ; SphK1 ; sphingosine kinase 1

刊名：Ecotoxicology and Environmental Safety

出版年：2016

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