作者：Dong-Hwan Kim (1)
Alexander Jahn (1)
Sung-Joon Cho (1)
Jung Sun Kim (2)
Min-Hyo Ki (3)
Dae-Duk Kim (1)

1. College of Pharmacy and Research Institute of Pharmaceutical Science ; Seoul National University ; Seoul ; 151-742 ; Republic of Korea
2. Division of Health Sciences ; Dongseo University ; Busan ; 617-716 ; Republic of Korea
3. Chong Kun Dang Research Institute ; CKD Pharmaceutics Inc. ; 464-3 Jung-dong ; Giheung-gu ; Yongin-si ; Gyeonggi-Do ; 446-916 ; Republic of Korea

关键词：Drug delivery ; Liquid crystals ; Cubosome ; Hexosome

刊名：Journal of Pharmaceutical Investigation

出版年：2015

作者：Shakti Mehrotra (1)
Manoj K. Goel (1) (2)
Vikas Srivastava (1) (3)
Laiq Ur Rahman (1)

1. Plant Biotechnology Division ; Central Institute of Medicinal and Aromatic Plants ; P.O. CIMAP ; Picnic spot Road ; Lucknow ; 226015 ; India
2. BioSeed Research India Limited ; ICRISAT ; Patancheru ; 502324 ; Hyderabad ; India
3. National Institute of Plant Genome Research ; Aruna Asaf Ali Road ; P. O. Box 10531 ; New Delhi ; 110 067 ; India

关键词：Bioreactor ; Hairy root cultures ; In vitro preservation ; Pathway engineering ; Rauwolfia ; Terpenoid indole alkaloids

刊名：Biotechnology Letters

出版年：2015

作者：Toshiaki Watanabe (1)
Michio Itabashi (2)
Yasuhiro Shimada (3)
Shinji Tanaka (4)
Yoshinori Ito (5)
Yoichi Ajioka (6)
Tetsuya Hamaguchi (3)
Ichinosuke Hyodo (7)
Masahiro Igarashi (8)
Hideyuki Ishida (9)
Soichiro Ishihara (1)
Megumi Ishiguro (10)
Yukihide Kanemitsu (11)
Norihiro Kokudo (12)
Kei Muro (13)
Atsushi Ochiai (14)
Masahiko Oguchi (15)
Yasuo Ohkura (16)
Yutaka Saito (17)
Yoshiharu Sakai (18)
Hideki Ueno (19)
Takayuki Yoshino (20)
Narikazu Boku (21)
Takahiro Fujimori (22)
Nobuo Koinuma (23)
Takayuki Morita (24)
Genichi Nishimura (25)
Yuh Sakata (26)
Keiichi Takahashi (27)
Osamu Tsuruta (28)
Toshiharu Yamaguchi (29)
Masahiro Yoshida (30)
Naohiko Yamaguchi (31)
Kenjiro Kotake (32)
Kenichi Sugihara (10)
Japanese Society for Cancer of the Colon and Rectum

1. Department of Surgical Oncology ; Graduate School of Medicine ; The University of Tokyo ; 7-3-1 Hongo ; Bunkyo-ku ; Tokyo ; 113-8655 ; Japan
2. Department of Surgery 2 ; Tokyo Women鈥檚 Medical University ; Tokyo ; Japan
3. Division of Gastrointestinal Medical Oncology ; National Cancer Center Hospital ; Tokyo ; Japan
4. Department of Endoscopy ; Hiroshima University Hospital ; Hiroshima ; Japan
5. Department of Radiation Oncology ; National Cancer Center Hospital ; Tokyo ; Japan
6. Division of Molecular and Diagnostic Pathology ; Graduate School of Medical and Dental Sciences ; Niigata University ; Niigata ; Japan
7. Division of Gastroenterology ; Graduate School of Comprehensive Human Sciences ; University of Tsukuba ; Ibaraki ; Japan
8. Department of Endoscopy ; The Cancer Institute Hospital ; Japanese Foundation for Cancer Research ; Tokyo ; Japan
9. Department of Digestive Tract and General Surgery ; Saitama Medical Center ; Saitama Medical University ; Saitama ; Japan
10. Department of Surgical Oncology ; Graduate School ; Tokyo Medical and Dental University ; Tokyo ; Japan
11. Colorectal Surgery Division ; National Cancer Center Hospital ; Tokyo ; Japan
12. Hepato-Biliary-Pancreatic Surgery Division ; Artificial Organ and Transplantation Division ; Department of Surgery ; Graduate School of Medicine ; The University of Tokyo ; Tokyo ; Japan
13. Department of Clinical Oncology ; Aichi Cancer Center Hospital ; Nagoya ; Japan
14. Pathology Division ; Research Center for Innovative Oncology ; National Cancer Centre Hospital East ; Chiba ; Japan
15. Radiation Oncology Department ; The Cancer Institute Hospital ; Japanese Foundation for Cancer Research ; Tokyo ; Japan
16. Department of Pathology ; Kyorin University School of Medicine ; Tokyo ; Japan
17. Endoscopy Division ; National Cancer Center Hospital ; Tokyo ; Japan
18. Department of Surgery ; Kyoto University ; Kyoto ; Japan
19. Department of Surgery ; National Defense Medical College ; Saitama ; Japan
20. Department of Gastroenterology and Gastrointestinal Oncology ; National Cancer Center Hospital East ; Chiba ; Japan
21. Department of Clinical Oncology ; St. Marianna University ; Kawasaki ; Japan
22. Department of Surgical and Molecular Pathology ; Dokkyo Medical University School of Medicine ; Tochigi ; Japan
23. Department of Health Administration and Policy ; Tohoku Pharmaceutical University ; Miyagi ; Japan
24. Department of Surgery ; Cancer Center ; Aomori Prefectural Central Hospital ; Aomori ; Japan
25. Department of Surgery ; Japanese Red Cross Kanazawa Hospital ; Ishikawa ; Japan
26. CEO ; Misawa City Hospital ; Aomori ; Japan
27. Department of Surgery ; Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital ; Tokyo ; Japan
28. Division of GI Endoscopy ; Kurume University School of Medicine ; Fukuoka ; Japan
29. Department of Gastroenterological Surgery ; The Cancer Institute Hospital ; Japanese Foundation for Cancer Research ; Tokyo ; Japan
30. Department of Hemodialysis and Surgery ; Chemotherapy Research Institute ; International University of Health and Welfare ; Chiba ; Japan
31. Library ; Toho University Medical Center Sakura Hospital ; Chiba ; Japan
32. Department of Surgery ; Tochigi Cancer Center ; Tochigi ; Japan

关键词：Colorectal cancer ; Guideline ; Surgery ; Chemotherapy ; Endoscopy ; Radiotherapy

刊名：International Journal of Clinical Oncology

出版年：2015

作者：Maryam Ahmadi (1)
Christine J. Bryson (1) (4)
Edward A. Cloake (1)
Katie Welch (1)
Vasco Filipe (2) (5)
Stefan Romeijn (2)
Andrea Hawe (3)
Wim Jiskoot (2)
Matthew P. Baker (1)
Mark H. Fogg (1)

1. Antitope Ltd ; Babraham Research Campus ; Babraham ; Cambridge ; CB22 3AT ; UK
4. Department of Haematology ; Cambridge University Hospitals ; Hills Road ; Cambridge ; CB2 0QQ ; UK
2. Division of Drug Delivery Technology ; Leiden Academic Centre for Drug Research ; Leiden University ; Leiden ; The Netherlands
5. Adocia ; 115 Avenue Lacassagne ; 69003 ; Lyon ; France
3. Coriolis Pharma ; Am Klopferspitz 19 ; 82152 ; Martinsried ; Germany

关键词：anti ; drug antibodies ; biotherapeutics ; CD4+ T cell responses ; humanized antibodies ; immunogenicity

刊名：Pharmaceutical Research

出版年：2015

作者：Benjamin Weber (1)
Sau L. Lee (2)
Renishkumar Delvadia (3)
Robert Lionberger (3)
Bing V. Li (3)
Yi Tsong (4)
Guenther Hochhaus (1)

1. Department of Pharmaceutics ; College of Pharmacy ; Center of Pharmacometrics and Systems Pharmacology ; University of Florida ; Gainesville ; FL ; USA
2. Office of Pharmaceutical Science ; Center for Drug Evaluation and Research ; Food and Drug Administration ; White Oak Building 51 ; Room 4144 ; 10903 New Hampshire Avenue ; Silver Spring ; MD ; 20993 ; USA
3. Office of Generic Drugs ; Center for Drug Evaluation and Research ; Food and Drug Administration ; Silver Spring ; MD ; USA
4. Division of Biometrics VI ; Office of Biostatistics ; Center for Drug Evaluation and Research ; Food and Drug Administration ; Silver Spring ; MD ; USA

关键词：aerodynamic particle size distribution ; bioequivalence ; cascade impactor ; chi ; square ratio statistic ; orally inhaled drug products

刊名：The AAPS Journal

出版年：2015

作者：Laura K. Hmiel (1)
Kurt A. Brorson (2)
Michael T. Boyne II (1)

1. Center for Drug Evaluation and Research ; Office of Testing and Research ; Division of Pharmaceutical Analysis ; United States Food and Drug Administration ; Saint Louis ; MO ; 63110 ; USA
2. Center for Drug Evaluation and Research ; Office of Biotechnology Products ; Division of Monoclonal Antibodies ; United States Food and Drug Administration ; Silver Spring ; MD ; 20993 ; USA

关键词：IgG ; Post ; translational modifications ; Bioprocess ; Monoclonal antibodies ; Effector function

刊名：Analytical and Bioanalytical Chemistry

出版年：2015

作者：Nagy M. Khalifa (1) (2)
Mohamed A. Al-Omar (1)
Abd El-Galil E. Amr (1) (3)
Ayman R. Baiuomy (4) (5)
Rehab F. Abdel-Rahman (4)

1. Pharmaceutical Chemistry Department ; Drug Exploration & Development Chair (DEDC) ; College of Pharmacy ; King Saud University ; Riyadh ; 11451 ; Saudi Arabia
2. Department of Therapeutical Chemistry ; Pharmaceutical and Drug Industries Division ; National Research Centre ; Dokki ; Cairo ; Dokki ; 12622 ; Egypt
3. Applied Organic Chemistry Department ; National Research Centre ; Cairo ; Dokki ; 12622 ; Egypt
4. Department of Pharmacology ; National Research Centre ; Cairo ; Dokki ; 12622 ; Egypt
5. College of Medicine and Medical Sciences ; Taif University ; Taif ; Saudi Arabia

关键词：thiazolopyrimidine ; Biginelli compounds ; anti ; inflammatory ; analgesic

刊名：Russian Journal of Bioorganic Chemistry

出版年：2015

作者：Dongquan Chen (1)
Todd A Stueckle (2)
Sudjit Luanpitpong (3)
Yon Rojanasakul (3)
Yongju Lu (4)
Liying Wang (2)

1. Division of Preventive Medicine ; Department of Medicine ; University of Alabama at Birmingham ; Birmingham ; AL ; 35294 ; USA
2. Pathology and Physiology Research Branch ; National Institute for Occupational Safety and Health ; Morgantown ; WV ; 26505 ; USA
3. Department of Pharmaceutical Sciences and Mary Babb Randolph Cancer Center ; West Virginia University ; Morgantown ; WV ; 26506 ; USA
4. Department of Pharmaceutical Sciences ; Wayne State University ; Detroit ; MI ; 48201 ; USA

关键词：Single ; walled carbon nanotubes ; Lung ; Microarray ; Gene expression ; Pathways ; p53

刊名：Nanoscale Research Letters

出版年：2015

作者：Francesca Cerreta (1) (4)
R. Temple (2)
Y. Asahina (3)
C. Connaire (1)

1. Human Medicines Research & Development Support Division ; Scientific Advice ; European Medicines Agency ; London ; UK
4. Human Medicines Research & Development Support Division ; Scientific Advice ; London ; UK
2. Center for Drug Evaluation and Research ; US Food and Drug Administration ; London ; UK
3. Office of New Drug II ; Pharmaceuticals and Medical Devices Agency ; London ; UK

关键词：Older population ; clinical development ; regulators ; pharmacokinetics ; ICH E7

刊名：The journal of nutrition, health & aging

出版年：2015

作者：S. Lowes (1)
R. Hucker (2)
M. Jemal (3)
J. C. Marini (4)
V. M. Rezende (5)
R. Shoup (6)
P. Singhal (7)
P. Timmerman (8)
T. Yoneyama (9)
N. Weng (10)
D. Zimmer (11)

1. Bioanalytical and ADME Labs ; Quintiles ; 19 Brown Road ; Ithaca ; New York ; 14850 ; USA
2. A4P Consulting Ltd. ; Discovery Park ; Sandwich ; Kent ; CT13 9ND ; UK
3. 931 Edinburg Road ; Hamilton Square ; New Jersey ; 08690 ; USA
4. Biologics Clinical Pharmacology ; Janssen Research and Development ; LLC ; 1400 McKean Road ; Spring House ; Pennsylvania ; 19477 ; USA
5. Department of Hematology ; School of Medicine ; University of S茫o Paulo ; S茫o Paulo ; Brazil
6. AIT Bioscience ; LLC ; 7840 Innovation Blvd ; Indianapolis ; Indiana ; 46278 ; USA
7. Alkem Laboratories Ltd ; C-17/7 ; MIDC Industrial Estate ; Taloja ; Navi Mumbai ; Mumbai ; 410208 ; India
8. Janssen Research & Development ; Turnhoutseweg 30 ; 2340 ; Beerse ; Belgium
9. Drug Metabolism and Pharmacokinetics Research Laboratories ; Pharmaceutical Research Division ; Takeda Pharmaceutical Company Limited ; 26-1 ; Muraoka-Higashi 2-Chome ; Fujisawa ; Kanagawa ; 251-8555 ; Japan
10. Pharmacokinetics ; Dynamics & Metabolism ; Janssen Research and Development ; 1400 McKean Road ; Spring House ; Pennsylvania ; 19477 ; USA
11. Zimmer BioAnalytics & More ; St. Alban-Ring 282 ; CH-4052 ; Basel ; Switzerland

关键词：bioanalysis ; chromatographic ; regulated ; tiered approaches

刊名：The AAPS Journal

出版年：2015