作者： Esther K. Schmitt ; D. Hoepfner ; P. Krastel

关键词：Natural products ; Target identification ; Chemical proteomics ; Genetic screens ; Cancer ; Antibiotic ; Malaria

刊名：Journal of Industrial Microbiology and Biotechnology

出版年：2016

作者：Matthew N. Meriggioli (1)
Ronenn Roubenoff (1)

1. Department of Musculoskeletal Translational Medicine ; Novartis Institutes for Biomedical Research ; 220 Massachusetts Avenue ; Cambridge ; MA ; 02139 ; USA

关键词：Sarcopenia ; Cachexia ; Muscular dystrophies ; Muscle wasting ; Atrophy

刊名：Calcified Tissue International

出版年：2015

作者：Weiqing Jing (1)
Jill A Gershan (1)
James Weber (1)
Dominique Tlomak (1)
Laura McOlash (1)
Catherine Sabatos-Peyton (2)
Bryon D Johnson (1)

1. Division of Hematology/Oncology/Transplant ; Department of Pediatrics ; Medical College of Wisconsin ; Milwaukee ; WI ; 53226 ; USA
2. Novartis Institutes for BioMedical Research ; Inc. ; Cambridge ; MA ; 02139 ; USA

关键词：Low dose whole body irradiation ; Immune checkpoint proteins ; Blockade ; PD ; L1 ; TIM3 ; LAG3 ; CTLA4 ; 2B4 ; Myeloma

刊名：Journal for Immunotherapy of Cancer

出版年：2015

作者：Christopher Evans (1)
Mark Arnold (2)
Peter Bryan (3)
Jeffrey Duggan (4)
Christopher A James (5)
Wenkui Li (6)
Steve Lowes (7)
Luca Matassa (8)
Timothy Olah (9)
Philip Timmerman (10)
Xiaomin Wang (11)
Enaksha Wickremsinhe (12)
John Williams (13)
Eric Woolf (14)
Patricia Zane (15)

1. Bioanalytical Science and Toxicokinetics (BST) ; PTS-DMPK ; GlaxoSmithKline ; 709 Swedeland Road ; King of Prussia ; PA ; 19406 ; USA
2. Bioanalytical Sciences and Selective Integration ; Bristol-Myers Squibb ; Princeton ; NJ ; 08543 ; USA
3. B2S Consulting ; Mendham ; NJ ; 07945 ; USA
4. Bioanalysis and Metabolite Profiling ; Boehringer-Ingelheim Pharmaceuticals Inc. ; Ridgefield ; CT ; 06877 ; USA
5. Bioanalytical Sciences ; PKDM ; Amgen ; Thousand Oaks ; CA ; 91320 ; USA
6. DMPK/Early Bioanalytics & Technology (EBT) ; Novartis Institutes for BioMedical Research ; East Hanover ; NJ ; 07936 ; USA
7. Bioanalytical and ADME Labs ; Quintiles ; Ithaca ; NY ; 14850 ; USA
8. Bioanalytical QPS ; LLC ; Newark ; DE ; USA
9. Bioanalytical Research ; Bristol-Myers Squibb ; Princeton ; NJ ; USA
10. Janssen Research & Development ; Beerse ; Belgium ; 2340
11. Bioanalysis ; DMPK ; Celgene Corporation ; Summit ; NJ ; 07901 ; USA
12. Lilly Research Laboratories ; Eli Lilly and Company ; Indianapolis ; IN ; 46285 ; USA
13. Drug Metabolism and Pharmacokinetics ; Vertex Pharmaceuticals Inc. ; Boston ; MA ; 02210 ; USA
14. PPDM Global Bioanalytics ; Merck and Company ; West Point ; PA ; 19486 ; USA
15. Drug Disposition ; Safety ; and Animal Research (DSAR) ; Sanofi U.S. ; Bridgewater ; NJ ; 08807 ; USA

刊名：The AAPS Journal

出版年：2015

作者：Gerd A. Kullak-Ublick (1) (2)
Michael Merz (2)
Louis Griffel (6)
Neil Kaplowitz (3)
Paul B. Watkins (4) (5)

1. Department of Clinical Pharmacology and Toxicology ; University Hospital Zurich ; Raemistrasse 100 ; 8091 ; Zurich ; Switzerland
2. Discovery and Investigative Safety ; Novartis Institutes for BioMedical Research ; Basel ; Switzerland
6. Novartis Pharmaceuticals Corporation ; One Health Plaza ; East Hanover ; NJ ; 07936-1080 ; USA
3. University of Southern California Research Center for Liver Diseases ; Keck School of Medicine ; University of Southern California ; Los Angeles ; USA
4. The Hamner-University of North Carolina Institute for Drug Safety Sciences ; Research Triangle Park ; NC ; USA
5. Schools of Medicine ; Pharmacy and Public Health ; University of North Carolina ; Chapel Hill ; NC ; USA

刊名：Drug Safety

出版年：2014

作者：Michael Merz (1)
Kwan R. Lee (2)
Gerd A. Kullak-Ublick (1) (3)
Andreas Brueckner (4)
Paul B. Watkins (5) (6)

1. Discovery and Investigative Safety ; Novartis Institutes for BioMedical Research ; Klybeckstrasse 141 ; WKL-135.1.78 ; 4057 ; Basel ; Switzerland
2. Medical Analytics ; GlaxoSmithKline ; Collegeville ; PA ; USA
3. Department of Clinical Pharmacology and Toxicology ; University Hospital Zurich ; Zurich ; Switzerland
4. Novartis Pharma AG ; Basel ; Switzerland
5. The Hamner-University of North Carolina Institute for Drug Safety Sciences ; Research Triangle Park ; NC ; USA
6. Schools of Medicine ; Pharmacy and Public Health ; University of North Carolina ; Chapel Hill ; NC ; USA

刊名：Drug Safety

出版年：2014

作者：Mark I. Avigan (1)
Einar S. Bjornsson (2)
Markku Pasanen (3)
Charles Cooper (4)
Raul J. Andrade (5)
Paul B. Watkins (6) (9)
James H. Lewis (7)
Michael Merz (8)

1. Office of Surveillance and Epidemiology ; Center for Drug Evaluation and Research ; Food and Drug Administration ; 10903 New Hampshire Avenue ; Silver Spring ; MD ; 20993 ; USA
2. The National University Hospital of Iceland ; Reykjav铆k ; Iceland
3. Faculty of Health Sciences ; School of Pharmacy Kuopio ; University of Eastern Finland ; Kuopio ; Finland
4. Becton Dickenson ; Franklin Lakes ; NJ ; USA
5. Gastroenterology Service and Liver Unit ; Centro de Investigaci贸n Biom茅dica en Red de Enfermedades Hep谩ticas y Digestivas (CIBERehd) ; Instituto de Investigaci贸n Biom茅dica de M谩laga (IBIMA) ; University Hospital Virgen de la Victoria ; Universidad de M谩laga ; Malaga ; Spain
6. The Hamner-University of North Carolina Institute for Drug Safety Sciences ; 6 Davis Drive ; PO Box 12137 ; Research Triangle Park ; NC ; 27709 ; USA
9. Schools of Medicine ; Pharmacy and Public Health ; University of North Carolina ; Chapel Hill ; NC ; USA
7. Georgetown University ; Washington ; DC ; USA
8. Discovery and Investigative Safety ; Novartis Institutes for BioMedical Research ; Basel ; Switzerland

刊名：Drug Safety

出版年：2014

作者：Paolo Tosco (1)
Nikolaus Stiefl (2)
Gregory Landrum (2)

1. Department of Drug Science and Technology ; University of Turin ; Via Pietro Giuria 9 ; 10125 ; Torino ; Italy
2. Novartis Institutes for Biomedical Research ; Basel ; CH-4002 ; Switzerland

关键词：Molecular mechanics ; Force field ; MMFF ; RDKit

刊名：Journal of Cheminformatics

出版年：2014

作者：Marc Sultan (3) (4)
Vyacheslav Amstislavskiy (3)
Thomas Risch (3)
Moritz Schuette (3)
Simon D枚kel (3)
Meryem Ralser (3)
Daniela Balzereit (3)
Hans Lehrach (3)
Marie-Laure Yaspo (3)

3. Max Planck Institute for Molecular Genetics ; Ihnestr. 63-73 ; Berlin ; 14195 ; Germany
4. Novartis Institutes for Biomedical Research ; Biomarker Development ; Fabrikstr. 10 ; Basel ; Switzerland

关键词：RNA ; Seq ; RNA extraction ; rRNA depletion ; poly(A)+鈥塻election ; Intronic reads

刊名：BMC Genomics

出版年：2014

作者：Bahar Yilmazel (8)
Yanhui Hu (8)
Frederic Sigoillot (9)
Jennifer A Smith (10)
Caroline E Shamu (10)
Norbert Perrimon (11) (8)
Stephanie E Mohr (8)

8. Drosophila RNAi Screening Center ; Department of Genetics ; Harvard Medical School ; 77 Avenue Louis Pasteur ; Boston ; MA ; 02115 ; USA
9. Novartis Institutes for Biomedical Research ; Developmental and Molecular Pathways ; 250 Massachusetts Avenue ; Cambridge ; MA ; 02139 ; USA
10. ICCB-Longwood Screening Facility ; Harvard Medical School ; 250 Longwood Ave ; Boston ; MA ; 02115 ; USA
11. Howard Hughes Medical Institute ; 77 Avenue Louis Pasteur ; Boston ; MA ; 02115 ; USA

关键词：RNAi ; Off ; target effects ; Data analysis ; Seed region ; miRNA ; siRNA ; shRNA ; High ; throughput screening

刊名：BMC Bioinformatics

出版年：2014