作者：Cheryl L. M. Stults (1)
Jaromir Mikl (2)
Oliver Whelehan (3)
Bradley Morrical (4)
William Duffield (1)
Lee M. Nagao (5)

1. Novartis Pharmaceuticals Corp ; San Carlos ; California ; USA
2. Boehringer Ingelheim ; Ridgefield ; Connecticut ; USA
3. GlaxoSmithKline ; Brentford ; Middlesex ; UK
4. Novartis Pharma AG ; Basel ; Switzerland
5. IPAC-RS ; Drinker Biddle & Reath ; LLP ; Washington ; District of Columbia ; 20005 ; USA

关键词：design of experiments ; extractables ; injection molding ; leachables ; process parameters ; quality by design

刊名：AAPS PharmSciTech

出版年：2015

作者：Christian Dittrich (1)
Michael A. Fridrik (2)
Robert Koenigsberg (1)
Chooi Lee (3)
Rainer-Georg Goeldner (4)
James Hilbert (5)
Richard Greil (6)

1. Ludwig Boltzmann Institute for Applied Cancer Research (LBI-ACR VIEnna) 鈥?LB Cluster Translational Oncology and Applied Cancer Research-Institution for Translational Research Vienna (ACR-ITR VIEnna) ; Third Medical Department ; Center for Oncology and Hematology ; Kaiser-Franz-Josef-Spital ; Vienna ; Austria
2. Center for Hematology and Medical Oncology ; General Hospital Linz ; Linz ; Austria
3. Boehringer Ingelheim Ltd. ; Bracknell ; Berkshire ; UK
4. Boehringer Ingelheim Pharma GmbH & Co. KG ; Biberach an der Ri脽 ; Germany
5. Boehringer Ingelheim Pharmaceuticals ; Inc ; Ridgefield ; CT ; USA
6. Third Medical Department of Hematology ; Medical Oncology ; Hemostaseology ; Rheumatology and Infectiology ; Salzburg Cancer Research Institute ; Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR) and Center for Clinical Cancer and Immunology Trials (SCRI-CCCIT) ; Paracelsus Medical University ; Salzburg ; Austria

关键词：Aurora kinase ; Clinical trials ; Phase 1 ; Maximum tolerated dose ; Pharmacodynamics ; Pharmacokinetics ; Solid tumors

刊名：Investigational New Drugs

出版年：2015

作者：Christopher Evans (1)
Mark Arnold (2)
Peter Bryan (3)
Jeffrey Duggan (4)
Christopher A James (5)
Wenkui Li (6)
Steve Lowes (7)
Luca Matassa (8)
Timothy Olah (9)
Philip Timmerman (10)
Xiaomin Wang (11)
Enaksha Wickremsinhe (12)
John Williams (13)
Eric Woolf (14)
Patricia Zane (15)

1. Bioanalytical Science and Toxicokinetics (BST) ; PTS-DMPK ; GlaxoSmithKline ; 709 Swedeland Road ; King of Prussia ; PA ; 19406 ; USA
2. Bioanalytical Sciences and Selective Integration ; Bristol-Myers Squibb ; Princeton ; NJ ; 08543 ; USA
3. B2S Consulting ; Mendham ; NJ ; 07945 ; USA
4. Bioanalysis and Metabolite Profiling ; Boehringer-Ingelheim Pharmaceuticals Inc. ; Ridgefield ; CT ; 06877 ; USA
5. Bioanalytical Sciences ; PKDM ; Amgen ; Thousand Oaks ; CA ; 91320 ; USA
6. DMPK/Early Bioanalytics & Technology (EBT) ; Novartis Institutes for BioMedical Research ; East Hanover ; NJ ; 07936 ; USA
7. Bioanalytical and ADME Labs ; Quintiles ; Ithaca ; NY ; 14850 ; USA
8. Bioanalytical QPS ; LLC ; Newark ; DE ; USA
9. Bioanalytical Research ; Bristol-Myers Squibb ; Princeton ; NJ ; USA
10. Janssen Research & Development ; Beerse ; Belgium ; 2340
11. Bioanalysis ; DMPK ; Celgene Corporation ; Summit ; NJ ; 07901 ; USA
12. Lilly Research Laboratories ; Eli Lilly and Company ; Indianapolis ; IN ; 46285 ; USA
13. Drug Metabolism and Pharmacokinetics ; Vertex Pharmaceuticals Inc. ; Boston ; MA ; 02210 ; USA
14. PPDM Global Bioanalytics ; Merck and Company ; West Point ; PA ; 19486 ; USA
15. Drug Disposition ; Safety ; and Animal Research (DSAR) ; Sanofi U.S. ; Bridgewater ; NJ ; 08807 ; USA

刊名：The AAPS Journal

出版年：2015

作者：Michael P Perring (1)
Rachel J Standish (1)
Richard J Hobbs (1)

关键词：No ; analogue ecosystem ; Biodiversity conservation ; Ecosystem function ; Ecological restoration ; Restoration baseline ; Ridgefield multiple ecosystem services experiment ; York gum woodland

刊名：Ecological Processes

出版年：2013

作者：H. Hosseini (1)
N. Namazi (2) nasirnamazi@gmail.com

刊名：Acta Mechanica

出版年：2012

作者：Stephen D. Bendel (1)
Robert Bona (1)
William L. Baker (1)

关键词：anticoagulation ; atrial fibrillation ; dabigatran ; direct thrombin inhibitor ; stroke

刊名：Advances in Therapy

出版年：2011

作者：Shueh Hao Lim (1)
Hugh Calkins (1)
Sunil K. Sinha (1) (2)

关键词：Atrial fibrillation ; Dabigatran ; Dronedarone ; Vernakalant ; Anticoagulation ; Medical therapy

刊名：Current Cardiology Reports

出版年：2011

作者：Seyyed M. Hasheminejad and Amir K. Miri

关键词：Acoustic radiation ; Eccentric source ; Fluid ; filled cavity ; Permeable formation

刊名：Acta Mechanica Sinica

出版年：2007

作者：Nurdan Paker MD (1)
Demet Tekd?s (1)
Nur Kesiktas MD ; PhD (2)
Derya Soy MD (1)

关键词：hylan G ; F 20 ; knee osteoarthritis ; TENS ; viscosupplementation

刊名：Advances in Therapy

出版年：2006