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在“Elsevier”中，命中：716条，耗时：小于0.01 秒

1.Synthesis and cytotoxic activity of novel 2,6-disubstituted-4-mor-pholinothieno[3,2-d]pyrimidines as potent anti-tumor agents

作者：Wu Fu Zhu ; Xin Zhai ; Sai Li ; Yun Yun Cao ; Ping Gong ; Ya Jing Liu ; ^{lyjpharm@126.com}

关键词：4-Morpholinothieno[3 ; 2-d]pyrimidine ; Synthesis ; Cytotoxic activity

刊名：Chinese Chemical Letters

出版年：2012

2.Synthesis and evaluation of 1-(substituted)-3-prop-2-ynylureas as antiangiogenic agents

作者：Kingkan Sanphanya^a ; Suvara K. Wattanapitayakul^b ; Orawin Prangsaengtong^c ; Michiko Jo^c ; Keiichi Koizumi^c ; Naotoshi Shibahara^c ; Aroonsri Priprem^d ; Valery V. Fokin^e ; Opa Vajragupta^a ; ^{pyovj@mahidol.ac.th}

关键词：1-(Substituted)-3-prop-2-ynylurea ; Cytotoxic agents ; Tyrosine kinase inhibitors ; EGFR kinase inhibitor ; Antiangiogenic agent

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

3.Assessing signaling pathways associated with in vitro resistance to cytotoxic agents in AML

作者：David B. Rosen^a ; James A. Cordeiro^a ; Aileen Cohen^b ; Norman Lacayo^c ; Donna Hogge^d ; Rachael E. Hawtin^a ; Alessandra Cesano^b ; ^{Alessandra.Cesano@Nodality.com}

关键词：Cell signaling ; Acute myeloid leukemia ; Flow cytometry ; Drug resistance ; Single cell network profiling ; Signaling pathways ; Chemoresistance ; Apoptosis ; DNA damage

刊名：Leukemia Research

出版年：2012

4.Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents

作者：Chiao-Ting Yen^a ; ^b ; Kyoko Nakagawa-Goto^a ; Tsong-Long Hwang^c ; Susan L. Morris-Natschke^a ; Kenneth F. Bastow^d ; Yang-Chang Wu^e ; ^f ; ^g ; ^{yachwu@cmu.edu.tw} ; Kuo-Hsiung Lee^a ; ^h ; ^{khlee@unc.edu}

关键词：13 ; 6-Trihydroxy-9H-xanthen-9-one ; Ggambogic acid (GA) ; Prenylxanthones ; Pyranoxanthones ; Cytotoxicity ; Anti-inflammatory activity

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

5.Synthesis and evaluation of ursolic acid derivatives as potent cytotoxic agents

作者：Kai-Kai Bai^a ; Zhou Yu^a ; Fen-Ling Chen^a ; Feng Li^b ; Wei-Yun Li^b ; Yang-Hao Guo^a ; ^c ; ^{yanghaoguo@yahoo.com.cn} ; ^{bkkaicfl@yahoo.cn}

关键词：OYLZEBAYPFZNTP-ZJXDOTQFSA-N ; WEQHWRQPMPDHSG-PGIIARHVSA-N ; SOTWOXYDXFXGSR-BTXIHYSISA-N ; HGLDZVONEAYGCZ-PNXZZNQOSA-N ; ZUJZLGCGZAXISX-UFNOZGALSA-N ; OKZQOUFSPFMLSQ-ZDIFQBRASA-N ; WGNSPXPBSHKSFS-YUYHOPFCSA-N ; IIGJTAAWPIAXNG-VIFYPKKFSA-N ; KWLIXPDANJYNOY-QXQWIYNL

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

6.Endothelial vascular toxicity from chemotherapeutic agents: Preclinical evidence and clinical implications

作者：Aspasia Soultati^a ; ¹ ; Giannis Mountzios^a ; ¹ ; ^{gmountzios@med.uoa.gr} ; Chrysoula Avgerinou^b ; George Papaxoinis^c ; Dimitrios Pectasides^c ; Meletios-Athanassios Dimopoulos^b ; Christos Papadimitriou^b

关键词：Cytotoxics ; Endothelium ; Toxicity ; Vascular endothelial growth factor ; Flow-mediated dilatation ; Nitrate-mediated dilatation ; Platinum compounds ; Antimetabolites ; Vinca alkaloids ; Taxanes

刊名：Cancer Treatment Reviews

出版年：2012

7.Dasatinib synergizes with both cytotoxic and signal transduction inhibitors in heterogeneous breast cancer cell lines - Lessons for design of combination targeted therapy

作者：Brian J. Park ; Zakary L. Whichard ; Seth J. Corey ; ^{s-corey@northwestern.edu}

关键词：Dasatinib ; Combination index ; Rapamycin ; Molecular targeted therapy

刊名：Cancer Letters

出版年：2012

8.Abietane diterpenes induce cytotoxic effects in human pancreatic cancer cell line MIA PaCa-2 through different modes of action

作者：Marcio Fronza^a ; Evelyn Lamy^b ; Stefan Gü ; nther^c ; Berta Heinzmann^d ; Stefan Laufer^e ; Irmgard Merfort^a ; ^{irmgard.merfort@pharmazie.uni-freiburg.de}

关键词：Peltodon longipes ; Abietane diterpenes ; Cytotoxicity ; MIA PaCa-2 ; Topoisomerase ; Molecular modelling ; Cell cycle ; DNA damage ; Apoptosis

刊名：Phytochemistry

出版年：2012

9.Gold(III) complexes with 2-substituted pyridines as experimental anticancer agents: Solution behavior, reactions with model proteins, antiproliferative properties

作者：Laura Maiore^a ; Maria Agostina Cinellu^a ; ^{cinellu@uniss.it} ; Stefania Nobili^b ; Ida Landini^b ; Enrico Mini^b ; Chiara Gabbiani^c ; Luigi Messori^c ; ^{luigi.messori@unifi.it}

关键词：Gold(III) compound ; Anticancer ; ESI MS

刊名：Journal of Inorganic Biochemistry

出版年：2012

10.Synthesis and evaluation of substituted dibenzo[c,e]azepine-5-ones as P-glycoprotein-mediated multidrug resistance reversal agents

作者：Xiaobo Tang^a ; ^b ; ^&dagger ; ; Xiaoke Gu^a ; ^b ; ^&dagger ; ; Zhiguang Ren^c ; ^d ; Yuanfang Ma^d ; Yisheng Lai^a ; ^b ; Hui Peng^c ; ^{p_h2002@hotmail.com} ; Sixun Peng^a ; ^b ; Yihua Zhang^a ; ^b ; ^{zyhtgd@163.com} ; ^{zyhtgd@sohu.com}

关键词：LCYOGAWWGHCOBZ-ZBJJBXQJSA-N

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

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