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在“Elsevier”中，命中：382条，耗时：0.0130255 秒

1.Best practice in the conduct of key nonclinical cardiovascular assessments in drug development: Current recommendations from the Safety Pharmacology Society

作者：D.J. Leishman^a ; ^{derek.leishman@lilly.com} ; T.W. Beck^b ; N. Dybdal^c ; D.J. Gallacher^d ; B.D. Guth^e ; M. Holbrook^f ; B. Roche^g ; R.M. Wallis^f

关键词：Dogs ; Monkeys ; Methods ; Cardiovascular ; QT Prolongation ; Safety Pharmacology

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2012

2.Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG

作者：Malin K.B. Jonsson^a ; ^{m.k.b.jonsson@umcutrecht.nl} ; Marc A. Vos^a ; Gary R. Mirams^b ; Gö ; ran Duker^c ; Peter Sartipy^d ; Teun P. de Boer^a ; ¹ ; Toon A.B. van Veen^a ; ¹

关键词：APD ; action potential duration ; APD50/90 ; action potential duration at 50/90%of repolarization ; BVR ; beat-to-beat variability of repolarization ; EAD ; early afterdepolarization ; hESC-CM ; human embryonic stem cell-derived cardiomyocyte ; hiPSC-CM ; human ind

刊名：Journal of Molecular and Cellular Cardiology

出版年：2012

3.The pharmacology of nomegestrol acetate

作者：Xiangyan Ruan^a ; Harald Seeger^b ; Alfred O. Mueck^b ; ^{Alfred.Mueck@med-uni-tuebingen.de} ; ^{A.O.Mueck@t-online.de}

关键词：Nomegestrol acetate ; Pharmacology ; Estradiol ; Ethinyl estradiol

刊名：Maturitas

出版年：2012

4.The pharmacology of dienogest

作者：Xiangyan Ruan^a ; H. Seeger^b ; A.O. Mueck^b ; ^{Alfred.Mueck@med-uni-tuebingen.de} ; ^{A.O.Mueck@t-online.de} ; ^{endo.meno@med.uni-tuebingen.de}

关键词：Dienogest ; Pharmacology ; Estradiol ; Ethinyl estradiol

刊名：Maturitas

出版年：2012

5.Botany, traditional uses, phytochemistry and pharmacology of Apocynum venetum L. (Luobuma): A review

作者：Wenyan Xie^a ; Xiaoying Zhang^a ; ^{zhang.xy@nwsuaf.edu.cn} ; Tian Wang^a ; Jianjun Hu^b

关键词：Apocynum venetum L. ; Luobuma ; Phytochemistry ; Pharmacology ; Traditional medicine

刊名：Journal of Ethnopharmacology

出版年：2012

6.Guiding principles for the implementation of non-animal safety assessment approaches for cosmetics: Skin sensitisation

作者：Carsten Goebel^a ; Pierre Aeby^b ; Nadè ; ge Ade^c ; Nathalie Alé ; pé ; e^c ; Aynur Aptula^d ; Daisuke Araki^e ; Eric Dufour^c ; Nicola Gilmour^d ; Jalila Hibatallah^f ; Detlef Keller^g ; Petra Kern^h ; Annette Kirstⁱ ; Monique Marrec-Fairley^j ; Gavin Maxwell^d ; Joanna Rowland^k ; Bob Safford^d ; Florian Schellauf^j ; Andreas Schepky^l ; Chris Seaman^m ; Thomas Teichert^l ; Nicolas Tessierⁿ ; Silvia Teissier^o ; Hans Ulrich Weltzien^p ; Petra Winkler^q ; Julia Scheel^g ; ^{julia.scheel@henkel.com}

关键词：ACD ; allergic contact dermatitis ; AEL ; acceptable exposure level ; APC ; antigen presenting cells ; CEL ; consumer exposure level ; CIR ; cosmetic ingredient review ; COLIPA ; the European Cosmetics Association ; DC ; dendritic cells ; DPRA ; direct peptide reactivit

刊名：Regulatory Toxicology and Pharmacology

出版年：2012

7.Evaluation of clinical safety and tolerance of a Lactobacillus reuteri NCIMB 30242 supplement capsule: A randomized control trial

作者：Mitchell L. Jones^a ; ^b ; ¹ ; ^{mitchell.jones@mcgill.ca} ; ^{mitchell@micropharma.net} ; Christopher J. Martoni^b ; ¹ ; ^{christopher@micropharma.net} ; E. Di Pietro^a ; ^b ; ¹ ; ^{erminia.di_pietro@mail.mcgill.ca} ; ^{erminia@micropharma.net} ; Ryan R. Simon^c ; ^{rsimon@cantox.com} ; Satya Prakash^a ; ^{satya.prakash@mcgill.ca} ; ^{satya@micropharma.net}

关键词：AE ; adverse events ; ALT ; alanine transaminase ; APA ; alginate-poly-l-lysine ; AlkP ; alkaline phosphatase ; AST ; Aspartate Aminotransferase ; bpm ; beats per minute ; BSH ; bile salt hydrolase ; BMI ; body mass index ; Ca2+ ; calcium ; Cl&minus ; chloride ; CSV ; clinic

刊名：Regulatory Toxicology and Pharmacology

出版年：2012

8.Validation of an in vitro contractility assay using canine ventricular myocytes

作者：A.R. Harmer ; ^{alex.harmer@astrazeneca.com} ; N. Abi-Gerges ; M.J. Morton ; G.F. Pullen ; J.P. Valentin ; C.E. Pollard

关键词：Safety assessment ; Cardiac contractility ; Inotropy ; Cardiotoxicity ; Cardiomyocyte ; Left ventricular function

刊名：Toxicology and Applied Pharmacology

出版年：2012

9.HER2-targeted liposomal doxorubicin displays enhanced anti-tumorigenic effects without associated cardiotoxicity

作者：Joseph G. Reynolds^a ; ¹ ; Elena Geretti^a ; ¹ ; Bart S. Hendriks^a ; ¹ ; Helen Lee^a ; Shannon C. Leonard^a ; Stephan G. Klinz^a ; Charles O. Noble^a ; Petra B. Lü ; cker^b ; Peter W. Zandstra^b ; Daryl C. Drummond^a ; Kenneth J. Olivier Jr.^a ; Ulrik B. Nielsen^a ; Clet Niyikiza^a ; Samuel V. Agresta^a ; Thomas J. Wickham^a ; ^{twickham@merrimackpharma.com}

关键词：Stem cell-derived cardiomyocytes ; Doxorubicin ; Preclinical safety ; HER2-targeted liposomal doxorubicin ; Cardiotoxicity ; Safety sciences

刊名：Toxicology and Applied Pharmacology

出版年：2012

10.Guidelines and pharmacopoeial standards for pharmaceutical impurities: Overview and critical assessment

作者：David J. Snodin^a ; ^{snodind@xiphora.com} ; Sean D. McCrossen^b

关键词：Impurities ; Toxicology ; Genotoxic ; TTC ; Drug safety ; Risk assessment ; Analysis ; Pharmacopoeia ; ICH ; Guideline ; Qualification

刊名：Regulatory Toxicology and Pharmacology

出版年：2012

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