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在“Elsevier”中，命中：3,440条，耗时：小于0.01 秒

1.Conformational and stereoeletronic investigations of muscarinic agonists of acetylcholine by NMR and theoretical calculations

作者：Julio Cesar A. da Silva ; Lucas C. Ducati ; Roberto Rittner ; ^{rittner@iqm.unicamp.br}

关键词：Acetylcholine (ACh+) ; Muscarinic acetylcholine receptor (mAChR) ; Muscarinic agonists ; Conformational analysis ; Theoretical calculations ; NMR data

刊名：Journal of Molecular Structure

出版年：2012

2.Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists

作者：Agostino Cilibrizzi^a ; Igor A. Schepetkin^b ; Gianluca Bartolucci^a ; Letizia Crocetti^a ; Vittorio Dal Piaz^a ; Maria Paola Giovannoni^a ; ^{mariapaola.giovannoni@unifi.it} ; Alessia Graziano^a ; Liliya N. Kirpotina^b ; Mark T. Quinn^b ; Claudia Vergelli^a

关键词：Formyl peptide receptors ; Inflammation ; Neutrophils ; Enantiomers ; Pyridazin-3(2H)-ones ; Chiral agonists

刊名：Bioorganic and Medicinal Chemistry

出版年：2012

3.Discovery of thiadiazole amides as potent, S1P₃-sparing agonists of sphingosine-1-phosphate 1 (S1P₁) receptor

作者：Heng Xu ; Haibo Zhang ; Linbo Luan ; Yan Xu ; Chengyong Li ; Yonghui Wang ; Fangbin Han ; Ting Yang ; Feng Ren ; Jia-Ning Xiang ; John D. Elliott ; Yonggang Zhao ; Taylor B. Guo ; Hongtao Lu ; Wei Zhang ; David Hirst ; Matthew Lindon ; Xichen Lin ; ^{Xichen.2.Lin@gsk.com}

关键词：S1P1 receptor agonists ; Thiadiazole amides ; SAR ; Multiple sclerosis (MS)

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

4.Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition

作者：John Skidmore^a ; ^{js930@cam.ac.uk} ; Zeenat Atcha^b ; Emmanuelle Boucherat^a ; Laura Castelletti^c ; Deborah W. Chen^b ; Frank T. Coppo^d ; Leanne Cutler^a ; ^&dagger ; ; Rachel M. Dunsdon^a ; Bronagh M. Heath^e ; Rio Hutchings^a ; David N. Hurst^a ; Sahar Javed^a ; Samuel Martin^a ; Emma S.L. Maskell^f ; David Norton^a ; Darrel J. Pemberton^b ; ^&Dagger ; ; Sally Redshaw^a ; ^§ ; ; Richard Rutter^b ; Sanjeet S. Sehmi^a ; Tiziana Scoccitti^a ; Hannah E. Temple^a ; Pam Theobald^a ; Robert W. Ward^a ; David M. Wilson^a ; ^&dagger ;

关键词：伪7 Nicotinic acetylcholine receptor agonists ; Alzheimer&rsquo ; s disease ; Oxadiazole ; Cognition

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

5.Efficacy and safety of dopamine agonists in restless legs syndrome

作者：Magdolna Hornyak^a ; ^{magdolna.hornyak@uniklinik-freiburg.de} ; Claudia Trenkwalder^b ; ^c ; Ralf Kohnen^d ; ^e ; Hanna Scholz^a

关键词：Restless legs syndrome ; Dopamine agonists ; Treatment efficacy ; Safety ; Quality of life ; Meta-analysis

刊名：Sleep Medicine

出版年：2012

6.Structure-activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR) 纬 Agonists

作者：Kentaro Rikimaru^a ; ^&dagger ; ; Takeshi Wakabayashi^a ; ^&dagger ; ; Hidenori Abe^a ; ^&dagger ; ; Taisuke Tawaraishi^a ; ^&dagger ; ; Hiroshi Imoto^a ; ^&dagger ; ; Jinichi Yonemori^a ; ^&dagger ; ; Hideki Hirose^a ; ^&dagger ; ; Katsuhito Murase^b ; Takanori Matsuo^a ; ^&Dagger ; ; Mitsuharu Matsumoto^a ; ^&Dagger ; ; Chisako Nomura^a ; ^&Dagger ; ; Hiroko Tsuge^a ; ^&Dagger ; ; Naoto Arimura^a ; ^&Dagger ; ; Kazutoshi Kawakami^a ; ^§ ; ; Junichi Sakamoto^a ; ^§ ; ; Miyuki Funami^a ; ^§ ; ; Clifford D. Mol^c ; Gyorgy P. Snell^c ; Kenneth A. Bragstad^c ; Bi-Ching Sang^c ; Douglas R. Dougan^c ; Toshimasa Tanaka^a ; ^§ ; ; Nozomi Katayama^a ; ^&Dagger ; ; Yoshiaki Horiguchi^a ; ^&dagger ; ; ^鈥?/sup> ; Yu Momose^a ; ^¶ ;

关键词：PPAR纬 agonists ; Diabetes mellitus ; SBDD ; Acylsulfonamide ; Isosteric replacement

刊名：Bioorganic and Medicinal Chemistry

出版年：2012

7.Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erb伪

作者：Youseung Shin ; Romain Noel ; Subhashis Banerjee ; Douglas Kojetin ; Xinyi Song ; Yuanjun He ; Li Lin ; Michael D. Cameron ; Thomas P. Burris ; Theodore M. Kamenecka ; ^{kameneck@scripps.edu}

关键词：Nuclear hormone receptor ; Agonists ; Drug discovery ; Medicinal chemistry ; SAR

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

8.Synthesis and evaluation of 2-amido-3-carboxamide thiophene CB₂ receptor agonists for pain management

作者：Derek W. Nelson ; ^{derek.nelson@abbott.com} ; Jennifer M. Frost ; Karin R. Tietje ; Alan S. Florjancic ; Keith Ryther ; William A. Carroll ; Michael J. Dart ; Anthony V. Daza ; Bradley A. Hooker ; George K. Grayson ; Yihong Fan ; Tiffany R. Garrison ; Odile F. El-Kouhen ; Betty Yao ; Madhavi Pai ; Prasant Chandran ; Chang Zhu ; Gin C. Hsieh ; Michael D. Meyer

关键词：CB2 agonists ; Pain management

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

9.Effects of imidazoline I₂ receptor agonists and morphine on schedule-controlled responding in rats

作者：Xiao-Fei An^a ; ^b ; Yanan Zhang^c ; Jerrold C. Winter^a ; Jun-Xu Li^a ; ^{junxuli@buffalo.edu}

关键词：Morphine ; Imidazoline I2 receptor ; Schedule-controlled responding ; Rats ; Dose addition analysis

刊名：Pharmacology Biochemistry and Behavior

出版年：2012

10.Thieno[3,2-b]thiophene-2-carboxylic acid derivatives as GPR35 agonists

作者：Huayun Deng ; Jieyu Hu ; Haibei Hu ; Mingqian He ; Ye Fang ; ^{fangy2@corning.com}

关键词：GPR35 ; Thieno[3 ; 2-b]thiophene-2-carboxylic acid ; Agonists

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

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