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Elsevier电子期刊(21)

在“Elsevier电子期刊”中，命中：21条，耗时：0.1689217 秒

在所有数据库中总计命中：21条

1.The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress

关键词：APD ; action potential duration ; AERS ; adverse event reporting system ; CiPA ; Comprehensive in Vitro Proarrhythmia Assay ; EAD ; early after depolarizations ; ECG ; electrocardiogram ; HESI ; Health and Environmental Sciences Institute ; HT ; high throughput ; hSC-CM ; human cardiac stem cell derived cardiomyocyte ; hERG or IKr ; human ether-à ; -go-go related gene ; ISWG ; In Silico Working Group ; ICWG ; Ion Channel Working Group ; ICH ; International Conference on Harmonisation ; JiCSA ; Japan iPS Cardiac Safe

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

2.Evolving regulatory paradigm for proarrhythmic risk assessment for new drugs

作者：Jose Vicente ; PhD^a ; ^{pepoviru@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; ^{jose.vicente@fda.hhs.gov" class="auth_mail" title="E-mail the corresponding author} ; Norman Stockbridge ; MD ; PhD^b ; David G. Strauss ; MD ; PhD^a

关键词：QTc prolongation ; J&ndash ; Tpeakc ; T-wave morphology ; Torsade de pointes ; hERG block ; Multi-ion channel block

刊名：Journal of Electrocardiology

出版年：2016

3.Personalized in vitro cancer models to predict therapeutic response: Challenges and a framework for improvement

作者：Molly M. Morgan^a ; ¹ ; Brian P. Johnson^a ; ¹ ; Megan K. Livingston^a ; Linda A. Schuler^b ; Elaine T. Alarid^c ; Kyung E. Sung^a ; ^{Kyung.Sung@fda.hhs.gov" class="auth_mail" title="E-mail the corresponding author} ; David J. Beebe^a ; ^c ; ^{djbeebe@wisc.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：AOP ; adverse outcome pathway ; ATP ; adenosine triphosphate ; CAF ; carcinoma associated fibroblast ; CSRA ; chemotherapy sensitivity and resistance assay ; CYP ; cytochrome P450 ; ECM ; extracellular matrix ; ER ; estrogen receptor ; ERE ; estrogen response element ; MTT ; 3-(4 ; 5-dimethylthiazolyl-2)-2 ; 5-diphenyltetrazolium bromide ; 2D ; two dimensional ; 3D ; three dimensional ; OECD ; Occupational Economic Cooperation Development ; TOP ; therapeutic outcome pathway

刊名：Pharmacology and Therapeutics

出版年：2016

4.Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?

作者：Ross H. Johnstone^a ; Eugene T.Y. Chang^b ; Ré ; mi Bardenet^c ; Teun P. de Boer^d ; David J. Gavaghan^a ; Pras Pathmanathan^e ; ¹ ; ^{pras.pathmanathan@fda.hhs.gov" class="auth_mail" title="E-mail the corresponding author} ; Richard H. Clayton^b ; ¹ ; ^{r.h.clayton@sheffield.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Gary R. Mirams^a ; ¹ ; ^{gary.mirams@cs.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：AP[D] ; Action Potential [Duration] ; CMA&ndash ; ES ; Covariance Matrix Adaptation&ndash ; Evolution Strategy ; GP ; Gaussian Process ; MCMC ; Markov Chain Monte Carlo ; NLME ; Non-Linear Mixed Effects ; TP06 ; the ten Tusscher et al. (2006) [45] action potential model ; UQ ; Uncertainty Quantification ; Vm ; trans-membrane Voltage ; VVUQ ; Verification ; Validation & Uncertainty Quantification

刊名：Journal of Molecular and Cellular Cardiology

出版年：2016

5.Identification of compounds that modulate retinol signaling using a cell-based qHTS assay

作者：Yanling Chen^a ; ^{yanling.chen@fda.hhs.gov" class="auth_mail" title="E-mail the corresponding author} ; Srilatha Sakamuru^b ; Ruili Huang^b ; David H. Reese^a ; Menghang Xia^b

关键词：Retinol signaling ; Developmental toxicant ; High-throughput screening ; Stem cell ; LOPAC ; Tox21

刊名：Toxicology in Vitro

出版年：2016

6.Challenges in evaluating cancer as a clinical outcome in postapproval studies of drug safety

作者：Simone P. Pinheiro ; ScD ; MSc^a ; ^{simone.pinheiro@fda.hhs.gov" class="auth_mail" title="E-mail the corresponding author} ; Donna R. Rivera ; PharmD ; MSc^b ; David J. Graham ; MD ; MPH^a ; Andrew N. Freedman ; PhD^b ; Jacqueline M. Major ; PhD ; MS^a ; Lynne Penberthy ; MD ; PhD^b ; Mark Levenson ; PhD^c ; Marie C. Bradley ; PhD ; MPH ; MPharm^a ; ^b ; Hui-Lee Wong ; PhD ; MSc^a ; Rita Ouellet-Hellstrom ; PhD ; MPH^a

关键词：Cancer epidemiology ; Pharmacoepidemiology ; Drug safety

刊名：Annals of Epidemiology

出版年：2016

7.The relationship between parental mental illness and/or substance use disorder on adolescent substance use disorder: Results from a nationally representative survey

作者：Mir M. Ali ; ^{mir.ali@samhsa.hhs.gov" class="auth_mail" title="E-mail the corresponding author} ; David Dean Jr. ; Sarra L. Hedden

关键词：Adolescent ; Substance-related disorders ; Mental health ; Comorbidity

刊名：Addictive Behaviors

出版年：2016

8.Diversity of Clostridium perfringens isolates from various sources and prevalence of conjugative plasmids

作者：Miseon Park^a ; Joanna Deck^a ; Steven L. Foley^a ; Rajesh Nayak^a ; J. Glenn Songer^b ; Janice R. Seibel^c ; Saeed A. Khan^a ; Alejandro P. Rooney^d ; David W. Hecht^e ; Fatemeh Rafii^a ; ^{fatemeh.rafii@fda.hhs.gov" class="auth_mail" title="E-mail the corresponding author}

关键词：Clostridium perfringens ; Plasmid ; Epidemiology ; Diversity ; PFGE

刊名：Anaerobe

出版年：2016

9.A biokinetic model for nickel released from cardiovascular devices

作者：David M. Saylor^a ; ^{david.saylor@fda.hhs.gov" class="auth_mail" title="E-mail the corresponding author} ; Lingga Adidharma^a ; Jeffrey W. Fisher^b ; Ronald P. Brown^a

关键词：Nitinol ; Nickel release ; Diffusion ; Compartment model ; Biomonitoring

刊名：Regulatory Toxicology and Pharmacology

出版年：2016

10.Simple NMR methods for evaluating higher order structures of monoclonal antibody therapeutics with quinary structure

作者：Kang Chen^a ; ^{kang.chen@fda.hhs.gov" class="auth_mail" title="E-mail the corresponding author} ; Dianna S. Long^b ; Scott C. Lute^c ; Michaella J. Levy^b ; Kurt A. Brorson^c ; David A. Keire^b

关键词：Dilution-injection ; SEC-FPLC ; in-situ ; Digestion ; PCA

刊名：Journal of Pharmaceutical and Biomedical Analysis

出版年：2016

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2016年(15)

2015年(6)

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