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在“Elsevier电子期刊”中，命中：205条，耗时：0.1309392 秒

在所有数据库中总计命中：306条

1.3D engineered In vitro hepatospheroids for studying drug toxicity and metabolism

作者：Swati Chitrangi^a ; Prabha Nair^b ; Aparna Khanna^a ; ^{aparna.khanna@nmims.edu}

关键词：3D ; Three-dimensional ; 2D ; Two-dimensional ; CYP ; cytochrome P450 ; GEVAC ; Gelatin-Vinyl Acetate ; MSCs ; Mesenchymal stem cells ; hUC-MSCs ; human umbilical cord derived-mesenchymal stem cells ; HLCs ; Hepatocyte-like cells ; DMEM-LG ; Dulbecco's Modified Eagle's-low glucose ; FBS ; Fetal Bovine Serum ; CD ; Cluster of Differentiation ; AST ; aspartate aminotransferase ; ALT ; alanine aminotransferase ; HR-LC/MS ; high resolution-liquid chromatography mass spectrometry ; m/z ; mass-to-charge ratio ; 7-AAD ; 7-amino ac

刊名：Toxicology in Vitro

出版年：2017

2.Engineered Liver Platforms for Different Phases of Drug Development

作者：Brenton R. Ware¹ ; ² ; Salman R. Khetani² ; ^{skhetani@uic.edu}

关键词：liver-on-a-chip ; microfabrication ; micropatterned co-cultures ; drug-induced liver injury ; primary human hepatocytes

刊名：Trends in Biotechnology

出版年：2017

3.JAK family members: Molecular cloning, expression profiles and their roles in leptin influencing lipid metabolism in Synechogobius hasta

作者：Kun Wu^a ; Xiao-Ying Tan^a ; ^b ; ^{txy7933@163.com} ; ^{txy7933@mail.hzau.edu.cn} ; Yi-Huan Xu^a ; Xi Shi^a ; Yao-Fang Fan^a ; Dan-Dan Li^a ; Xu Liu^c

关键词：ACC ; acetyl-CoA carboxylase ; ATGL ; adipose triglyceride lipase ; FAS ; fatty acid synthase ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; HPRT ; hypoxanthine-guanine phosphoribosyl transferase ; HSL ; hormone-sensitive lipase ; JAK ; janus kinase ; LepR ; leptin receptor ; ME ; malic enzyme ; MS-222 ; tricaine methanesulfonate ; RPL7 ; ribosomal protein L7 ; STAT ; signal transducer and activator of transcription ; TBP ; TATA-box-binding protein ; TG ; triglyceride ; TUBA ; tubulin alpha chain ; UBCE ; ubiquitin-conj

刊名：Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology

出版年：2017

4.Addition of Dexamethasone Alters the Bile Acid Composition by Inducing CYP8B1 in Primary Cultures of Human Hepatocytes

作者：Lisa-Mari Mö ; rk^* ; ^{lisa-mari.mork@ki.se" class="auth_mail" title="E-mail the corresponding author} ; Stephen C. Strom^&dagger ; ; Agneta Mode^&Dagger ; ; Ewa C.S. Ellis^*

关键词：BSEP ; bile salt export pump ; CA ; cholic acid ; CDCA ; chenodeoxycholic acid ; CYP7A1 ; cholesterol 7α-hydroxylase ; CYP8B1 ; sterol 12α-hydroxylase ; CYP27A1 ; sterol 27α-hydroxylase ; FXR ; farnesoid X receptor ; G6Pase ; glucose-6-phosphatase ; GR ; glucocorticoid receptor ; NTCP ; Na+-taurocholate cotransporting polypeptide ; PXR ; pregnane X receptor ; ROR ; retinoid-related orphan receptor

刊名：Journal of Clinical and Experimental Hepatology

出版年：2016

5.Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer

作者：Shalenie P. den Braver-Sewradj^a ; Michiel W. den Braver^a ; Nico P.E. Vermeulen^a ; Jan N.M. Commandeur^a ; Lysiane Richert^b ; ^c ; J. Chris Vos^a ; ^{j.c.vos@vu.nl" class="auth_mail" title="E-mail the corresponding author}

关键词：4&prime ; -OH DF ; 4&prime ; -hydroxy diclofenac ; 5-OH DF ; 5-hydroxy diclofenac ; 7-HC ; 7-hydroxycoumarin ; APAP ; acetaminophen ; CYP ; cytochrome P450 ; DMEM ; Dulbecco's modified Eagle's medium ; DF ; diclofenac ; OH-TC ; hydroxy tolcapone ; TC ; tolcapone ; GST ; glutathione-S-transferase ; PBS ; phosphate-buffered saline ; SULT ; sulfotransferase ; UGT ; UDP glucuronosyltransferase

刊名：Toxicology in Vitro

出版年：2016

6.Metabolic transformations of dietary polyphenols: comparison between in vitro colonic and hepatic models and in vivo urinary metabolites

作者：Claudia Vetrani^a ; ^{c.vetrani@libero.it" class="auth_mail" title="E-mail the corresponding author} ; Angela A. Rivellese^a ; Giovanni Annuzzi^a ; Martin Adiels^b ; ^c ; Jan Boré ; n^b ; Ismo Mattila^d ; Matej Ore&scaron ; ič^d ; Anna-Marja Aura^e

关键词：Polyphenols ; Metabolism ; Phenolic carbon backbone ; In vitro colon model ; Primary hepatocytes

刊名：Journal of Nutritional Biochemistry

出版年：2016

7.Genomics of human fatty liver disease reveal mechanistically linked lipid droplet-associated gene regulations in bland steatosis and nonalcoholic steatohepatitis

作者：Nishika Sahini ; Jü ; rgen Borlak ; ^{Borlak.Juergen@mh-hannover.de" class="auth_mail" title="E-mail the corresponding author}

关键词：ACACB ; acetyl-CoA carboxylase beta acetyl-CoA carboxylase beta ; ACAT1 ; acetyl-CoA acetyltransferase 1 ; ACLY ; ATP citrate lyase ; AMPK ; 5&prime ; AMP-activated protein kinase ; ASCL1 ; acyl-CoA synthetase long-chain family member 1 ; ACSL4 ; acyl CoA synthetases long chain family4 ; AGPAT9 ; acylglycerol-3-phosphate O-acyltransferase 9 ; ANGPTL4 ; angiopoietin-like 4 ; ANXA2 ; annexin A2 ; APOB ; apolipoprotein B ; AQP4 ; aquaporin 4 ; ARG2 ; arginase 2 ; BCL6 ; B-Cell CLL/lymphoma 6 ; β2AR ; β2 adregenic receptor ; CAV

刊名：Translational Research

出版年：2016

8.Nevirapine modulation of paraoxonase-1 in the liver: An in vitro three-model approach

关键词：2D ; two-dimensional ; 3D ; three-dimensional ; 5-HETEL ; 5-hydroxy-eicosatetraenoic acid lactone ; AHLs ; acylhomoserine lactones ; AhR ; arylhydrocarbon receptor ; ANOVA ; analysis of variance ; AREase ; arylesterase activity ; BSA ; bovine serum albumin ; CYP ; cytochrome P450 ; DMSO ; dimethyl sulfoxide ; EROD ; ethoxyresorufin-O-deethylation ; FBS ; foetal bovine serum ; Hcy ; homocysteine ; HcyTL ; homocysteine-thiolactone ; HEPES ; 4-(2-hydroxyethyl)piperazine-1-ethanesulfonic acid ; HIV ; human immunodeficiency virus

刊名：European Journal of Pharmaceutical Sciences

出版年：2016

9.Characterization of release profile of ornithine carbamoyltransferase from primary rat hepatocytes treated with hepatotoxic drugs: Implications for its unique potential as a drug-induced liver injury biomarker

作者：Tomomi Furihata ; ^{tomomif@faculty.chiba-u.jp" class="auth_mail" title="E-mail the corresponding author} ; Takayuki Aizawa ; Akira Koibuchi ; Meiyan Zhu ; Yuki Yamasaki ; Minaka Shibuya ; Kan Chiba

关键词：Ornithine carbamoyltransferase ; Drug-induced liver injury ; Biomarker ; Hepatocytes ; Mitochondria ; Drug development ; Toxicity ; Liver

刊名：Drug Metabolism and Pharmacokinetics

出版年：2016

10.Hepatic B cell leukemia-3 promotes hepatic steatosis and inflammation through insulin-sensitive metabolic transcription factors

作者：Nadine Gehrke¹ ; ^&dagger ; ; Marcus A. Wö ; rns¹ ; ^&dagger ; ; Yvonne Huber¹ ; Moritz Hess² ; Beate K. Straub³ ; Nadine Hö ; velmeyer⁴ ; Ari Waisman⁴ ; Yong Ook Kim⁵ ; Detlef Schuppan⁵ ; Peter R. Galle¹ ; Jö ; rn M. Schattenberg¹ ; ^{joern.schattenberg@unimedizin-mainz.de" class="auth_mail" title="E-mail the corresponding author}

关键词：NAFLD ; non-alcoholic fatty liver disease ; NF-κB ; nuclear factor-kappa B ; Bcl-3 ; B cell leukemia-3 ; NASH ; non-alcoholic steatohepatitis ; HCC ; hepatocellular carcinoma ; TNF ; tumor necrosis factor-alpha ; JNK ; c-jun N-terminal protein kinase ; PPARα ; peroxisome proliferator-activated receptor gamma ; PGC-1α ; coactivator 1α ; HFD ; high-fat ; high-carbohydrate diet ; ROS ; reactive oxygen species ; KEGG ; Kyoto Encyclopedia of Genes and Genomes

刊名：Journal of Hepatology

出版年：2016

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