搜索页_+Enzyme-inhibitor+complex

常用资源

电子图书

期刊论文

学位会议

在“Elsevier电子期刊”中，命中：2,101条，耗时：0.1169481 秒

在所有数据库中总计命中：18,773条

1.Gamma irradiation enhanced Tollip-mediated anti-inflammatory action through structural modification of quercetin in lipopolysaccharide-stimulated macrophages

作者：Eui-Baek Byun^a ; ^b ; Beom-Su Jang^a ; ^b ; Hye-Min Kim^a ; ^d ; Mi-So Yang^c ; Nak-Yun Sung^d ; Eui-Hong Byun^d ; ^{ehbyun80@kongju.ac.kr}

关键词：HPLC ; high-performance liquid chromatography ; HRP ; horseradish peroxidase ; LPS ; lipopolysaccharide ; Tollip ; toll-interacting protein ; TLR ; toll-like receptor ; MHC ; major histocompatibility complex ; NF-κB ; nuclear factor-κB ; IκB ; inhibitor of κB ; TNF-α ; tumor necrosis factor-α ; IL ; interleukin ; MAPK ; mitogen-activated protein kinase ; COX ; cyclooxygenase ; iNOS ; nitric oxide synthase ; NO ; nitric oxide ; ELISA ; enzyme-linked immunosorbent assay ; PGE2 ; prostaglandin E2 ; ROS ; reactive oxygen species ; S

刊名：International Immunopharmacology

出版年：2017

2.Peptide screen identifies a new NADPH oxidase inhibitor: impact on cell migration and invasion

作者：Mohamed Mousslim^a ; Alessandra Pagano^a ; ¹ ; Nicolas Andreotti^b ; ¹ ; Franç ; oise Garrouste^a ; Sylvie Thuault^a ; Vincent Peyrot^a ; Fabrice Parat^a ; José ; Luis^a ; Marcel Culcasi^c ; Sophie Thé ; tiot-Laurent^c ; Sylvia Pietri^c ; Jean-Marc Sabatier^b ; Hervé ; Kovacic^a ; ^{herve.kovacic@univ-amu.fr}

关键词：NADPH oxidase ; Nox1 ; Cell migration ; Reactive oxygen species ; EPR spin trapping ; Superoxide

刊名：European Journal of Pharmacology

出版年：2017

3.Identification of potential inhibitor and enzyme-inhibitor complex on trypanothione reductase to control Chagas disease

作者：Mohammad Uzzal Hossain^a ; ^{uzzalbge10044@gmail.com} ; Arafat Rahman Oany^a ; ^{arafatr@outlook.com} ; Shah Adil Ishtiyaq Ahmad^a ; ^{shahadil_07@yahoo.com} ; Md. Anayet Hasan^b ; ^{anayet_johnny@yahoo.com} ; Md. Arif Khan^a ; ^{arifkhanbge35@gmail.com} ; Md Al Ahad Siddikey^a ; ^{green_world20@yahoo.com}

关键词：Chagas disease ; Pharmacoinformatics ; Molecular docking ; Enzyme-inhibitor complex

刊名：Computational Biology and Chemistry

出版年：2016

4.IκB kinase inhibition as a potential treatment of osteoarthritis - results of a clinical proof-of-concept study

作者：K. Grothe^&dagger ; ; ^{Kirsten.Grothe@sanofi.com} ; K. Flechsenhar^&dagger ; ; ^{Klaus.Flechsenhar@sanofi.com} ; T. Paehler^&Dagger ; ; ^{Tobias.Paehler@sanofi.com} ; O. Ritzeler^§ ; ; ^{Olaf.Ritzeler@sanofi.com} ; J. Beninga^‖ ; ^{Jochen.Beninga@sanofi.com} ; J. Saas^&dagger ; ; ^{Joachim.Saas@sanofi.com} ; M. Herrmann^&dagger ; ; ^{Matthias.Herrmann@sanofi.com} ; K. Rudolphi^&dagger ; ; ^{Karl.Rudolphi@sanofi.com}

关键词：IκB kinase inhibitor ; Slow-release formulation ; Intra-articular injection ; Treatment of knee osteoarthritis ; Clinical findings

刊名：Osteoarthritis and Cartilage

出版年：2017

5.Structure-based exploration and exploitation of the S₄ subsite of norovirus 3CL protease in the design of potent and permeable inhibitors

作者：Anushka C. Galasiti Kankanamalage^a ; Yunjeong Kim^b ; Athri D. Rathnayake^a ; Vishnu C. Damalanka^a ; Pathum M. Weerawarna^a ; Sean T. Doyle^a ; Amer F. Alsoudi^a ; D.M. Padmasankha Dissanayake^a ; Gerald H. Lushington^c ; Nurjahan Mehzabeen^d ; Kevin P. Battaile^e ; Scott Lovell^d ; Kyeong-Ok Chang^b ; ^{kchang@vet.ksu.edu} ; William C. Groutas^a ; ^{bill.groutas@wichita.edu}

关键词：Norovirus ; 3CL protease ; S4 subsite ; Optimization

刊名：European Journal of Medicinal Chemistry

出版年：2017

6.Design, synthesis, and evaluation of a novel series of macrocyclic inhibitors of norovirus 3CL protease

作者：Vishnu C. Damalanka^a ; Yunjeong Kim^b ; Anushka C. Galasiti Kankanamalage^a ; Gerald H. Lushington^c ; Nurjahan Mehzabeen^d ; Kevin P. Battaile^e ; Scott Lovell^d ; Kyeong-Ok Chang^b ; ^{kchang@vet.ksu.edu} ; William C. Groutas^a ; ^{bill.groutas@wichita.edu}

关键词：Macrocyclic inhibitors ; Norovirus ; 3CLprotease

刊名：European Journal of Medicinal Chemistry

出版年：2017

7.Quinazolinone derivatives: Synthesis and comparison of inhibitory mechanisms on α-glucosidase

作者：Mankun Wei^a ; Wei-Ming Chai^a ; ^b ; ^{chaiweiming@jxnu.edu.cn} ; Rui Wang^a ; Qin Yang^a ; ^b ; Zhihong Deng^b ; Yiyuan Peng^a ; ^b ; ^{yypeng@jxnu.edu.cn}

关键词：Quinazolinone ; α-Glucosidase ; Fluorescence ; Docking

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

8.Effect of phytotoxic secondary metabolites and semisynthetic compounds from endophytic fungus Xylaria feejeensis strain SM3e-1b on spinach chloroplast photosynthesis

作者：Martha Lydia Mací ; as-Rubalcava^a ; ^{mmacias@iquimica.unam.mx} ; ^{mamaciasr@gmail.com} ; Marbella Claudia Garcí ; a-Mé ; ndez^a ; Beatriz King-Dí ; az^b ; Norma Angé ; lica Mací ; as-Ruvalcaba^c

关键词：Xylaria feejeensis ; Sapium macrocarpum ; Endophytic fungi ; Cyclohexenone derivative ; Quinone derivative ; Coriloxine ; Phytotoxic compounds ; Photosynthetic activities ; Hill reaction inhibitors ; Uncoupler agents

刊名：Journal of Photochemistry and Photobiology B: Biology

出版年：2017

9.Rational design of nitrofuran derivatives: Synthesis and valuation as inhibitors of Trypanosoma cruzi trypanothione reductase

作者：D.G. Arias^a ; ^b ; F.E. Herrera^b ; A.S. Garay^b ; D. Rodrigues^b ; P.S. Forastieri^c ; L.E. Luna^c ; M.D.L.M. Bü ; rgi^b ; C. Prieto^b ; A.A. Iglesias^a ; ^b ; R.M. Cravero^c ; S.A. Guerrero^a ; ^d ; ^{saguerrero@santafe-conicet.gov.ar}

关键词：Trypanosoma cruzi ; Trypanothione ; Nitroheterocycle drugs ; Nifurtimox

刊名：European Journal of Medicinal Chemistry

出版年：2017

10.Using DFT methodology for more reliable predictive models: Design of inhibitors of Golgi α-Mannosidase II

作者：Adela Bobovská ; ^a ; ^b ; ^{chembobo@savba.sk" class="auth_mail" title="E-mail the corresponding author} ; Igor Tvaro&scaron ; ka^a ; ^{chemitsa@savba.sk" class="auth_mail" title="E-mail the corresponding author} ; Juraj Kó ; ňa^a ; ^{chemkona@savba.sk" class="auth_mail" title="E-mail the corresponding author}

关键词：GMII ; Golgi α-mannosidase II ; LMan ; lysosomal α-mannosidase ; QM-DFT ; quantum mechanical density functional theory calculations ; GH ; glycoside hydrolase ; E.C. ; enzyme commission number ; I-E ; inhibitor-enzyme complex ; I-BS ; inhibitor-binding site complex ; I-BSF ; inhibitor-binding site fragment ; ED ; empirical descriptor ; MMD ; molecular mechanics descriptor ; LIE ; linear interaction energy method

刊名：Journal of Molecular Graphics and Modelling

出版年：2016

按检索点细分(2101)

题名(21)

关键词(44)

文摘(1746)

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700