Accompanied with the orogenic belt evolution stage from collision to post-collision and intraplate stage, the coupled basins transform from foreland basin to extensional basin and strike-slip structural basin. The Mesozoic-Cenozoic basin-orogen coupling of Sanjiang region of western Yunnan is a typical example of this conceptual model. Based on strata and outcrops, the authors divide Mesozoic strata of Lanping-Simao basin into 3 second sequences and 11 third sequences. The 3 second sequences corresponded to the evolutional stage of foreland basin, extensional basin and strike-slip structural basin, on behalf of each single prototype of the sedimentary basin filling. The growth of 11 third sequences controlled by several times non-cyclical basin basement activities including repeatedly deflection response to thrust load, episodic faulting activity of basement, and strike-slip structural function.