The bivalved arthropod Isoxys had a cosmopolitan distribution in Cambrian seas. They are reported from the North America, Spain, Siberia, Australia and Southwest China. All material from China occur in a wide area of the Yangtze Platform, including in the Chengjiang and Guanshan faunas from Yunnan Province, the Kaili fauna from Guizhou Province, and the Changyang district from Huibei Province. Isoxys shandongensis Wang and Huang sp.nov. from the Mantou Formation (Zhangxia Stage) near Sikou Village, Liuzhuang Township, Feixian County, Linyi City of Shandong Province, eastern China, is described in this paper.