Diffusion Monte Carlo method, an effective numerical simulation way for many-body system research in quantum mechanics, has strong nonlinear searching capability for getting global optimal solution. This paper introduces diffusion Monte Carlo method from the domain of quantum mechanics to seismic inversion, which results show the feasibility of the method. On that basis, the inversion of real seismic data gets preferable result, which denotes that diffusion Monte Carlo method has successful application in seismic inversion, has some advantages for avoiding being trapped in local minimum and is suitable for nonlinear, multi-maximum geophysical inverse problem.