Activity of aldehyde dehydrogenase in B-cell and plasma cell subsets of monoclonal gammopathy patients and healthy donors

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• 作者：Pavla Všiansk&aacute ; Renata Bezděkov&aacute ; Fedor Kryukov ; Martina Alm&aacute ; ši ; Luděk Pour ; Miroslav Penka ; Roman H&aacute ; jek and Lucie Ří ; hov&aacute
• 刊名：European Journal of Haematology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：98
• 期：1
• 页码：19-25
• 全文大小：370K
• ISSN：1600-0609

文摘

Aldehyde dehydrogenase (ALDH) is highly active in physiological stem cells as well as in tumor-initiating cells of some malignancies including multiple myeloma (MM). Finding higher activity of ALDH in some cell subsets in monoclonal gammopathies (MG) could identify potential source of myeloma-initiating cells (MICs).