Mechanical circulatory support is associated with loss of platelet receptors glycoprotein Ibα and glycoprotein VI

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• 作者：P. Lukito ; A. Wong ; J. Jing ; J. F. Arthur ; S. F. Marasco ; D. A. Murphy ; P. J. Bergin ; J. A. Shaw ; M. Collecutt ; R. K. Andrews ; E. E. Gardiner and A. K. Davis
• 刊名：Journal of Thrombosis and Haemostasis
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：14
• 期：11
• 页码：2253-2260
• 全文大小：259K
• ISSN：1538-7836

文摘

Ventricular assist devices (VADs) and extracorporeal membrane oxygenation (ECMO) are associated with bleeding that is not fully explained by anticoagulant or antiplatelet use. Exposure of platelets to elevated shear in vitro leads to increased shedding.