A meta-analysis of reflux genome-wide association studies in 6750 Northern Europeans from the general population

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• 作者：F. Bonfiglio ; P. G. Hysi ; W. Ek ; V. Karhunen ; N. V. Rivera ; M. Mä ; nnikkö ; H. Nordenstedt ; M. Zucchelli ; F. Bresso ; F. Williams ; H. Tornblom ; P. K. Magnusson ; N. L. Pedersen ; J. Ronkainen ; P. T. Schmidt and M. D'Amato
• 刊名：Neurogastroenterology & Motility
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：29
• 期：2
• 全文大小：1105K
• ISSN：1365-2982

文摘

Gastroesophageal reflux disease (GERD), the regurgitation of gastric acids often accompanied by heartburn, affects up to 20% of the general population. Genetic predisposition is suspected from twin and family studies but gene-hunting efforts have so far been scarce and no conclusive genome-wide study has been reported. We exploited data available from general population samples, and studied self-reported reflux symptoms in relation to genome-wide single nucleotide polymorphism (SNP) genotypes.