Hydroxysafflor yellow A inhibits TGF-β1-induced activation of human fetal lung fibroblasts in vitro

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• 作者：Ruiyan Pan ; Yadan Zhang ; Baoxia Zang ; Li Tan and Ming Jin
• 刊名：Journal of Pharmacy and Pharmacology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：68
• 期：10
• 页码：1320-1330
• 全文大小：1078K
• ISSN：2042-7158

文摘

Hydroxysafflor yellow A (HSYA) is one of the chemical component isolated from Chinese medicine Carthamus tinctorius L. Our preliminary study confirmed that HSYA attenuated bleomycin-induced pulmonary fibrosis in mice. In this study, we evaluated the effect of HSYA on TGF-β1-induced activation of human fetal lung fibroblasts (MRC-5) and explored the underlying mechanisms of its activity.