Cobalt-Catalyzed Reductive Cross-Coupling Between Styryl and Benzyl Halides

详细信息    查看全文

• 作者：Yingxiao Cai ; Andreas D. Benischke ; Prof. Dr. Paul Knochel and Dr. Corinne Gosmini
• 刊名：Chemistry - A European Journal
• 出版年：2017
• 出版时间：January 5, 2017
• 年：2017
• 卷：23
• 期：2
• 页码：250-253
• 全文大小：450K
• ISSN：1521-3765

文摘

A simple and efficient protocol for the direct reductive cross-coupling between alkenyl and benzyl halides using a Co/Mn system has been developed. This reaction proceeds smoothly in the presence of [CoBr₂(PPh₃)₂] as the catalyst, with NaI as an additive in acetonitrile with a broad scope of functionalized alkenyl and benzyl halides. Different functional groups are tolerated on both coupling partners, thus, significantly extending the general scope of transition-metal-catalyzed benzylation of alkenyl halides. Moderate to excellent yields were also obtained. From a mechanistic point of view, a radical chain mechanism was proposed. This reaction is stereospecific and some studies suggest the retention of the double-bond configuration.