An independent validation of a gene expression signature to differentiate malignant melanoma from benign melanocytic nevi

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• 作者：Loren E. Clarke ; Darl D. Flake II ; Klaus Busam ; Clay Cockerell ; Klaus Helm ; Jennifer McNiff ; Jon Reed ; Jaime Tschen ; Jinah Kim ; Raymond Barnhill ; Rosalie Elenitsas ; Victor G. Prieto ; Jonathan Nelson ; Hillary Kimbrell ; Kathryn A. Kolquist ; Krystal L. Brown ; M. Bryan Warf ; Benjamin B. Roa and Richard J. Wenstrup
• 刊名：Cancer
• 出版年：2017
• 出版时间：February 15, 2017
• 年：2017
• 卷：123
• 期：4
• 页码：617-628
• 全文大小：1940K
• ISSN：1097-0142

文摘

Recently, a 23-gene signature was developed to produce a melanoma diagnostic score capable of differentiating malignant and benign melanocytic lesions. The primary objective of this study was to independently assess the ability of the gene signature to differentiate melanoma from benign nevi in clinically relevant lesions.