Efficient programming of human mesenchymal stem cell-derived hepatocytes by epigenetic regulations

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• 作者：Wei-Lun Tsai ; Po-Hung Yeh ; Chia-Yun Tsai ; Chin-Tsung Ting ; Yen-Hui Chiu ; Mi-Hua Tao ; Wan-Chun Li and Shih-Chieh Hung
• 刊名：Journal of Gastroenterology and Hepatology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：32
• 期：1
• 页码：261-269
• 全文大小：799K
• ISSN：1440-1746

文摘

In view of its unique properties of detoxification and involvement of metabolic and biochemical functions, in vitro hepatocyte culture serves as a valuable material for drug screening and mechanistic analysis for pathology of liver diseases. The restriction of rapid de-differentiation and inaccessibility of human hepatocytes from routine clinical procedure, however, limits its use.