Feasibility and applicability of diffusion-weighted and dynamic contrast-enhanced magnetic resonance imaging in routine assessments of children with high-grade gliomas

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• 作者：Fernando Carceller ; Neil P. Jerome ; Keiko Miyazaki ; David J. Collins ; Matthew R. Orton ; James A. d'Arcy ; Toni Wallace ; Lucas Moreno ; Andrew D. J. Pearson ; Stergios Zacharoulis ; Martin O. Leach ; Lynley V. Marshall and Dow-Mu Koh
• 刊名：Pediatric Blood & Cancer
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：64
• 期：2
• 页码：279-283
• 全文大小：299K
• ISSN：1545-5017

文摘

Diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) have been used as imaging biomarkers in adults with high-grade gliomas (HGGs). We incorporated free-breathing DW-MRI and DCE-MRI, at a single time point, in the routine follow-up of five children (median age 9 years, range 8–15) with histologically confirmed HGG within a prospective imaging study. It was feasible to incorporate DW-MRI and DCE-MRI in routine assessments of children with HGG. DW and DCE parameters were repeatable in paediatric HGG. Higher median ADC_100-1000 significantly correlated with longer survival in our sample.